Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle

Mahmoudi, Reza; Azizi, Arash; Abedini, Seyedeh Sedigheh; Jahromi, Hemayatkhah; Abidi, Hassan; M, Jafari Barmak

doi:10.25122/jml-2018-0005

Cited by 34 publications

(17 citation statements)

References 25 publications

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“…Thereby, administration of antioxidants increased semen parameters, including the percentage of motile spermatozoa (Ahmadi et al, 2016). Antioxidants in green tea could prevent oxidative damage due to free radicals on several spermatozoa parameters, such as motility, abnormalities, and concentration (Mahmoudi et al, 2018). However, administration higher dose (60 mg/kg BW) of GTE showed a decrease in the percentage of spermatozoa plasma membrane integrity, viability, and motility.…”

Section: Discussionmentioning

confidence: 96%

Green tea (Camellia sinensis) leaf extract maintained spermatozoa plasma membrane integrity, viability, and motility of mice (Mus musculus) exposed to cigarette smoke

Silviani¹,

Sukmanadi²,

Kurnijasanti³

et al. 2022

Ovz

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Cigarette smoke chemicals caused oxidative stress by increasing Reactive Oxygen Species (ROS). ROS exposure could be neutralized by antioxidants, such as green tea (Camellia sinensis) leaf extract. This study aimed to determine the effect of green tea extract (GTE) on spermatozoa plasma membrane integrity, spermatozoa viability, and spermatozoa motility of mice (Mus musculus) exposed to cigarette smoke. Twenty-five mice were randomly divided into five groups. Group C- mice were given a placebo (1% Sodium carboxymethyl cellulose, Na-CMC). Group C+, T1, T2, and T3 mice were exposed to cigarette smoke and given 0, 20, 40, and 60 mg/kg BW GTE respectively. Cigarette smoke exposure used a clove cigarette per day. GTE in 1% Na-CMC solution was administered at 0.5 mL orally using a gastric probe. The treatment was conducted daily for 36 days, and on day 37, all mice were euthanized for spermatozoa evaluation. The results showed that all parameters evaluated in the C+ group were lower (p <0.05) than in C- group. Administration of GTE in the T2 group increased (p <0.05) all parameters compared to mice in the C+ group. However, administration of GTE to mice in the T3 group caused a decrease (p <0.05) in all parameters than those of the T2 group and was not significantly different (p >0.05) compared to those of the C+ group. It could be concluded that the administration of GTE at 40 mg/kg BW has maintained the spermatozoa plasma membrane integrity, spermatozoa viability, and spermatozoa motility of mice exposed to cigarette smoke.

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Section: Discussionmentioning

confidence: 96%

Green tea (Camellia sinensis) leaf extract maintained spermatozoa plasma membrane integrity, viability, and motility of mice (Mus musculus) exposed to cigarette smoke

Silviani¹,

Sukmanadi²,

Kurnijasanti³

et al. 2022

Ovz

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“…Cadmium is found in batteries, pigments, metal coatings, plastics, and in cigarette smoke. The studies about cadmium exposure on Rats reported that sperm count, motility and vitality as well as morphologically normal sperm and testosterone was significantly reduced (Adamkovicova et al, 2016; Asadi et al, 2013; Mahmoudi et al, 2018). A study conducted on mice suggested that Cd‐induced phosphorylation of proteins might act as an engine to inhibit energy metabolism and decrease sperm motility (Wang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Seminal trace elements and their relationship with sperm parameters

et al. 2022

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Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due to rapid industrial development and technology has raised the questions: Is there a relationship between sperm parameters and these substances, and if so, in what extent? Results of studies on the subject reported conflicting results, many of which were not investigated in the seminal plasma. The aim of the current study was to evaluate the relationship between 23 metals and trace elements in human seminal plasma and semen parameters many of

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“…The standard dose is calculated as the average dosing of body weight-based and body surface area-based dosing (Mokhimar et al, 2020). Two sacrifice days have been placed, the first was on day 15 to evaluate the acute effects, and the second was on day 60 from the first day of treatment, to follow the sperm cycle from the start of spermatogenesis to sperm maturation (Mahmoudi et al, 2018). We observed a significant decrease in sexual organ weight (testis, epididymis) and sperm parameters (count, motility, viability) after treatment with Ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

The protective potential of ginseng on ciprofloxacin-induced male gonadotoxicity.

Mokhimar

Elsawah

Kandiel

et al. 2022

Benha Veterinary Medical Journal

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Drug-induced infertility is an important etiology and a common side effect. It is, therefore, important to develop newer pharmacological approaches to vanquish this bad effect. The aim of the present study is to evaluate the possible protective potential of ginseng against ciprofloxacin-induced male gonadotoxicity. Sixty adult Wister albino male rats (8 weeks old, 200 ± 20gm) were randomly divided into six groups of tens. Groups 1 and 2 received 78.23 and 156.46mg/kg/day of ciprofloxacin, respectively. Groups 3, 4 and 5 received 156.46 mg/kg/day of ciprofloxacin plus 100 mg/kg/day ginseng, 200mg/kg/day ginseng, and 100 mg/kg/day vitamin E, respectively. However, the sixth group served as control and received NS and CMC. All treatment given orally for 14 days. Half of the animals of each group has been sacrificed on the day 15, while the second half was sacrificed on the day 60 from the start of the treatment, after blood sampling. Immediately after dissection, testis, epididymis, prostate, and seminal vesicle were removed and weighted. Reproductive organ weights were decreased, sperm parameters were impaired and FSH and LH levels were increased in groups 1 and 2 but still normal in groups 3, 4 and 5 on the two sacrifice days. Testosterone level was significantly decreased in groups 1 and 2. However, higher levels were shown with low and high doses of ginseng treatment. Adding ginseng or vitamin E could protect against ciprofloxacin-induced infertility in the two sacrifice days. Fluoroquinolones Panax ginseng Reproduction Spermatogenesis

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Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle

Cited by 34 publications

References 25 publications

Green tea (Camellia sinensis) leaf extract maintained spermatozoa plasma membrane integrity, viability, and motility of mice (Mus musculus) exposed to cigarette smoke

Green tea (Camellia sinensis) leaf extract maintained spermatozoa plasma membrane integrity, viability, and motility of mice (Mus musculus) exposed to cigarette smoke

Seminal trace elements and their relationship with sperm parameters

The protective potential of ginseng on ciprofloxacin-induced male gonadotoxicity.

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