Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

Braverman, Eric R.; Blum, Kenneth; Hussman, Karl L.; Han, David K.; Dushaj, Kristina; Li, Mona; Marín, Gabriela; Badgaiyan, Rajendra D.; Smayda, Richard; Gold, Mark S.

doi:10.1371/journal.pone.0133609

Cited by 9 publications

(5 citation statements)

References 61 publications

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“…Moreover, it was found that there were significant direct correlations between hippocampal volumes and performance on several different neuropsychological tests when patients and healthy subjects were combined. These findings are in agreement with that found for non-African American populations in Braverman et al [41] who used 3T MRI with sophisticated NeuroQuant® software to measure both evoked potentials and memory/cognition in a mixed gender and age group of cognitively impaired patients. The study revealed hippocampal, central and temporal lobe atrophy, with delayed latency of evoked potentials marginally associated with temporal lobe atrophy.…”

Section: Observations and Discussionsupporting

confidence: 92%

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer’s in Aging African-Americans

et al. 2017

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Alzheimer's disease is an irreversible, progressive brain disorder that slowly destroys cognitive skills and the ability to perform the simplest tasks. More than 5 million Americans are afflicted with Alzheimer's; a disorder which ranks third, just behind heart disease and cancer, as a cause of death for older people. With no real cure and in spite of enormous efforts worldwide, the disease remains a mystery in terms of treatment. Importantly, African-Americans are two times as likely as Whites to develop late-onset Alzheimer's disease and less likely to receive timely diagnosis and treatment. Dopamine function is linked to normal cognition and memory and carriers of the DRD2 Taq1A A1 allele have significant loss of D2 receptor density in the brain. Recent research has shown that A1 carriers have worse memory performance during long-term memory (LTM) updating, compared to non-carriers or A2-carriers. A1carriers also show less blood oxygen level-dependent (BOLD) activation in the left caudate nucleus which is important for LTM updating. This latter effect was only seen in older adults, suggesting magnification of genetic effects on brain functioning in the elderly. Moreover, the frequency of the A1 allele is 0.40 in African-Americans, with an approximate prevalence of the DRD2 A1 allele in 50% of an African-American subset of individuals. This is higher than what is found in a non-screened American population (≤ 28%) for reward deficiency syndrome (RDS) behaviors. Based on DRD2 known genetic polymorphisms, we hypothesize that the DRD2 Taq1A A1 allele magnifies the risk of Alzheimer's in aging African-Americans. Research linking this high risk for Alzheimer's in the African-American population, with DRD2/ANKK1-TaqIA polymorphism and neurocognitive deficits related to LTM, could pave the way for novel, targeted pro-dopamine homeostatic treatment.

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Section: Observations and Discussionsupporting

confidence: 92%

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer’s in Aging African-Americans

et al. 2017

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“…26 EEG as a functional aspect, the early correlation changes of cognition had been raised by the previous studies. 9,27,28 For example, alpha and delta powers were found to be manifestations of cognitive decline, including MCI and dementia. Cognitive estimation is an objective way of evaluating cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

“…The temporal lobe atrophy was correlated with delayed P300 in a group of cognitive dysfunction and brain atrophy group. 9 The spectrum-specific analysis and standardized low-resolution brain electromagnetic tomography (sLORETA) connectivity construction could screen the key modules of dementias. EEG-based sLORETA analysis showed that Alpha-1 relative power current density in parietooccipital brain areas, Beta-1 in the frontal lobe, and delta relative power current density were found to be altered in vascular cognitive impairment, no dementia (VCIND) patients.…”

Section: Introductionmentioning

confidence: 99%

Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients

Chen

Sui

et al. 2020

International Journal of Distributed Sensor Networks

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Vascular dementia, secondary to Alzheimer’s dementia, ranks as one of the most frequent dementia types. The process of vascular dementia is divergent with other neurodegenerative dementias and thus reversible at the early cognitive disorder or mild dementia stages. The encephalography and neuroimaging data mining at different stages would bring neuromodulation strategies in practice; 15 mild cognitive impairment patients and 16 mild vascular dementia patients as well as 17 cognitive healthy controls were screened in this study. Cognitive tests such as Mini-Mental State Examination, Montreal cognitive assessment, voxel-based morphometry, electroencephalography, and standardized low-resolution brain electromagnetic tomography connectivity network were conducted. Compared with healthy group, voxel-based morphometry analysis showed a decrease in gray/cerebrospinal fluid ratio ( p < .05) in mild dementia group; the energy power of gamma band decreased ( p < .05) in mild dementia group; and electroencephalography standardized low-resolution brain electromagnetic tomography analysis showed wider frontal and temporal lobe involvement in mild dementia patients ( p < .05). Network topological analysis screened top 10 key Brodmann areas (44R, 7R, 8L, 22L, 47L, 27L, 1L, 1R, 7R, 43L), which could be underlying neuromodulators for dementia patients. Electroencephalography as well as structural magnetic resonance imaging could be used for the evaluation of cognitive disorder patients. The spectrum-specific standardized low-resolution brain electromagnetic tomography analysis and connectivity network analysis could shed light on the neuromodulator targets in the early phase of dementia.

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“…Several studies elucidate the links between memory and cognitive impairments and negative changes observed in P300 latency and amplitude (Ozen et al, 2013). Because of this evidence, the P300 serves as a sensitive marker for cognitive dysfunction that affects neurological, psychiatric, and developmental areas of the human body (Braverman et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of iron deficiency on behavior and cognition in children

Bahgat

Nasr

El-Sayed³

2022

ijhs

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Background: Iron deficiency (ID) is the most common trace element deficiency in childhood. More than 25% of the world’s population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Aim: is to study the effect of iron deficiency on behavior and cognitive function in children using conners parent rating scales and P300 event-related potentials (ERPs). Patients and Methods: This is a cross sectional comparative study included 20 children with iron deficiency, 20 children with iron deficiency anemia,and 20 healthy children who attended the pediatric out patient’s clinic and inpatient department of Al-Zahraa hospital –Alazhar University for Girls we include children with iron deficiency ,Children with chronic medical conditions,Children with co-morbid psychiatric diagnoses ,children with any form of psychiatric, physical, developmental or Intellectual disability, chronic underlying disease (e.g. inborn error of metabolism, genetic, endocrine or liver disease, vision or hearing impairment) or neurologic disorders were excluded from the study.

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Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

Cited by 9 publications

References 61 publications

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer’s in Aging African-Americans

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer’s in Aging African-Americans

Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients

Effect of iron deficiency on behavior and cognition in children

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