Evolution of rhodium(III) and iridium(III) chelates as metallonucleases

Spectroscopic and electrochemical study for evaluating DNA interaction activity of 4‐(3‐halophenyl)‐6‐(pyridin‐2‐yl)pyrimidin‐2‐amine based piano stool Cp* Rh (III) and Ir (III) complexes

“…The binding strength of metal complexes with DNA are comparable to reported complexes such as [Cu (pyzdc) 2 (H 2 O) 2 ].6H 2 O ( K b = 1.44 x 10 5 M −1 ), [Pd(H‐Msal‐mtsc)Cl (PPh 3 )] ( K b = 1.44 x 10 5 M −1 ), [Pd(H‐Msal‐metsc)Cl (PPh 3 )] ( K b = 1.69 x 10 5 M −1 ) and [(Pd(H‐Msal‐mtsc)) 2 (μ‐ppm)] ( K b = 1.89 x 10 5 M −1 ); while K b values of complexes are higher than reported complexes such as [PdCl (dapdoH)] ( K b = 4.6 x 10 4 M −1 ) and [Pd (Msal‐tsc)(PPh 3 )] ( K b = 5.0 x 10 4 M −1 ) . Similar binding ability is observed for half sandwich Rh and Ir complexes in the literature . So, this study suggests the intercalation mode of binding for DNA‐complex interaction…”

“…In continuation of our earlier work, we synthesized a novel class of three pyridyl pyrimidine based ligands and their total six Rh (III) and Ir (III) metal based η 5 ‐C 5 Me 5 piano stool type of compounds to study their biological significance. The complexes were characterized by various analytical (TGA, C,H,N‐elemental analysis, electrical conductance and magnetic moment measurement) and spectroscopic techniques (FT‐IR, 1 H‐NMR and 13 C (APT) NMR).…”

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

“…In vitro antibacterial activity of free ligands and synthesized palladium(II) complexes was measured against two Gram‐positive bacteria (+ve): Staphylococcus aureus , Bacillus subtilis and three Gram‐negative bacteria (−ve): Serratia marcescens , Escherichia coli , Pseudomonas aeruginosa . The detailed experiment process was as reported in the literature …”

Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

“…Complex 1 showed a greatest effect on viscosity of DNA among all the compounds and higher than of EB, indicating the nature of the central metal is also effective in increasing the length of DNA biopolymer. 60 Thus, all these observations suggest that both complexes can bind to DNA through intercalation. The observed viscosity results were in accordance with absorption titration results.…”