Evidence of size-dependent Effect of Silica micro- and nano-particles on Basal and Specialized Monocyte Functions

Marzi, Mauricio C. De; Saraceno, Martín; Mitarotonda, Romina; Todone, Marcos; Fernández, María Elena Márquez; Malchiodi, Emilio L.; Desimone, Martín Federico

doi:10.4155/tde-2017-0053

Cited by 20 publications

(17 citation statements)

References 52 publications

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“…Accordingly, up-regulation of CD86 expression was observed following exposure to surface-modified FeNP, SiO 2 NP, and mixed-metal alloy nanoparticles (Liu, Y et al 2013). de Marzi et al (2017) exposed THP-1 cells to a wide range of SiO 2 particle sizes (10–1430 nm); while all particles promoted activation marker expression, the 240 nm SiO 2 particles induced the greatest degree of CD80 expression. Similar findings were reported by an investigation that assessed the potential for metal debris released from orthopedic implants to trigger immune activation.…”

Section: Effects Of Metal Nanomaterials On Immune Cells and Allergic mentioning

confidence: 99%

“…Similar findings were reported by an investigation that assessed the potential for metal debris released from orthopedic implants to trigger immune activation. Both ~2 mm cobalt-chromium-molybdenum alloy particles and soluble metal ions induced elevations in THP-1 co-stimulatory molecule expression, suggesting that a wide range of metal particle sizes have the capacity to induce immune effects involved in allergic sensitization (Caicedo et al 2010; de Marzi et al 2017). Contrarily, no elevations in THP-1 expression of CD86 or CD54 were observed in response to 100 nm AgNP exposure (Galbiati et al 2018).…”

Section: Effects Of Metal Nanomaterials On Immune Cells and Allergic mentioning

confidence: 99%

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Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/ exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

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Section: Effects Of Metal Nanomaterials On Immune Cells and Allergic mentioning

confidence: 99%

Section: Effects Of Metal Nanomaterials On Immune Cells and Allergic mentioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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“…Se ha reportado una correlación inversa entre el tamaño de algunos tipos de NP y citotoxicidad in vitro [37], [38], [39], [40], [41], [42]. Las NP más pequeñas penetran en las células de los organismos a través de la pinocitosis, mientras que las más grandes por fagocitosis.…”

Section: ____________________________________________________________unclassified

Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Ale

Bacchetta

Rossi

et al. 2018

Ecotoxicology and Environmental Safety

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ACAP: antioxidant capacity againt peroxiles radicals, capacidad antioxidante contra radicales peroxilos ACP: análisis de componentes principales AgNP: nanopartículas de plata AH: ácidos húmicos ALT: alanino-aminotransferasa AST: aspartato-aminotransferasa CAT: catalasa CL 50 : concentración letal 50 CM: células mucosas CMHC: concentración media de hemoglobina corpuscular Col: colesterol DI: distancia interlamelar DML: desestabilización de la membrana lisosomal EDS: energy dispersive spectroscopy, análisis de energía dispersiva EEP: espesor del epitelio basal ELS: espesor de laminillas secundarias FC: factor de condición Gla: glucosa GlB: glóbulos blancos Glo: glucógeno GlR: glóbulos rojos GPx: glutatión peroxidasa GR: glutatión reductasa GSH: glutatión reducido GSSG: glutatión oxidado GST: glutatión S-transferasa Hb: hemoglobina HCM: hemoglobina corpuscular media Ht: hematocrito IHS: índice hepato-somático I org : índice del órgano I pr : índice del patrón de reacción LE: longitud estándar LLS: longitud de laminillas secundarias LPO: lipid peroxidation, peroxidación lipídica LT: longitud total MN: micronúcleos MT: metalotioneínas NM(s): nanomaterial(es) NP(s): nanopartícula(s)

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“…Similar findings were reported by an investigation that assessed the potential for metal debris released from orthopedic implants to trigger immune activation. Both ~ 2 µm cobalt-chromium-molybdenum alloy particles and soluble metal ions induced elevations in THP-1 co-stimulatory molecule expression, suggesting that a wide range of metal particle sizes have the capacity to induce immune effects involved in allergic sensitization (497,1036). Contrarily, no elevations in THP-1 expression of CD86 or CD54 were observed following exposure to 100 nm AgNP or 5/50 nm PtNP in vitro (1037,1038).…”

Section: Metal Nanomaterials Effects On DC and Sensitization In Vitromentioning

confidence: 96%

“…Many metal nanomaterials have been shown to induce dose-dependent cytotoxic effects on monocytes resulting in apoptotic, autophagic, or necrotic cell death (1203)(1204)(1205). Several studies have correlated cytotoxic potential of ZnONP, NiONP, SiO2NP, AlNP, and AgNP to decreasing size (1036,1057,1178,1196,1206,1207). Furthermore, AuNP corona formation, ZnONP charge and surface coating, and AgNP dissolution potential have been implicated in cytotoxic effects on monocytes (523,1039,1058,1206).…”

Section: Metal Nanomaterials Effects On Other Immune Cells In Vitromentioning

confidence: 99%

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

Roach¹

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The recent surge in incorporation of engineered metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings has raised concerns over their potential to induce material size-specific toxicological effects. Although metal nanomaterials have been shown to induce greater degrees of lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy.Overall, more scientific knowledge exists regarding the potential for metal-containing nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Despite the existence of such knowledge, specific correlations between metal nanomaterial physico-chemical properties and their allergic effects have yet to be consistently demonstrated. As the number of emerging nanomaterials continues to increase, the delineation of these relationships has the potential to advance risk assessment efforts by helping to identify specific agents that may present an elevated risk for allergic effects.Two sets of studies were designed to begin addressing some of the knowledge gaps associated with the immunotoxic potential of metal nanomaterials in the context of allergic disease. The hypothesis of these studies was that nanomaterials comprised of metal constituents with known immunomodulatory potential augment, induce, and elicit allergic disease more readily than larger forms of the materials. Moreover, the nature of the immune responses caused by exposure to these metal nanomaterials, as well as the magnitude of the effects, correlates best with the parameter of dose surface area.The first set of studies incorporated NiO particles with different physico-chemical properties into an in vivo time course study and OVA asthma model. Results from the time course study demonstrated that the smaller NiO particles caused more pronounced pulmonary injury and inflammation, a discrepancy that could be mitigated by normalizing the administered particle dose to the surface area of the larger material. In the OVA model, augmentation of the allergic response was largely conserved with respect to NiO surface area, wherein larger doses caused polarization of pulmonary immune reposes towards a Th1/17-dominant state and smaller doses induced Th2-skewed responses. Despite this association, several immune markers, including total IgE production, BAL eosinophil number, and Penh response correlated better with other metrics, such as particle size.The second set of studies employed Au particles and nanoparticles to assess size-specific differences in allergenic potential. Neither particle was associated with potential for skin...

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Evidence of size-dependent Effect of Silica micro- and nano-particles on Basal and Specialized Monocyte Functions

Abstract: Cell activation properties of silica particles could be useful tools for immune stimulation therapy, while 10 nm NPs would be suitable for molecule transportation.

Cited by 20 publications

References 52 publications

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

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