Evidence that oxidative stress is linked to anxiety-related behaviour in mice

Rammal, Hassan; Bouayed, Jaouad; Younos, C.; Soulimani, Rachid

doi:10.1016/j.bbi.2008.06.005

Cited by 169 publications

(90 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although these data are not supportive for a role of ROS in the subordinate outcome of high-anxious rats, we cannot discard the effectiveness of other antioxidant administration regimes (i.e., other administration timing, doses, and/or chronicity). Interestingly, although there is increasing evidence linking differences in mitochondrial function and oxidative stress with clinical pathologies such as anxiety disorders (31,(45)(46)(47), here we go beyond the pathological state and show that differences in brain mitochondrial function in the NAc can be found in association with personality differences.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial function in the brain links anxiety with social subordination

Hollis

Kooij

Zanoletti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

213

257

View full text Add to dashboard Cite

Dominance hierarchies are integral aspects of social groups, yet whether personality traits may predispose individuals to a particular rank remains unclear. Here we show that trait anxiety directly influences social dominance in male outbred rats and identify an important mediating role for mitochondrial function in the nucleus accumbens. High-anxious animals that are prone to become subordinate during a social encounter with a low-anxious rat exhibit reduced mitochondrial complex I and II proteins and respiratory capacity as well as decreased ATP and increased ROS production in the nucleus accumbens. A causal link for these findings is indicated by pharmacological approaches. In a dyadic contest between anxietymatched animals, microinfusion of specific mitochondrial complex I or II inhibitors into the nucleus accumbens reduced social rank, mimicking the low probability to become dominant observed in highanxious animals. Conversely, intraaccumbal infusion of nicotinamide, an amide form of vitamin B3 known to enhance brain energy metabolism, prevented the development of a subordinate status in high-anxious individuals. We conclude that mitochondrial function in the nucleus accumbens is crucial for social hierarchy establishment and is critically involved in the low social competitiveness associated with high anxiety. Our findings highlight a key role for brain energy metabolism in social behavior and point to mitochondrial function in the nucleus accumbens as a potential marker and avenue of treatment for anxiety-related social disorders.anxiety | mitochondria | nucleus accumbens | social dominance | social competition

show abstract

Section: Discussionmentioning

confidence: 99%

Mitochondrial function in the brain links anxiety with social subordination

Hollis

Kooij

Zanoletti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

213

257

View full text Add to dashboard Cite

show abstract

“…Antioxidants are genuine phenolic substances that deactivate free radical electrons through three mechanisms: It either deactivates free radicals by hydrogen donation, or transfer antioxidants electron to inhibit or decrease activity of metals and carbonyl, or it does both previous mechanism at the same time [2] . Oxidative stress is involved in the pathology of cancer, arteriosclerosis, malaria and rheumatoid arthritis, and could play a role in neurodegenerative diseases and ageing processes [3,4] .…”

Section: P E E R R E V I E W Abstract Abstractmentioning

confidence: 99%

Chemical composition and antioxidant activity of a Lebanese plant Euphorbia macroclada schyzoceras

Farhan

Rammal

Hijazi

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

Self Cite

View full text Add to dashboard Cite

“…The extremely complex mechanisms involved in the regulation of anxiety in humans are similarly complex in rodents, and this has led to the development of translational models in mice [8][9][10] that may help to investigate the underlying negative effects of high anxiety level [4][5][6] , improve treatment and delineate the neural mechanisms of action [10,11] . Anxiety likely becomes pathological when it presents with an extreme and persistent characteristic [12] .…”

mentioning

confidence: 99%

The Impact of High Anxiety Level on Cellular and Humoral Immunity in Mice

Rammal

Bouayed

Falla³

et al. 2009

Neuroimmunomodulation

Self Cite

View full text Add to dashboard Cite

Background/Aims: In the present study, we aimed to examine whether a high anxiety level affects various parameters of immunity in mice. Methods: We used the behavioral light/dark choice test to evaluate whether high anxiety has an impact on various parameters of cellular (granulocytes, monocytes, total lymphocytes, TCD4⁺, TCD8⁺ and NK numbers) and humoral (IgA, E and G concentrations) immunity. Secondly, we investigated whether the cellular and humoral immune systems of mice with contrasting levels of anxiety responded differently to stressors (such as physical restraint) by monitoring blood markers of the both types of immunity. Results: High levels of anxiety inhibited part of the cellular and humoral immune systems by significantly decreasing total lymphocytes numbers (including TCD4⁺ and TCD8⁺) and immunoglobulin (A and E) concentrations. However, no significant changes in the number of granulocytes, monocytes or NK cells were observed. As a consequence, overall, our results suggest that high anxiety led to a decrease in the efficiency of the immune system of anxious mice. On the other hand, our findings also showed that restraint stress (acute and subacute) produced the same immunological profile as high anxiety in mice. This was independent of the animals’ anxiety status. At the same time, we observed that restraint stress produced significant increases in the levels of granulocytes and monocytes. Conclusions: High anxiety and restraint stress exerted adverse effects on cellular and humoral immunity in mice. While the effect of restraint stress was independent of the anxiety levels in mice, this stress led to an aggravation of the immune response from the high degree of anxiety. Therefore, anxious subjects could be more vulnerable to infections and inflammation, particularly when they are exposed to stressful situations.

show abstract

Evidence that oxidative stress is linked to anxiety-related behaviour in mice

Cited by 169 publications

References 30 publications

Mitochondrial function in the brain links anxiety with social subordination

Mitochondrial function in the brain links anxiety with social subordination

Chemical composition and antioxidant activity of a Lebanese plant Euphorbia macroclada schyzoceras

The Impact of High Anxiety Level on Cellular and Humoral Immunity in Mice

Contact Info

Product

Resources

About