Evidence of nitrosative stress within hearts of patients dying of Tako-tsubo cardiomyopathy

Surikow, Sven Y; Raman, Betty; Licari, J.; Singh, Kuljit; Nguyen, Thanh Ha; Horowitz, John D.

doi:10.1016/j.ijcard.2015.03.416

Cited by 28 publications

(22 citation statements)

References 10 publications

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“…Indeed, TTS patients have markers of increased NO signalling 109 and post-mortem hearts of TTS patients also demonstrate markers of increased nitrosative stress. 110 Peroxynitrite release would also result in activation of poly(ADP-ribose)-transferase-1, which might contribute to the myocardial energetic impairment, which has recently been reported in patients with TTS. 111 Endomyocardial biopsies in patients with TTS further suggest that these anti-apoptotic pathways are activated acutely.…”

Section: Pathophysiologymentioning

confidence: 94%

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Ghadri

Wittstein

Prasad

et al. 2018

European Heart Journal

1,135

1,284

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Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

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Section: Pathophysiologymentioning

confidence: 94%

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Ghadri

Wittstein

Prasad

et al. 2018

European Heart Journal

1,135

1,284

View full text Add to dashboard Cite

show abstract

“…Similarly to oxidative damage, nitrosative damage – that caused by reactive nitrogen species (RNS), such as nitric oxide – has been suggested to also contribute to age-related diseases, namely, hepatic steatosis and apoptosis (Abdelmegeed et al, 2016), as well as functional and structural changes in the cardiovascular system (Novella et al, 2013; Surikow et al, 2015). Additionally, it has also been associated to impairments in sleep homeostasis (Rytkönen et al, 2010), psychological disorders (Maurya et al, 2016) and dementia (Mangialasche et al, 2009).…”

Section: Theories Of Aging and How They Shape The Definitions Of Smentioning

confidence: 99%

A synopsis on aging—Theories, mechanisms and future prospects

Costa

Vitorino

Silva³

et al. 2016

Ageing Research Reviews

329

170

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Answering the question as to why we age is tantamount to answering the question of what is life itself. There are countless theories as to why and how we age, but, until recently, the very definition of aging – senescence – was still uncertain. Here, we summarize the main views of the different models of senescence, with a special emphasis on the biochemical processes that accompany aging. Though inherently complex, aging is characterized by numerous changes that take place at different levels of the biological hierarchy. We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. From this multi-dimensional approach, it becomes clear that an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why we age, is necessary.

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“…The recent findings of increased generation of peroxynitrite (ONOO−) and down stream activation of activation of poly (ADP-ribose) polymerase 1 (PARP-1) in the human myocardium of patients dying of TTS may hint towards another possible therapeutic target to improve energetic impairment. 57 In conclusion, we have now realized that TTS is a rather complicated disorder and not as simple as once thought. Evidence regarding treatment of TTS and its related complications comes from registry data and observational studies.…”

Section: Future Directions -Possible Targets For Interventionmentioning

confidence: 66%

Takotsubo Syndrome Therapy: Current Status and Future Directions

Singh¹,

Akashi²,

Horowitz³

2016

ICFJ

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<p>Tako-Tsubo Cardiomyopathy (TTC), which is now known as Tako-Tsubo Syndrome (TTS) is a transient left ventricular (LV) systolic dysfunction of uncertain pathogenesis, which occurs predominantly in ageing women. There is considerable uncertainty regarding the management of TTS related acute and chronic issues and most of the evidence regarding therapy comes from retrospective data and case studies. In this review we have tried to concise the available information on the TTS therapeutics to help clinicians make treatment decisions in patients diagnosed with TTS. At the same time we have highlighted some of the uncertainties regarding TTS therapy, in particular the inability of b-blocker therapy to improve survival or prevent recurrence. We have also emphasized the issue of incomplete recovery in some cases of TTS where there is ongoing inflammation and evidence of impaired myocardial energetics despite normalization of LV ejection fraction. Although there is no scientific evidence on how to improve or fasten the recovery of TTS, we believe therapy improving energy efficiency may play some role in future. Lastly, we would like to reiterate that in the absence of randomized studies evaluating medical therapy in TTS, the treatment for this syndrome remains entirely empirical and should be individualized according to the patient characteristics at the time of presentation.</p>

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Evidence of nitrosative stress within hearts of patients dying of Tako-tsubo cardiomyopathy

Cited by 28 publications

References 10 publications

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

A synopsis on aging—Theories, mechanisms and future prospects

Takotsubo Syndrome Therapy: Current Status and Future Directions

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