Evidences for Spermatozoa Toxicity and Oxidative Damage of Cadmium Exposure in Rats

Akunna, G.G.; Obikili, Emmanuel N.; Anyawu, G.E.; Esom, Emmanuel Anayochukwu

doi:10.3923/jpt.2017.50.56

Cited by 7 publications

(5 citation statements)

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“…Male reproductive system is extremely sensitive to cadmium toxicity (Akunna, Obikili, Anyawu, & Esom, ; Djuric et al, ; Farombi et al, ). The focus of this current study is to investigate the protective effect of methanol extract of C. afer leaves on oxidative stress and testosterone testicular status, relative reduction of testicular mass and testis morphological changes, the result obtained shows that sperm count, viability and motility were significantly reduced in cadmium‐treated rats, while sperm volume was zero in cadmium‐intoxicated rat treated with high dose of plant extract.…”

Section: Discussionmentioning

confidence: 99%

High dose of standardised extract ofCostus aferleaves potentiates cadmium reproductive toxicity in Wistar rats

Atere

Akinloye

2019

Andrologia

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Protective effects of standardised extract of Costus afer leaves (CAME), an extract with good antioxidants on cadmium-induced reproductive toxicity in male rats, were investigated in this study. Forty-two adult male Wistar rats were randomly divided into six groups and were treated every day regularly for 4 weeks. G1 (control) rats received 1 ml of vehicle treatment. G2 rats were intoxicated with 2.5 mg kg −1 day −1 s.c cadmium chloride for 1 week. G3 and G4 rats were intoxicated with cadmium as in G2 rats and were treated orally with 100 and 200 mg/kg bwt/day of CAME, respectively, for 4 weeks. Group G5 and G6 rats were orally treated with 100 and 200 mg kg −1 day −1 bwt of CAME, respectively, for 4 weeks. Significant changes (p < 0.05) in andrological parameters (sperm count, sperm morphology, serum testosterone and nitric oxide concentration) and testicular antioxidant parameters (reduced glutathione, lipid peroxidation and activities of catalase, glutathione S-transferase and glutathione peroxidase) caused by Cd toxicity were improved in cadmium-intoxicated rats treated with 100 mg/kg body weight of CAME. Administration of 200 mg/ kg body weight of CAME to cadmium-intoxicated rats potentiated reproductive toxic effects of cadmium. In conclusion, lower dose of CAME is preferred over high dose in treatment of cadmium-induced reproductive toxicity in rats. K E Y W O R D Scadmium, Costus afer, reproductive toxicity, testes

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Section: Discussionmentioning

confidence: 99%

High dose of standardised extract ofCostus aferleaves potentiates cadmium reproductive toxicity in Wistar rats

Atere

Akinloye

2019

Andrologia

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“…MDA is produced due to the degradation of the peroxides of unsaturated fatty acids. It is used as a biomarker to determine the rate of oxidative damage to lipids, the damage caused by lipid peroxidation is the most important factor for testicular dysfunction and changes in the antioxidant defense system lead to decrease in intracellular glutathione, catalase, albumin and fructose concentrations in the testes [12] Membrane integrity decreased, mostly in the part of the mitochondrial after cadmium exposure to spermatozoa [13]. It also affects the ubiquitin adenosine triphosphate (ATP) depend on the proteolytic pathway, which ATP is the most important energy source for sperm motility.…”

Section: Resultsmentioning

confidence: 99%

Induction of Testicular Degeneration syndrome via Cadmium Chloride in male Albino rats

Al-Sharafi

Alobaidy²

2022

Kufa Jou. Vete. Med. Sci.

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This study was designed to induction of testicular degeneration syndrome (TDS) in male rats by cadmium chloride and identified the best concentration of induction for this syndrome. The effective dose of cadmium chloride (CdCl₂) was determined by used fifteen males rats and where divided into three equal groups treated with CdCl₂ in a concentration (1, 2 and 3)mg/kg B.W. I.P. one /week for two weeks. Later the experimental animals was scarified and testis was took for measuring the antioxidant parameters via evaluated of glutathione GSH, malondialdehyde MDA, catalse, albumin, fructose concentrations and aminotransferase activity (ALT and AST). According to this result the lowest observed adverse effective dose (LOAEL) of cadmium chloride that induced testicular degeneration in male rats was found to be 1mg/kg B.W. I.p. one /week for two weeks.

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“…Primary sexual cells are transmitted throughout the fetal period to the seminal tubules, which initiate their normal growth and reproduction after birth and at the onset of puberty [ 19 ]. The most common cause of infertility is the disruption of sperm production and performance during the spermatogenesis cycle [ 16 ]. One of the most important causes of infertility is ROS [ 5 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to that, it was reported that spermatogenesis is damaged by free radical toxicity. Spermatogenesis is a cellular procedure by which a subpopulation of type A spermatogonia, namely spermatogonia stem cells, divide and differentiate into sperm [ 15 , 16 ]. Spermatogonia stem cells are held in a specialized microenvironment called the niche that involves a combination of the male germ cells, somatic cells, and extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle

et al. 2018

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Introduction Testicular tissue is part of the reproductive system that some mineral compounds such as cadmium chloride (CdCl2) destroy. Green tea (Camellia sinensis) extract can reduce the tissue damage caused by toxins due to its antioxidant properties. The aim of this study was to evaluate the effect of green tea extract on sperm quality in cadmium chloride toxicity. Materials and Methods In the present study, male Wistar rats were allotted randomly into four groups, namely control group (C), CdCl2 (1.5mg/kg), GT 1.5% (w/v) and in combinationCdCl2+GT groups. CdCl2 was injected intraperitoneally (1.5 mg /kg) whereas the green tea extract was administrated orally. At 13, 25 and 49 days after treatment, the rats were euthanized and the reproductive organs (testes, epididymis) were excised and used for sperm analysis and histo-morphometric examinations. Results The mean of the diameter of seminiferous tubes, the number of spermatogonia, Sertoli, Leydig cells and thickness of the germinal layer in the testis were significantly increased (P<0.05) in all groups compared to the CdCl2 group (P<0.05). Sperm motility, sperm count and testosterone were significantly decreased in the CdCl2 group compared to all groups of treatment (p<0.05). The mean of MDA was significantly increased in the CdCl2 group compared to other groups (p<0.05). Conclusion Green tea has an antioxidant effect that reduces the effects of free oxygen radicals produced from toxins such as cadmium chloride. In addition, it could decrease lipid peroxidation of the cell membrane and ultimately prevent the destruction of tissues in the long run.

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Evidences for Spermatozoa Toxicity and Oxidative Damage of Cadmium Exposure in Rats

Cited by 7 publications

References 0 publications

High dose of standardised extract ofCostus aferleaves potentiates cadmium reproductive toxicity in Wistar rats

High dose of standardised extract ofCostus aferleaves potentiates cadmium reproductive toxicity in Wistar rats

Induction of Testicular Degeneration syndrome via Cadmium Chloride in male Albino rats

Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle

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