2010
DOI: 10.1016/j.parint.2010.05.002
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Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36

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Cited by 63 publications
(119 citation statements)
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“…To date, research in this field has focused on a few protein candidates including merozoite surface protein (MSP)-1 (14), MSP-2 (8), MSP-3 (15)(16)(17)(18), apical membrane Ag 1 (AMA-1) (19), erythrocyte binding Ag 175 (EBA-175) (20), glutamate-rich protein (GLURP) (15,21), and serine repeat Ag 5 (SERA5) (22). These Ags are all merozoite proteins, either located on the merozoite surface or contained within apical invasion organelles.…”
mentioning
confidence: 99%
“…To date, research in this field has focused on a few protein candidates including merozoite surface protein (MSP)-1 (14), MSP-2 (8), MSP-3 (15)(16)(17)(18), apical membrane Ag 1 (AMA-1) (19), erythrocyte binding Ag 175 (EBA-175) (20), glutamate-rich protein (GLURP) (15,21), and serine repeat Ag 5 (SERA5) (22). These Ags are all merozoite proteins, either located on the merozoite surface or contained within apical invasion organelles.…”
mentioning
confidence: 99%
“…The region represents a tandem repeat and it has been reported that proteins with repeats are immunogenic and effective in clearance mechanisms (Horii et al, 2010). In this study, the repeat region of sheath protein Shp-1 was cloned, expressed and its reactivity in filarial clinical population was evaluated.…”
Section: Discussionmentioning
confidence: 99%
“…However, sero-positivity rate against the Nterminal domain of P. falciparum SERA5 was observed to be relatively low (Fig. 11.; Aoki et al, 2002;Horii et al, 2010). Fig.…”
Section: Conclusion and Open Issues In Sera Studymentioning
confidence: 98%
“…Parasite egress from the host cell is an important process that remains poorly understood. P. falciparum SERA5 is a vaccine candidate molecule now on clinical trial in Uganda (Horii et al, 2010). Serum antibodies against the N-terminal domain of P. falciparum SERA5 in individuals living in malaria endemic area protect infants from clinical malaria and inhibit in vitro parasite growth (Okech et al, 2001(Okech et al, , 2006Aoki et al, 2002;Horii et al, 2010).…”
Section: Conclusion and Open Issues In Sera Studymentioning
confidence: 99%
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