We discuss the close link between intermittent events ('quakes') and extremal noise fluctuations which has been advocated in recent numerical and theoretical work. From the idea that record-breaking noise fluctuations trigger the quakes, an approximate analytical description of non-equilibrium aging as a Poisson process with logarithmic time arguments can be derived. Theoretical predictions for measurable statistical properties of mesoscopic fluctuations are emphasized, and supporting numerical evidence is included from simulations of short-ranged Ising spin-glass models, of the ROM model of vortex dynamics in type II superconductors, and of the Tangled Nature model of biological evolution.