Evidence that Tissue Mast Cells Derive from Mononuclear Phagocytes

Czarnetzki, Beate M.; Sterry, Wolfram; Bazin, Hervé; Kalveram, K. J.

doi:10.1159/000232986

Cited by 32 publications

(21 citation statements)

References 8 publications

(13 reference statements)

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“…Mast cells appeared 2 wk after starting the culture of such mast cell-depleted peritoneal cells. Since most of mast ceil-depleted peritoneal ceils showed phagocytic activity at the start of the culture, they claimed that mononuclear phagocytes were mast cell precursors (11). In this point, their result is not consistent with the present result, because the removal of phagocytic ceils increased the concentration of mast cell precursors (Table V).…”

Section: Discussioncontrasting

confidence: 87%

See 1 more Smart Citation

Proliferation of peritoneal mast cells in the skin of W/Wv mice that genetically lack mast cells.

Sonoda¹,

Kanayama²,

Hara³

et al. 1984

The Journal of Experimental Medicine

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Presence of mast cell precursors in the mouse peritoneal cavity was demonstrated, and the precursors were characterized. When a cell suspension, containing mast cell precursor(s), was directly injected into the skin of genetically mast cell-deficient WBB6F1 (WB X C57BL/6)-W/Wv mice, a cluster composed of approximately 2,000 mast cells appeared at the injection site. By determining the proportion of injection sites at which the mast cell cluster appeared, the concentration of mast cell precursors can be calculated by limiting dilution analysis. The concentration in the peritoneal cavity was about five times as great as the concentration in the bone marrow. Although peritoneal mast cell precursors were shown to originate from the bone marrow, physical characterization revealed that the peritoneal precursors differed from the marrow precursors. The peritoneal precursors were less susceptible to irradiation than the marrow precursors; the former were heavier than the latter. When a 95% pure mast cell suspension was prepared from the peritoneal cells by the removal of phagocytes and the density gradient centrifugation, 1 out of 16 cells had the potentiality to make a mast cell cluster in the skin of the W/Wv mice. Moreover, when a single mast cell was identified under the phase contrast microscope and picked up with the micromanipulator, 1 out of 17 mast cells made the cluster. This indicated that some peritoneal mast cells kept extensive proliferative potentiality even after morphological differentiation. In other words, some peritoneal mast cells themselves may function as the committed precursors.

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Section: Discussioncontrasting

confidence: 87%

“…Czarnetski et al (11) have also shown the presence of mast cell precursors in the peritoneal cavity of rats. They obtained mast cell-depleted peritoneal cells 5 d after intraperitoneal injection of distilled water.…”

Section: Discussionmentioning

confidence: 93%

Proliferation of peritoneal mast cells in the skin of W/Wv mice that genetically lack mast cells.

Sonoda¹,

Kanayama²,

Hara³

et al. 1984

The Journal of Experimental Medicine

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“…They resemble mac rophages regarding their size, mononuclear morphology, surface markers, enzyme con tents and their ability to phagocytize a great variety of agents and particles [3,[6][7][8][9], The latter activity is, however, reduced with in creasing maturity in cultured mast cells [8]. [15] In murine models, immature mast cells have been shown to develop in intestinal mucosa under the influence of T lympho cyte-derived factors and are therefore also called T-dependent mast cells [5].…”

Section: Mast Cell Ontogeny and Differentiationmentioning

confidence: 99%

“…While the significance of the T cell-de rived interleukins regarding their effect on human connective tissue mast cells remains thus unclear, new light has been shed on the problem from another angle: Over the past 10 years, there is increasing evidence that fibroblasts are the main source of mast cell stimuli for differentiation, proliferation and maturation [3,7,8,20], The recently cloned IL-11 from fibroblasts (table 2) which is also a megakaryocyte growth factor [ 17], may be one of these agents. Increased secretion of fibroblast-derived growth factors may ex plain the increase of mast cells in fibrous hyperplasia due to scleroderma and wound healing [21], In neurofibromas, nerve growth factor might also contribute to increases of mast cells [19,22],…”

Section: Mast Cell Ontogeny and Differentiationmentioning

confidence: 99%

Mast Cells and Their Mediators in Immediate and Delayed Immune Reactions

Möller

Grabbe²,

Czarnetzki³

1991

Skin Pharmacol Physiol

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Tissue mast cells and the closely related blood basophils are distinguished by their special mediators and their high-affinity IgE membrane receptors. These properties have made the cells be viewed traditionally as effector cells of immediate-type hypersensitivity reactions. More recently, mast cells have been shown to develop from the myeloid series of the bone marrow under the influence of interleukins 3, 4, 6, 9, 10 and 11. Mast cell and basophil lines of murine and human origin have also been shown to express and release interleukins 1, 3, 4, 5, 6, 8, tumor necrosis factor-α, granulocyte-macrophage colony-stimulizing factor and interferon-γ. Certain cytokines are also able to induce mediator release from mast cells. Furthermore, mast cells have in the past been shown to be modestly phagocytic and to express major histocompatibility complex class II membrane markers after appropriate stimulation. These findings show that mast cells are intricately associated with immune reactions and suggest that they may not only sustain and modulate but possibly also initiate immune responses.

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“…These mast cells were suggested to be derived from T lym phocytes, fibroblasts, or macrophages [2][3][4], It is now accepted, however, that mast cells are derived from pluripotential hematopoietic cells in the bone marrow [5][6][7]. This was demonstrated by Kitamura with in vivo experiments using genetically mast cell-deficient mutant mice and their congeneic normal littermates.…”

mentioning

confidence: 99%

Early Development of Mast Cells

Rottem

Kirshenbaum²,

Metcalfe³

1991

Int Arch Allergy Immunol

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Mast cells originate from pluripotential cells in the bone marrow. Specifically, human mast cells originate from CD 34-positive progenitor cells. Mast cell proliferation requires IL-3. In the mouse, additional mast cell growth is achieved by the addition of IL-4, and GM-CSF prevents mast cell proliferation. Early bone-marrow-derived mast cells can be identified by their IgE receptors, although they may not yet have the characteristic morphology of mature mast cells. Whether these early cells may by themselves have a physiologic role, remains to be determined. Mast cells persist in culture on fibroblast monolayers, in part due to the production of soluble factor(s) from the fibroblasts themselves. Final mast cell phenotype appears dependent upon the local tissue environment.

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Evidence that Tissue Mast Cells Derive from Mononuclear Phagocytes

Cited by 32 publications

References 8 publications

Proliferation of peritoneal mast cells in the skin of W/Wv mice that genetically lack mast cells.

Proliferation of peritoneal mast cells in the skin of W/Wv mice that genetically lack mast cells.

Mast Cells and Their Mediators in Immediate and Delayed Immune Reactions

Early Development of Mast Cells

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