Evidence of the involvement of biogenic amines in the antinociceptive effect of a vouacapan extracted from Pterodon polygalaeflorus Benth

Duarte, Igor Dimitri Gama; Ferreira-Alves, Dalton L.; Veloso, Dorila Piló; Nakamura-Craig, Meire

doi:10.1016/s0378-8741(96)01465-1

Cited by 35 publications

(32 citation statements)

References 14 publications

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“…Pterodon pubescens Benth., popularly known as sucupira-branca, is native to the Brazilian Cerrado (Lorenzi 1998) and is important in folk and conventional medicine in this country. The oil from sucupira-branca, obtained from samara fruits, is used to treat rheumatism (Correa 1984), arthritis (Coelho et al 2001), and schistosomiasis (Katz et al 1993) and shows anti-inflammatory (Nunan et al 1982) and analgesic (Duarte et al 1996) properties.…”

Section: Introductionmentioning

confidence: 99%

Oil Glands in Pterodon pubescens Benth. (Leguminosae-Papilionoideae): Distribution, Structure, and Secretion Mechanisms

Rodrigues

Machado

2012

International Journal of Plant Sciences

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Section: Introductionmentioning

confidence: 99%

Oil Glands in Pterodon pubescens Benth. (Leguminosae-Papilionoideae): Distribution, Structure, and Secretion Mechanisms

Rodrigues

Machado

2012

International Journal of Plant Sciences

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“…Hydroalcoholic infusions of the seeds are used in folk medicine for their anti-rheumatic, analgesic and anti-infl ammatory properties (Brito & Brito, 1993;Duarte et al, 1996). Chemical studies on genus Pterodon have shown the presence of alkaloid compounds in the bark (Torrenegra et al, 1989), isofl avone and some triterpenes in the wood (Marques et al, 1998), diterpenes (Fascio et al, 1976;Arriaga et al, 2000) and isofl avones in seed oil (Braz-Filho et al, 1971).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Dutra¹,

Pittella²,

Dittz³

et al. 2012

Rev. bras. farmacogn.

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Pterodon emarginatus Vogel, Fabaceae, is a native aromatic tree distributed by central region of Brazil. Hydroalcoholic infusions of the seeds are used in folk medicine for their anti-rheumatic and anti-inflammatory properties. The objective of this work was identified the chemical components and verify the cytotoxic effect of the essential oil (EO) from P. emarginatus seeds. Thus, the EO of P. emarginatus seeds was analyzed by GC/MS analysis followed by brine shrimp lethality test and cytotoxic activity against tumor cell lines and human peripheral mononuclear blood cells (PBMC). The cancer cell lines tested were C 6 (rat glioma), MeWo (human melanoma), CT 26 .WT (mouse colon carcinoma), MDA (human breast cancer), A 549 (human lung carcinoma), B 16 -F 1 (mouse melanoma), CHO-K1 (hamster ovary cell) and BHK-21 (hamster kidney fibroblast). Eleven compounds were identified by GC and CG/MS analyses. The main compounds with concentrations higher than 5% were β-elemene (15.3%), trans-caryophyllene (35.9%), α-humulene (6.8%), germacrene-D (9.8%), bicyclo germacrene (5.5%) and spathulenol (5.9%). The EO of P. emarginatus seeds showed toxicity to Artemia salina (LC50 1.63 μg/mL) and was active against all the cell lines tested. The potent cytotoxic activity had IC50 values ranging from 24.9 to 47 μg/mL. However, EO (1-100 µg/mL) had less cytotoxicity in PBMCs isolated from a healthy subject. In summary, the present study showed the potential antiproliferative of the EO of P. emarginatus seeds.

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“…Secondary metabolites such as polyphenols are not required for plant development and growth, but are involved in plant communication and defense [8][9] . Polyphenols interact with pathogens, herbivores, and other plants; they protect from ultraviolet radiation and oxidants, repel or poison predators and attract beneficial insects or microbes [10][11] .…”

Section: Dpph Scavenging Testmentioning

confidence: 99%

Untitled

2011

IJPSR

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The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals were screened for their in vitro antioxidant activity. Stems leaves and root of selected plants were dried at 45°C and powdered for extraction. Extraction was performed with methanol. By employing DPPH (2, 2-diphenyl-1picrylhydrazyl radical) scavenging assays, it was shown that all the ethanol extracts of the samples collected show antioxidant activity. Though, as expected, their potency varied according to the different parts and species. In particular, leaves and stems of Hibiscus esculentus leaves displayed the highest activity. The extracts tested ranged from 0.176 mg/mL -2.45mg/mL. It is generally accepted that a diet rich in plants is associated with a reduced incidence of degenerative diseases, such as atherosclerosis and cancer. This study suggests that the Hibiscus esculentus plant could be pharmaceutically exploited for antioxidant properties.

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Evidence of the involvement of biogenic amines in the antinociceptive effect of a vouacapan extracted from Pterodon polygalaeflorus Benth

Cited by 35 publications

References 14 publications

Oil Glands in Pterodon pubescens Benth. (Leguminosae-Papilionoideae): Distribution, Structure, and Secretion Mechanisms

Oil Glands in Pterodon pubescens Benth. (Leguminosae-Papilionoideae): Distribution, Structure, and Secretion Mechanisms

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

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