Evidence of Significant Ceftriaxone and Quinolone Resistance in Cirrhotics with Spontaneous Bacterial Peritonitis

Ardolino, Eric; Wang, Susan S; Patwardhan, Vilas

doi:10.1007/s10620-019-05519-4

Cited by 19 publications

(18 citation statements)

References 23 publications

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“…To the Editor: We read with immense interest the article entitled "Prevalence and Predictors of Third-Generation Cephalosporin Resistance in the Empirical Treatment of Spontaneous Bacterial Peritonitis" by Sunjaya et al 1 Notably, the rate of third-generation cephalosporin resistance in the authors' study cohort was only 10% despite reported higher resistance rates in the recent literature from the United States, Europe, and China. [2][3][4][5] A recent study we conducted at our university hospital revealed similarly higher thirdgeneration cephalosporin resistance rate (36.1%). In our study, we defined culture-positive spontaneous bacterial peritonitis (SBP) as the presence of a polymorphonuclear neutrophil (PMN) count greater than 250 /mL in ascites, growth of one bacterial species within 5 days of ascitic fluid collection, and no identifiable source of intra-abdominal infection.…”

Section: Increasing Resistance To Third-generation Cephalosporins In Spontaneous Bacterial Peritonitismentioning

confidence: 71%

Increasing Resistance to Third-Generation Cephalosporins in Spontaneous Bacterial Peritonitis

Tripathi

Koirala

Kato

2020

Mayo Clinic Proceedings

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Section: Increasing Resistance To Third-generation Cephalosporins In Spontaneous Bacterial Peritonitismentioning

confidence: 71%

Increasing Resistance to Third-Generation Cephalosporins in Spontaneous Bacterial Peritonitis

Tripathi

Koirala

Kato

2020

Mayo Clinic Proceedings

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“…BioMed Research International resistance rate was 8% in community-acquired infections and 41% in hospital-acquired infections ( Table 1). Ardolino et al [39] retrospectively studied 160 SBP cases in the United States from 2005 to 2015. This study reports that gram-negative bacteria were mainly E. coli.…”

Section: Epidemiologymentioning

confidence: 99%

“…Ardolino et al [ 39 ] retrospectively studied 160 SBP cases in the United States from 2005 to 2015. This study reports that gram-negative bacteria were mainly E. coli .…”

Section: Epidemiologymentioning

confidence: 99%

Current Status and Prospects of Spontaneous Peritonitis in Patients with Cirrhosis

Huang

Peng

2020

BioMed Research International

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Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient’s condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences pathogenic bacteria distribution; therefore, different hospitals in the same country record different bacteria strains. Intestinal changes and a weak immune system in patients with liver cirrhosis lead to bacterial translocation thus causing SBP. Early diagnosis and timely treatment are important in SBP management. When the treatment effect is not effective, other rare pathogens should be explored.

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“…[4][5][6][7] Poor antimicrobial coverage with cephalosporins has also been reported earlier, but in the range of 10%-45%. [8][9][10][11] As ours is a tertiary care referral centre, it is possible that patients may have been partially treated elsewhere previously. Nonetheless, vancomycin resistant Enterococci were fewer than in a German study, 12 and we did not see Vancomycin resistance in Staphylococci as in a Chinese study.…”

Section: Mittal Et Almentioning

confidence: 99%

Microbiological profile of pathogens in spontaneous bacterial peritonitis secondary to liver cirrhosis: a retrospective study

2020

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Spontaneous bacterial peritonitis (SBP) is an acute bacterial infection of ascitic fluid without an obvious source. The prevalence of SBP in patients with cirrhosis is in the range of 10%–30%. With increasing use of antibiotics, there is a gradual shift in the causative flora of SBP from Gram-negative bacteria to Gram-positive and, more importantly, to drug-resistant bacteria. The aim of this retrospective study on 721 cases was to identify the prevalence of various organisms causing SBP along with their drug sensitivity and resistance patterns. A prevalence of 38.2% culture positivity was observed in our South Indian population. Escherichia coli was the most common pathogen isolated. Third-generation cephalosporins showed high rates of resistance, but a susceptibility of 74.5% to amikacin was found. Nonetheless, 42% of culture-positive isolates exhibited multidrug resistance, the highest rates being seen with Enterococcus faecium (64.2%) and Acinetobacter baumannii (71.4%).

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Evidence of Significant Ceftriaxone and Quinolone Resistance in Cirrhotics with Spontaneous Bacterial Peritonitis

Cited by 19 publications

References 23 publications

Increasing Resistance to Third-Generation Cephalosporins in Spontaneous Bacterial Peritonitis

Increasing Resistance to Third-Generation Cephalosporins in Spontaneous Bacterial Peritonitis

Current Status and Prospects of Spontaneous Peritonitis in Patients with Cirrhosis

Microbiological profile of pathogens in spontaneous bacterial peritonitis secondary to liver cirrhosis: a retrospective study

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