Evolution in Inbred Strains of Mice Appears Rapid

Fitch, Walter M.; Atchley, William R.

doi:10.1126/science.4001935

Cited by 97 publications

(24 citation statements)

References 31 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar research of mouse inbred strains has been significant for studies of evolution and disease (Fitch and Atchley 1985;Beck et al 2000). The Canzian (1997) study used a simple distance model (Fitch and Margoliash 1967) with percentages of genotype differences.…”

mentioning

confidence: 99%

Phylogenetics of rat inbred strains

et al. 2003

View full text Add to dashboard Cite

mentioning

confidence: 99%

Phylogenetics of rat inbred strains

et al. 2003

View full text Add to dashboard Cite

“…The (33,34). The level of polymorphism between B6 and BR, as measured by published enzyme polymorphisms (33) and by our experience with the SSLP markers, is -23% compared with the 40-54% polymorphism between a randomly chosen pair of inbred strains of mice (35). Although this common genetic background of BR and B6 mice originally presented an obstacle to mapping genes in crosses because of the low level of polymorphism, the SSLP markers (24,36) are distributed throughout the genome at a sufficiently high density to allow coverage of most of the genome for linkage.…”

mentioning

confidence: 99%

Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.

Poole

Drinkwater

1996

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Hormonal and genetic factors strongly influence the susceptibility of inbred mice to hepatocarcinogenesis. Female C57BR/cdJ (BR) 12) were 5.4-and 4.3-fold more sensitive than mice homozygous for B6 alleles at both loci (6.5 ± 5.4).The risk for liver cancer development is sex-dependent in both humans and mice. The incidence of primary hepatocellular carcinoma (HCC) is 2-to 5-fold higher in men than in women (1-4). At present, it is not known whether this sex difference results from differences in the exposure of men and women to risk factors, such as hepatitis B virus (3, 5), aflatoxin B1 (6), alcohol consumption (1), or from hormonal effects on the pathogenesis of liver cancer (4-6). Sensitivity to hepatocarcinogenesis in mice is highly sexually dimorphic. Male mice have a higher incidence of spontaneous liver tumors than females (7, 8) and are more susceptible to hepatocarcinogenesis following perinatal treatment with a variety of carcinogens (9-11). The sexual dimorphism in murine hepatocarcinogenesis results from the contrasting effects of androgens and ovarian hormones on liver tumor induction; androgens promote hepatocarcinogenesis whereas ovarian hormones inhibit the development of liver tumors (11-13). Thus, castration of male mice results in a decreased yield of liver tumors, whereas ovariectomy of females increases liver tumor multiplicity relative to intact animals (12)(13)(14).One exception to this strong, sex-dependent effect on liver tumor induction in mice is the response of the C57BR/cdJ (BR) inbred strain. Whereas BR males are intermediateThe publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. among inbred strains in sensitivity to hepatocarcinogenesis, the mean tumor multiplicity following perinatal carcinogen treatment in BR females is 15-30 times higher than that observed in the females of other inbred strains (10). The unusual susceptibility of the BR female is characterized by its insensitivity to the suppressing effects of ovarian hormones. In most strains, ovariectomized mice are significantly more susceptible than intact females to liver tumor induction (11, 12) but ovariectomized and intact BR females have similar mean tumor multiplicities (14, 15). In contrast, the responsiveness of BR male mice to the promotion of hepatocarcinogenesis by androgens is similar to that observed in other strains (14, 15).There are large differences among inbred strains in the sensitivity of male mice to hepatocarcinogenesis (7, 9, 10). Analysis of segregating crosses between strains that vary widely in their susceptibility provides a means for mapping genes that contribute to the sensitivity to liver tumor induction. Our laboratory and others have been successful in identifying loci that influence the development of liver tumors in the males of sensitive strains, such as C3H/HeJ (C3H) and DBA/2J (D2), using linkage analysis. Dragani and cow...

show abstract

“…If it is true, knowledge of the precise content of the B6 genome is extremely important before use of the strain in research. Inbred mouse strains have been found to be in high rate of divergence (Fitch & Atchley, 1985), however, the mechanism of rapid evolution is still not understood. What appears to have happened is that, the current B6 dispersed in different breeders is not identical to each other in genetic background.…”

Section: Disscussionmentioning

confidence: 99%

Microsatellite Variation Within Three Populations of Inbred C57BL/6J Strain

Niu¹,

Liang²

2009

Zoological Research

View full text Add to dashboard Cite

Abstract:The goal of this study was to investigate the genetic stability of the C57BL/6J (B6) inbred mouse strain maintained in different breeders. Three populations of B6, Pop1 and Pop2 purchased from Beijing and Pop3 purchased from Shanghai, were examined. Fifteen microsatellite loci reported to be polymorphic among inbred strains were amplified using FAM labeled primers and genotyped with ABI Prism 377 automated sequencer. Seven loci were found polymorphic, and all the loci were homozygous in all the three populations. The present study indicates that genetic variation occurs in different B6 populations although they are still inbred in each breeder. The mechanism of genetic variation is not well understood now, but it is very important to know the precise content of the B6 genome before use of this strain in research.

show abstract

Evolution in Inbred Strains of Mice Appears Rapid

Cited by 97 publications

References 31 publications

Phylogenetics of rat inbred strains

Phylogenetics of rat inbred strains

Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.

Microsatellite Variation Within Three Populations of Inbred C57BL/6J Strain

Contact Info

Product

Resources

About