Evolution of blood parameters during weight loss in experimental obese Beagle dogs

Abstract

The effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free T4 (fT4), total T4 (TT4), plasma alkaline phosphatases (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), potassium and total proteins] or bimonthly [cholesterol, triglycerides, non-esterified fatty acids (NEFA), insulin-like growth factor I (IGF-I), glucose, insulin] in eight obese Beagles dogs fed either a high protein dry diet, DP (crude protein 47.5%, on dry matter basis) or a commercial high fibre diet, HF (crude protein 23.8%, crude fibre 23.3%). The dogs were allotted to two groups according to sex and body weight (BW) and they were respectively fed with the DP or the control HF diet during 12-26 weeks, until they reach their optimal BW. The plasma basal triglycerides and cholesterol concentrations were decreased by the two diets but the difference was only significant for the DP diet. The plasma mean NEFA concentration increased regularly over the period with the HF diet, without significant difference between the two diets. No effect of diet or weight loss was observed on plasma carnitine, urea, creatinine, ALP, AST, ALT, potassium, TT4, FT4, IGF-I, glucose and insulin. Weight loss induced a decrease in fT4 plasma concentration (p < 0.001). The high protein diet allowed a safe weight loss.

Effect of Weight Loss in Obese Dogs on Indicators of Renal Function or Disease

“…Measurement of GFR before and after weight loss might have helped to differentiate between these possibilities. The decrease in serum creatinine concentration is contradictory to previous studies in obese dogs, whereby increased serum creatinine concentration has been documented following weight loss . This decrease could be the result of loss of muscle mass during weight management.…”

Nutritional Weight Loss Therapy with Cooked Bean Powders Regulates Serum Lipids and Biochemical Analytes in Overweight and Obese Dogs

“…While not statistically significant, dogs consuming beans showed the largest change at 2 weeks whereas the decrease in the control group was similar between 2 and 4 weeks. This finding demonstrated that serum cholesterol reduction may be an early biomarker for a metabolic response to bean intake and weight loss wherein previous reports in dogs showed decreased serum cholesterol after 60 days [53], 90 days [50], and after the full amount of time required to reach ideal weight [54,55]. Furthermore, TG, HDL and LDL were reduced in at least one of the bean diet groups, a finding consistent in human studies [32], with the exception of HDL which has been shown to increase in humans after bean consumption [56].…”

“…ALP was significantly reduced in dogs consuming black beans (P=0.01) and had a decreasing trend in the navy bean group (P=0.08). AST levels have not previously been shown to change with weight loss in dogs [55], however was significantly decreased in the control group (P<0.01). Bilirubin, while not elevated in overweight dogs [50], has been shown to be reduced during weight loss with specific diets [53] as was observed in the control group.…”

“…Bilirubin, while not elevated in overweight dogs [50], has been shown to be reduced during weight loss with specific diets [53] as was observed in the control group. Glucose levels were not altered in any of the 3 diet groups and have not previously been shown to change with weight loss in dogs [50,53,55,71], although increased glucose levels in overweight dogs have been reported [50]. No analyte was changed outside of normal ranges.…”

Effect of feeding a weight loss food beyond a caloric restriction period on body composition and resistance to weight gain in dogs

“…9,[47][48][49][50] In obese dogs, decreases in serum triglyceride, cholesterol and leptin concentrations during weight loss are associated with a decrease in insulin resistance. 9,[47][48][49][50] In obese dogs, decreases in serum triglyceride, cholesterol and leptin concentrations during weight loss are associated with a decrease in insulin resistance.…”