Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system

Choi, Sunga; Jung, Se-Yeon; Rhim, Hyewhon; Jeong, Soon‐wuk; Lee, Sang-Mok; Nah, Seung‐Yeol

doi:10.1016/s0024-3205(00)00682-2

Cited by 12 publications

(3 citation statements)

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“…Mice were allowed free access to both compartments when the guillotine door was open during the pretesting (days 1 and 2). Then the mice were injected with morphine before confinement in the white compartment for 60 min (days 4, 6, 8, 10) and injected with saline before confinement in the black compartment for 60 min (days 5,7,9,11). In the testing phase (day 12), the time spent by mice in each compartment was recorded for 15 min.…”

Section: Lettermentioning

confidence: 99%

Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Guo

Wang²,

Yang³

et al. 2004

Planta med

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Ginsenosides, the main effective components of the root of Panax ginseng, have been reported to modulate morphine action. In the present study, ginsenosides Rd, Rb2, Rgl and Re were divided into two groups according to their effects in mice on morphine-induced hyperactivity and conditioned place preference (CPP). Ginsenosides Rd, Rb2, Rgl had no effect on morphine-induced hyperactivity, but antagonized morphine-induced CPP. On the contrary, ginsenoside Re increased morphine-induced hyperactivity whereas it showed no effect on morphine-induced CPP.Furthermore, Re antagonized the inhibitory effect of the mixture involving Rd, Rb2 and Rgl on the morphine action. These results suggest that ginsenosides with different structures have antagonizing properties in the regulation of morphine-induced reinforcement.

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Section: Lettermentioning

confidence: 99%

Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Guo

Wang²,

Yang³

et al. 2004

Planta med

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“…They also have an antinociceptive effect on various animal models [4-8]. In practice, ginseng has been used to alleviate a variety of pain in traditional folk medicines since administration of ginseng extracts promptly produces antinociception and prevents the opioid tolerance caused by chronic treatment with morphine at spinal cord [7]. Moreover, ginsenosides recently were known to inhibit voltage-dependent channels in peripheral sensory neurons [9,10].…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth

Jung

Seong

Moon

et al. 2013

Korean J Physiol Pharmacol

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The purpose of this study is to investigate the antinociceptive effects of ginsenosides on toothache. c-Fos immunoreactive (IR) neurons were examined after noxious intrapulpal stimulation (NS) by intrapulpal injection of 2 M KCl into upper and lower incisor pulps exposed by bone cutter in Sprague Dawley rats. The number of Fos-IR neurons was increased in the trigeminal subnucleus caudalis (Vc) and the transitional region between Vc and subnucleus interpolaris (Vi) by NS to tooth. The intradental NS raised arterial blood pressure (BP) and heart rate (HR). The number of Fos-IR neurons was also enhanced in thalamic ventral posteromedial nucleus (VPMN) and centrolateral nucleus (CLN) by NS to tooth. The intradental NS increased the number of Fos-IR neurons in the nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM), hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN), central cardiovascular regulation centers. Ginsenosides reduced the number of c-Fos-IR increased by NS to tooth in the trigeminal Vc and thalamic VPMN and CLN. Naloxone, an opioid antagonist, did not block the effect of ginsenoside on the number of Fos-IR neurons enhanced by NS to tooth in the trigeminal Vc and thalamic VPMN and CLN. Ginsenosides ameliorated arterial BP and HR raised by NS to tooth and reduced the number of Fos-IR neurons increased by NS to tooth in the NTS, RVLM, hypothalamic SON, and PVN. These results suggest that ginsenosides have an antinociceptive effect on toothache through non-opioid system and attenuates BP and HR increased by NS to tooth.

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“…To date, tens and hundreds of constituents have been isolated and identified from each of the comprised drugs of JTT. Among these chemical constituents, tanshinones, triterpene saponins and alkaloids were thought to be responsible for their biological effects in the treatment of drug addiction 7–9. However, there have been no reports about an integrative study of the constituents in the formula which is not simply a mixture of the individual drugs, but an integrated prescription.…”

mentioning

confidence: 99%

Gastrointestinal stromal tumours (Br J Surg 2003; 90: 1178–1186)

Amalesh

2004

British Journal of Surgery

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Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system

Cited by 12 publications

References 0 publications

Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth

Gastrointestinal stromal tumours (Br J Surg 2003; 90: 1178–1186)

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