Evidence of Nonadherence in Cases of Pseudoresistant Hypertension

Zanatta, João Marcos de Menezes; Cosenso-Martin, Luciana Neves; Lopes, Valquiria da Silva; Uyemura, Jéssica Rodrigues Roma; Santos, Aleandra Marton Polegati; Landim, Manoel Ildefonso Paz; Vilela-Martin, José Fernando

doi:10.2147/ibpc.s264057

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…Moreover, causes of secondary hypertension were also excluded. 19 Therefore, we decided to offer patients a new therapeutic option, which may reduce sympathetic modulation, increase vagal modulation, and decrease blood pressure in RH individuals.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral and Central Hemodynamic Parameters on Resistant Hypertension: A Case Report

Giollo-Junior¹,

Cosenso-Martin²,

Lopes³

et al. 2023

VHRM

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Resistant hypertension (RH) is characterized by being difficult to control, even with the use of various antihypertensive drugs and is associated with target organ lesions and other comorbidities. Thus, new treatment alternatives such as transcutaneous electrical nerve stimulation (TENS) can offer benefits to resistant hypertensive patients by reducing blood pressure (BP) in a non-invasive way and without the need for the association of more antihypertensive drugs. In this case, a patient with RH was submitted to three weekly applications of TENS on the stellate ganglion lasting 40 min each for 1 month. Peripheral and central hemodynamic assessments were performed by 24-h ambulatory BP monitoring (ABPM) before and after TENS applications. After completion of the TENS applications, significant reductions in office systolic (SBP) and diastolic BP (DBP) were observed. There was also a decrease in peripheral SBP and DBP in the 24‐h ABPM and sleep and SBP during wakefulness. Additionally, central parameters including central SBP and pulse wave velocity presented a significant reduction in the 24‐h ABPM, during the wakefulness and sleep. TENS is able to attenuate the sympathetic hyperactivity present in RH cases and decrease the peripheral and central hemodynamic parameters of a resistant hypertensive patient.

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Section: Discussionmentioning

confidence: 99%

The Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral and Central Hemodynamic Parameters on Resistant Hypertension: A Case Report

Giollo-Junior¹,

Cosenso-Martin²,

Lopes³

et al. 2023

VHRM

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“…Undiagnosed hypertension also poses a significant challenge, particularly in rural areas, underscoring the importance of accurate measurement and awareness initiatives. [5][6][7][8] This trend underscores the urgent need for effective hypertension management strategies in India and similar contexts.…”

Section: Section 1 -Introductionmentioning

confidence: 99%

InSH Consensus Guideline for the Management of Hypertension, 2023

Gupta,

Maheshwari,

Verma

et al. 2023

htnj

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“…Before resistant hypertension is diagnosed, pseudo-resistance hypertension should be ruled out. Pseudo-resistance hypertension could be due to error in blood pressure measurement, white coat effect and medication nonadherence 8,9 . White coat resistant hypertension might be responsible for about one-third of the classically defined resistant hypertensive patients 10 .…”

Section: Introductionmentioning

confidence: 99%

Resistant hypertension

Moke

Ekuerhare

Enaohwo

et al. 2022

J. Drug Delivery Ther.

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Background: Resistant hypertension is a common medical challenge facing clinicians and specialists. Although, the prevalence is currently unknown but various clinical trials have suggested that this problem is not rare. Resistant hypertension is blood pressure that remains above goal despite the use of at least three antihypertensive agents including a diuretic. It is a subtype of hypertension that increases the risk of cardiovascular, cerebrovascular and kidney disease. However, it is important to distinguish between pseudo-resistant hypertension and apparent hypertension from true resistant hypertension as they are often misdiagnosed. Objectives: This review focuses on resistant hypertension, its pathophysiology and established therapy. Methodology: Relevant articles used for this review covered a period of 2008-2022 using search engines and databases including PubMed, Scopus, Web of Science, and Google Scholar. Main observation: Evaluation of patients with true resistant hypertension includes appropriate blood pressure measurement, screening for causes of secondary hypertension and screening for interfering medications. Management of resistant hypertension that has proved successful includes non-pharmacological approach like lifestyle modification and optimization of pharmacological agents, often including the use of mineralocorticoid receptor antagonist. Conclusion: Considering the future management of resistant hypertension, a bunch of new device-based therapies are under effective development. Of these, renal denervation and carotid baroreflex activation are two potential devices for the significant reduction of blood pressure. However, further study is necessary before these devices can be approved for the routine treatment of resistant hypertension. Keywords: Aldosterone; Cardiovascular disease; Resistant Hypertension; Therapy.

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Evidence of Nonadherence in Cases of Pseudoresistant Hypertension

Cited by 3 publications

References 40 publications

The Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral and Central Hemodynamic Parameters on Resistant Hypertension: A Case Report

The Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral and Central Hemodynamic Parameters on Resistant Hypertension: A Case Report

InSH Consensus Guideline for the Management of Hypertension, 2023

Resistant hypertension

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