Evidence regarding an effect of marine n‐3 fatty acids on preterm birth: a systematic review and meta‐analysis

Salvig, Jannie Dalby; Lamont, Ronald F.

doi:10.1111/j.1600-0412.2011.01171.x

Cited by 73 publications

(54 citation statements)

References 71 publications

(138 reference statements)

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“…It showed that omega-3 during pregnancy reduced the rate of preterm birth and increased birth weight. 37 The Cochrane Review on omega-3 supplementation in pregnancy included also RCTs with PUFAs as a control and RCTs with prostaglandin precursor as treatment. It showed a small but consistent increase in the mean length of gestation.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth

Saccone

Berghella

2015

Obstetrics &Amp; Gynecology

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Section: Discussionmentioning

confidence: 99%

Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth

Saccone

Berghella

2015

Obstetrics &Amp; Gynecology

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“…However, in the shorter term, a meta-analysis of 921 women illustrated that risk of pre-term birth, a known risk factor for future visceral adiposity and metabolic dysfunction, was successfully reduced by n-3 PUFA supplementation (148) , although the mechanisms are not yet established. Data emerging from RCT are somewhat in conflict with animal studies.…”

Section: Gestationmentioning

confidence: 99%

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

et al. 2014

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Evidence suggests that at a population level, childhood and adolescent obesity increase the long-term risk of chronic diseases such as type 2 diabetes and CVD. At an individual level, however, the metabolic consequences of obesity in youth vary immensely. Despite comparable BMI, some adolescents develop impaired glucose tolerance while others maintain normal glucose homeostasis. It has been proposed that the variation in the capacity to store lipid in the subcutaneous adipose tissue (SAT) may partially discriminate metabolically healthy from unhealthy obesity. In positive energy balance, a decreased capacity to expand SAT may drive lipid accumulation to visceral adipose tissue, liver and skeletal muscle. This state of lipotoxicity is associated with chronic low-grade inflammation, insulin resistance and dyslipidaemia. The present review examines the differential adipose tissue development and function in children and adolescents who exhibit metabolic dysregulation compared with those who are protected. Additionally, the role of manipulating dietary fat quality to potentially prevent and treat metabolic dysfunction in obesity will be discussed. The findings of the present review highlight the need for further randomised controlled trials to establish the effect of dietary n-3 PUFA on the metabolic phenotype of obese children and adolescents. Furthermore, using a personalised nutrition approach to target interventions to those at risk of, or those with established metabolic dysregulation may optimise the efficacy of modifying dietary fat quality.

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“…In their meta-analysis of RCTs including pregnant women regardless of their risk for preterm delivery,Makrides et al (2009) concluded that not clear difference in the relative risk of preterm birth existed between women supplemented or not with marine oil, even if women supplemented had a lower risk of early preterm birth. A more recent meta-analysis, including low and high risk women for preterm birth, demonstrated that supplementation with marine n-3 fatty acids reduced the rate of preterm birth both before 34 and 37 weeks of gestation, and significantly increased the mean birth weight(Salvig and Lamont, 2011). No effect of n-3 LC-PUFA supplementation was found in women with low-risk pregnancies in the meta-analysis of 6…”

mentioning

confidence: 95%

Pregnancy and Infants’ Outcome: Nutritional and Metabolic Implications

Berti

Cetin

Agostoni

et al. 2014

Critical Reviews in Food Science and Nutrition

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Pregnancy is a complex period of human growth, development, and imprinting. Nutrition and metabolism play a crucial role for the health and well-being of both mother and fetus, as well as for the long-term health of the offspring. Nevertheless, several biological and physiological mechanisms related to nutritive requirements together with their transfer and utilization across the placenta are still poorly understood. In February 2009, the Child Health Foundation invited leading experts of this field to a workshop to critically review and discuss current knowledge, with the aim to highlight priorities for future research. This paper summarizes our main conclusions with regards to maternal preconceptional body mass index, gestational weight gain, placental and fetal requirements in relation to adverse pregnancy and long-term outcomes of the fetus (nutritional programming). We conclude that there is an urgent need to develop further human investigations aimed at better understanding of the basis of biochemical mechanisms and pathophysiological events related to maternal-fetal nutrition and offspring health. An improved knowledge would help to optimize nutritional recommendations for pregnancy.

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Evidence regarding an effect of marine n‐3 fatty acids on preterm birth: a systematic review and meta‐analysis

Abstract: Marine n-3 fatty acids administered in pregnancy reduce the rate of preterm birth and increase birthweight.

Cited by 73 publications

References 71 publications

Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth

Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

Pregnancy and Infants’ Outcome: Nutritional and Metabolic Implications

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