Evolution of circadian rhythms: from bacteria to human

Bhadra, Utpal; Thakkar, Nirav; Das, Paromita; Bhadra, Manika Pal

doi:10.1016/j.sleep.2017.04.008

Cited by 120 publications

(88 citation statements)

References 206 publications

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“…The circadian clock is a biological function that has been particularly preserved throughout species evolution, and it is present in almost all living organisms [3]. In humans, circadian clock is regulated by a central stimulator located in the suprachiasmatic nuclei of the hypothalamus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

et al. 2020

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Background: Circadian clock alterations were poorly reported in trauma patients, although they have a critical role in human physiology. Core body temperature is a clinical variable regulated by the circadian clock. Our objective was to identify the circadian temperature disruption in trauma patients and to determine whether these disruptions were associated with the 28-day mortality rate. Methods: A retrospective and observational single-center cohort study was conducted. All adult severe trauma patients admitted to the intensive care unit of Aix Marseille University, North Hospital, from November 2013 to February 2018, were evaluated. The variations of core body temperature for each patient were analyzed between days 2 and 3 after intensive care unit admission. Core body temperature variations were defined by three parameters: mesor, amplitude, and period. A logistic regression model was used to determine the variables influencing these three parameters. A survival analysis was performed assessing the association between core body temperature rhythm disruption and 28-day mortality rate. A post hoc subgroup analysis focused on the patients with head trauma. Results: Among the 1584 screened patients, 248 were included in this study. The period differed from 24 h in 177 (71%) patients. The mesor value (°C) was associated with body mass index and ketamine use. Amplitude (°C) was associated with ketamine use only. The 28-day mortality rate was 18%. For all trauma patients, age, body mass index, intracranial hypertension, and amplitude were independent risk factors. The patients with a mesor value < 36.9°C (p < 0.001) and an amplitude > 0.6°C (p < 0.001) had a higher 28-day mortality rate. Among the patients with head trauma, mesor and amplitude were identified as independent risk factors (HR = 0.40, 95% CI [0.23-0.70], p = 0.001 and HR = 4.73, 95% CI [1. 38-16.22], p = 0.01). Conclusions:Our results highlight an association between core body temperature circadian alteration and 28-day mortality rate. This association was more pronounced in the head trauma patients than in the non-head trauma patients. Further studies are needed to show a causal link and consider possible interventions.

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Section: Introductionmentioning

confidence: 99%

Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

et al. 2020

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“…The sleep–wake cycle is a circadian rhythm. Circadian rhythms are physiologic or behavioral cycles with a recurring periodicity of approximately 24 hr and can be measured as daily oscillations of hormones (melatonin, cortisol), core body temperature, rest‐activity cycles or transcriptome patterns [Bhadra, Thakkar, Das, & Pal Bhadra, ]. There is good evidence that circadian rhythm sleep–wake disorders (CRSWDs) play a role in many psychiatric illnesses such as depression, posttraumatic stress disorder, and eating disorders, which are often comorbid with ASD [Schuch, Genro, Bastos, Ghisleni, & Tovo‐Rodrigues, ].…”

Section: Introductionmentioning

confidence: 99%

Sleep problems in adults with autism spectrum disorder and intellectual disability

Ballester

Martı́nez

Javaloyes³

et al. 2018

Autism Research

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Sleep problems (SP) are recognized as a common comorbid condition in autism spectrum disorder (ASD) and can influence core autism symptoms and mental and physical health. SPs can be lifelong and have been reported that adults on the autistic spectrum with and without intellectual disability (ID) present SPs (longer sleep latency, frequent night awakenings, and circadian rhythm sleep-wake disorders). A prospective, objective sleep study was conducted in 41 adults with ASD (33 AE 6 years old) and ID and 51 typically developing adults (33 AE 5 years old) using ambulatory circadian monitoring (ACM) recording wrist temperature, motor activity, body position, sleep, and light intensity. The findings indicated that individuals with ASD presented sleep difficulties including low sleep efficiency, prolonged sleep latency and increased number and length of night awakenings, together with daily sedentary behavior, and increased nocturnal activity. Furthermore, indications of an advanced sleepwake phase disorder were found in these autistic adults. Examining sleep and markers of the circadian system showed significant differences between adults with ASD and ID and an age-matched, healthy adult population. The sleep disturbances described for this sample of adults with ASD and ID are similar to those of already described for adults with ASD without ID; their relationship with intellectual ability should be further studied. Improving knowledge of sleep patterns in ASD adults with ID might help to designed targeted interventions to improve their functioning and reduce family stress. Autism Research 2019, 12: 66-79.Lay Summary: SPs are very frequent in autism from childhood to adulthood. We recorded sleep with a watch-like device in adults with autism and ID and compared sleep patterns with nonautistic volunteers. Results showed poorer sleep conditions in adults with autism (increased sleep latency and number/length of night awakenings) that resulted in decreased sleep efficiency. Increasing knowledge of the SPs in adults on the autism spectrum will allow to improve their and their families' quality of life.

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“…In plants, this study showed that LUX co-regulated both cell-cycle progression and cell-fate determination in meristem cells, achieving coupling between cell differentiation and cell division (endoreduplication). These frameworks may be extended to animals that have independently acquired circadian clock systems during evolution 1, 42 . Indeed, cell differentiation mechanism in plants and animals has functionally analogous features.…”

Section: Discussionmentioning

confidence: 99%

Actual time-series of single-cell transcriptomics reveals circadian clocks as key regulators of cell differentiation in Arabidopsis

Torii

Inoue

Bekki

et al. 2020

Preprint

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The basis of toti/pluripotency is elaborate regulation of cell-cycle progression and cell-fate determination. Circadian clocks are involved in this process, but the underlying mechanisms have not been studied due to technical limitations. In particular, there is a lack of research on the universality of cell differentiation mechanisms in multicellular organisms using plants with high cell-fate plasticity. Here, exploiting in vivo single-cell RNA sequencing and a new actual time reconstitution method, PeakMacth, we analyzed actual time-series of cell reprogramming and differentiation processes at single-cell resolution, and found that the circadian clock modulates cell differentiation via BES1-mediated GSK3 signaling, which has a β-catenin-like function in Arabidopsis. In this pathway, the clock gene LUX in meristematic stem cells directly targets the CYCD and RETINOBLASTOMA-RELATED (RBR) genes, which are commonly involved in cell-cycle progression and cell-fate determination in plants and animals. In addition, the rhythmicity of the circadian clock was associated with cell state, and the establishment of the circadian rhythm preceded cell differentiation. Thus, our study not only reveals the involvement of the circadian clock in the differentiation of plant stem cells but also demonstrates functionally analogous features in the regulatory system of cell differentiation across species.

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Evolution of circadian rhythms: from bacteria to human

Cited by 120 publications

References 206 publications

Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

Sleep problems in adults with autism spectrum disorder and intellectual disability

Actual time-series of single-cell transcriptomics reveals circadian clocks as key regulators of cell differentiation in Arabidopsis

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