Effect of feeding a weight loss food beyond a caloric restriction period on body composition and resistance to weight gain in dogs

Floerchinger, Amanda M.; Jackson, Matthew I.; Jewell, Dennis E.; MacLeay, Jennifer M.; Paetau-Robinson, Inke; Hahn, Kevin A.

doi:10.2460/javma.247.4.375

Cited by 26 publications

(25 citation statements)

References 43 publications

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“…Clinical blood chemistry was performed on a COBAS c501 module (Roche Diagnostics Corporation, Indianapolis, IN, USA). Analysis of plasma metabolomics was performed by Metabolon (Morrisville, NC) as previously described [38,39].…”

Section: Study Design and Measurementsmentioning

confidence: 99%

Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics

Jackson¹,

Jewell²

2020

PLoS ONE

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The purpose of this study was to examine the influence of medium-chain fatty acid-containing triglycerides (MCT), long-chain polyunsaturated fatty acid-containing triglycerides, and their combination on the plasma metabolome of cats (Felis catus), including circulating microbiome-derived postbiotics. After a 14-day lead-in on the control food, cats were randomized to one of four foods (control, with 6.9% MCT, with fish oil [FO; 0.14% eicosapentaenoate, 1.0% docosahexaenoate], or with FO+MCT; n = 16 per group) for 28 days. Analysis of plasma metabolites showed that the addition of FO and MCT led to synergistic effects not seen with either alone across a number of lipid classes, including fatty acids, acylcarnitines, and acylated amines including endocannabinoids. Notably, the FO+MCT group had an increase in ketone body production relative to baseline and beyond that seen with MCT alone. N-acyl taurines, the accumulation of which has been implicated in the onset of type 2 diabetes, were significantly decreased in the FO+MCT group. Significant decreases in the gut microbiome-derived postbiotic classes of indoles/indolic sulfates and phenols/phenolic sulfates were observed only the FO+MCT group. Overall, the combination of MCT and FO led to number of changes in plasma metabolites that were not observed with either oil alone, particularly in postbiotics.

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Section: Study Design and Measurementsmentioning

confidence: 99%

Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics

Jackson¹,

Jewell²

2020

PLoS ONE

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“…When assessed in a colony setting, weight loss protocols for obese dogs are very successful with typical rates of weight loss consistently over 1 % per week, when restricting caloric intake to 50-75 % of maintenance energy requirements (33)(34)(35)(36) . Whilst there are many advantages to performing such studies in a colony, most notably in consistency and control, the results are not necessarily representative of how obese dogs lose weight when supervised by their owners.…”

Section: Rate Of Weight Loss and Energy Intake During Weight Managementmentioning

confidence: 99%

“…the first 2-3 months) (26,29,32,36) . Such work certainly provides useful information on the early stages of a weight loss protocol, such as initial rate and initial energy intake required for weight loss.…”

Section: Likelihood Of Successfully Reaching Target Weightmentioning

confidence: 99%

Outcomes of weight management in obese pet dogs: what can we do better?

German

2016

Proc. Nutr. Soc.

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Obesity is arguably the biggest health and welfare issue affecting pet dogs. Although successful weight loss has health benefits, current strategies are far from ideal. Many obese dogs that start a weight programme fail to lose weight, or subsequently regain the weight they have lost. Given that current weight loss strategies are not perfect, clinicians need to focus carefully on tailoring the programme, perhaps setting a pragmatic target for weight loss, so as to ensure the benefits are maximised. This review will summarise key findings from recent clinical research into pet obesity, and present a framework for improving success, by better tailoring weight management regimens and end points to the individual.

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“…Many of the first weight loss studies were conducted in research colony dogs, and reported universal success with rates of weight loss progressing at 1–2% per week [ 14 – 16 ]. Other studies have demonstrated successful weight loss in pet dogs with naturally-occurring obesity, although weight loss is slower than in the colony studies (mean <1% per week) [ 10 – 12 ], and many dogs fail to reach their target weight [ 11 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Success of a weight loss plan for overweight dogs: The results of an international weight loss study

et al. 2017

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IntroductionObesity is a global concern in dogs with an increasing prevalence, and effective weight loss solutions are required that work in different geographical regions. The main objective was to conduct an international, multi-centre, weight loss trial to determine the efficacy of a dietary weight loss intervention in obese pet dogs.MethodsA 3-month prospective observational cohort study of weight loss in 926 overweight dogs was conducted at 340 veterinary practices in 27 countries. Commercially available dry or wet weight loss diets were used, with the initial energy allocation being 250–335 kJ/kg target body weight0.75/day (60–80 kcal/kg target body weight0.75/day) depending on sex and neuter status. The primary outcome measure was percentage weight loss; the main secondary outcomes were changes in activity, quality of life, and food-seeking behaviour, which were subjectively determined from owner descriptions.ResultsAt baseline, median (range) age was 74 (12 to 193) months and median body condition score was 8 (range 7–9). 896 of the 926 dogs (97%) lost weight, with mean weight loss being 11.4 ±5.84%. Sexually intact dogs lost more weight than neutered dogs (P = 0.001), whilst female dogs lost more weight than male dogs (P = 0.007), with the difference being more pronounced in North and South American dogs (median [Q1, Q3]: female: 11.5% [8.5%, 14.5%]; male: 9.1% [6.3%, 12.1%], P = 0.053) compared with those from Europe (female: 12.3% [8.9%, 14.9%]; male: 10.9% [8.6%, 15.4%]). Finally, subjective scores for activity (P<0.001) and quality of life (P<0.001) increased sequentially, whilst scores for food-seeking behaviour decreased sequentially (P<0.001) during the study.ConclusionThis is the largest international multi-centre weight loss study conducted to date in obese dogs. Most dogs lost a clinically significant amount of weight, although there were notable differences between dogs of different sex, neuter status and in different geographical locations.

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Effect of feeding a weight loss food beyond a caloric restriction period on body composition and resistance to weight gain in dogs

Abstract: Results suggested that feeding overweight dogs the test food caused weight loss and improvements in body condition during the weight-maintenance phase, possibly because the food composition improved energy metabolism.

Cited by 26 publications

References 43 publications

Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics

Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics

Outcomes of weight management in obese pet dogs: what can we do better?

Success of a weight loss plan for overweight dogs: The results of an international weight loss study

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