Evidence That Neuropeptide Y Elicits Eating by Acting in the Caudolateral Paraventricular/Perifornical Hypothalamusa

Stanley, B. Glenn; Magdalin, William; Leibowitz, Sarah F.

doi:10.1111/j.1749-6632.1990.tb48995.x

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…The increases in preproNPY mRNA levels were found to be specific to the hypothalamus, and localized to the arcuate nucleus. This is an interesting observation in light of the fact that many of the fibers projecting from the arcuate terminate in the PVN (20), and local injections of NPY into the PVN have been shown to be a powerful stimulant of feeding behavior (6). Moreover, as mentioned above, chronic injection of NPY into the area of the PVN is capable of producing dramatic hyperphagia and obesity similar to that seen in the obese Zucker rat (5,9).…”

Section: Fig 2 Increased Prepronpy Mrna Expression In Female Obesementioning

confidence: 90%

“…In fact, upon injection into the caudolateral aspects of the paraventricular nucleus (PVN) (6) NPY has proven to be the most potent orexigenic agent evaluated to date (7) and is now suspected of playing an important role as a naturally occurring regulator of feeding behavior (8). Chronic administration of NPY is capable of producing long lasting hyperphagia, causing large increases in body weight, and possibly enhancing metabolic efficiency (5,9), and NPY levels in hypothalamus of obese Zucker rats have been reported to be elevated when compared to levels seen in lean animals (10).…”

mentioning

confidence: 99%

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Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

et al. 1990

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Neuropeptide Y (NPY) is a potent orexigenic agent capable of producing hyperphagia and obesity. NPY-containing neurons project from the hypothalmic arcuate nucleus to the paraventricular nucleus, an area known to be sensitive to the orexigenic effects of NPY. In this study we investigated the possibility that preproNPY messenger RNA (mRNA) content may be altered in obese Zucker rats compared to that of their lean littermates. Total RNA was isolated from hypothalamic dissections from male and female, obese and lean Zucker rats. RNA was also isolated from dissections of: olfactory bulb, entorhinal cortex, hippocampus, and striatum of female obese and lean rats. PreproNPY mRNA content was determined by solution hybridization-RNase protection analysis. The results revealed a 2- to 3-fold increase in preproNPY mRNA levels in the hypothalamus of obese animals compared to lean. The increase was observed in both sexes and was specific to the hypothalamus. In situ hybridization localized this increase to the arcuate nucleus. An additional RNase protection study was pursued to investigate the effects of 72 h food deprivation on hypothalamic preproNPY mRNA levels in lean and obese animals. Lean animals displayed an approximate 2-fold increase in preproNPY mRNA content, whereas obese animals showed no significant increase after food deprivation. These data are consistent with the hypothesis that NPY projections within the hypothalamus are involved in regulating feeding behavior and weight gain, and that disturbed regulation of hypothalamic NPY expression may play a role in the etiology of obesity in the genetically obese Zucker rat.

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Section: Fig 2 Increased Prepronpy Mrna Expression In Female Obesementioning

confidence: 90%

mentioning

confidence: 99%

Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

et al. 1990

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“…Several reports demonstrated that NPY is a potent regulator of feeding, energy expenditure, and fat storage (Clark et al, 1984;Stanley et al, 1990;Billington and Levine, 1992). There is now considerable evidence demonstrating that hypothalamic NPY is responsive to changes in energy balance and leptin.…”

Section: Neuropeptide Ymentioning

confidence: 99%

The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function.

1999

Journal of Animal Science

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The recently discovered protein leptin has a molecular mass of 16 kDa, consists of 146 amino acids, and is synthesized and secreted by adipose tissue. Leptin affects feed intake, the neuroendocrine-axis, and immunological processes. The protein was first identified as the gene product that is deficient in the obese ob/ob mouse. Leptin serves as a circulating signal of nutritional status and plays a pivotal role in regulation of body weight, energy expenditure, growth, and reproduction.

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“…Contrary to leptin, NPY is a potent regulator of food intake, energy expenditure, and fat storage (Clark et al 1984, Stanley et al 1990, Billington and Levine 1992. There is now considerable evidence demonstrating that hypothalamic NPY is responsive to changes in energy balance and serum leptin concentrations.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…Neuropeptide Y is a member of a family of pancreatic peptides, and is widely distributed in the central nervous system (CNS) and, in particular, the hypothalamus (Tatemoto 1982, Bush-Sorensen et al 1989). Contrary to leptin, NPY is a potent regulator of food intake, energy expenditure, and fat storage (Clark et al 1984, Stanley et al 1990, Billington and Levine 1992. There is now considerable evidence demonstrating that hypothalamic NPY is responsive to changes in energy balance and serum leptin concentrations.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Role of Leptin in Modulating Neuroendocrine Function: A Metabolic Link between the Brain‐Pituitary and Adipose Tissue

Barb

Barrett

Kraeling

et al. 1999

Reprod Domestic Animals

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Evidence That Neuropeptide Y Elicits Eating by Acting in the Caudolateral Paraventricular/Perifornical Hypothalamusa

Cited by 10 publications

References 5 publications

Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function.

Role of Leptin in Modulating Neuroendocrine Function: A Metabolic Link between the Brain‐Pituitary and Adipose Tissue

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