Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Guo, Ming; Wang, Jinhui; Yang, Jingyu; Zhu, Dan; Xu, Nan‐Jie; Pei, Gang; Wu, Chunfu; Li, Xian

doi:10.1055/s-2004-827197

Cited by 5 publications

(5 citation statements)

References 7 publications

(14 reference statements)

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“…(1998c, 1999a) showed that ginseng total saponin did not produce an effect at 50 and 100 mg/kg ip. Guo et al . (2004) found that the ginsenosides Rb2, Rd, Rg1 and Re (0.5 and 1 µmol/kg po) and 1:1:1:1 or 1:1:1:2 mixtures of these compounds did not produce an effect.…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

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REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

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Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

“…(1998c) showed that ginseng total saponin (50, 100 mg/kg ip) blocked morphine (5 mg/kg ip)‐induced CPP. Guo et al . (2004) reported that morphine (5 mg/kg sc)‐induced CPP was blocked by the ginsenosides Rd, Rg1 and Rb2, but not Re (0.5 and 1 µmol/kg po).…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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“…Their chemical and pharmacological properties have been reported by investigators in many countries. Recently, several studies suggest that Panax ginseng (PG) and its ginsenosides can act on the central dopaminergic system [7,13]. Many studies have also reported that Panax ginseng inhibited the hyperactivity and the conditioned place preference of morphine, cocaine, and methamphetamine [9][10][11].…”

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confidence: 99%

Wild Ginseng Attenuates Repeated Morphine-Induced Behavioral Sensitization in Rats

Lee

Kwon²,

Yeom³

et al. 2011

J. Microbiol. Biotechnol.

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Many studies have suggested that the behavioral and reinforcing effects of morphine are induced by hyperactivation of the mesolimbic dopaminergic system, which results in increases in locomotor activity, c-Fos expression in the nucleus accumbens (NAc), and tyrosine hydroxylase (TH) in the ventral tegmental area (VTA). In order to investigate the effect of wild ginseng (WG) on treating morphine addiction, we examined the behavioral sensitization of locomotor activity and c-Fos and TH expression in the rat brain using immunohistochemistry. Intraperitioneal injection of WG (100 and 200 mg/kg), 30 min before administration of a daily injection of morphine (40 mg/kg, s.c.), significantly inhibited morphine-induced increases in c-Fos expression in NAc and TH expression in VTA as well as in locomotor activity, as compared with Panax ginseng. It was demonstrated that the inhibitory effect of WG on the behavioral sensitization after repeated exposure to morphine was closely associated with the reduction of dopamine biosynthesis and postsynaptic neuronal activity. It suggests that WG extract may be effective for inhibiting the behavioral effects of morphine by possibly modulating the central dopaminergic system and that WG might be a useful resource to develop an agent for preventing and treating morphine addiction.

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“…Ginsenosides Rh2, Rg3, and compound K have been reported for apoptosis [16] , [17] and anticancer [18] , [19] , [20] , anti-inflammatory [21] , [22] , and antidepressant-like effects [23] . Previous reports indicated that ginsenosides with different structures have antagonizing properties in the regulation of morphine-induced reinforcement [24] . Despite the potential effects of ginsenosides on morphine dependence and tolerance reported so far, little is known regarding the effects of red ginseng extract (RGE) on morphine-induced behavioral disorders.…”

Section: Introductionmentioning

confidence: 99%

Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

Yayeh

Yun

Jang

et al. 2016

Journal of Ginseng Research

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BackgroundRed ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats.MethodsWhile mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions.ResultsWhereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects.ConclusionRGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.

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Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Cited by 5 publications

References 7 publications

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Wild Ginseng Attenuates Repeated Morphine-Induced Behavioral Sensitization in Rats

Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

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