Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms

Egashira, Kensuke; Inou, Tetsuzi; Hirooka, Yoshitaka; Yamada, Akira; Urabe, Yoshitoshi; Takeshita, Akira

doi:10.1056/nejm199306103282302

Cited by 520 publications

(225 citation statements)

References 32 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…Many studies have demonstrated a prominent role of vascular health in normal systemic physiology [1][2][3] . However, age 4 , cardiovascular risk factors 5 , and cardiovascular disease 6 adversely affect vascular health.…”

Section: Introductionmentioning

confidence: 99%

Vascular health and cognitive function in older adults with cardiovascular disease

Forman¹,

Cohen²,

Hoth³

et al. 2008

ARTRES

View full text Add to dashboard Cite

Background-We hypothesized that changes in vascular flow dynamics resulting from age and cardiovascular disease (CVD) would correlate to neurocognitive capacities, even in adults screened to exclude dementia and neurological disease. We studied endothelial-dependent as well as endothelial-independent brachial responses in older adults with CVD to study the associations of vascular responses with cognition. Comprehensive neurocognitive testing was used to discern which specific cognitive domain(s) correlated to the vascular responses.

show abstract

Section: Introductionmentioning

confidence: 99%

Vascular health and cognitive function in older adults with cardiovascular disease

Forman¹,

Cohen²,

Hoth³

et al. 2008

ARTRES

View full text Add to dashboard Cite

show abstract

“…6) Although ED has been associated with the presence of atherosclerosis, impaired endothelial-dependent NO bioactivity has also been shown in patients with atherosclerosis risk factors without overt vascular disease. [7][8][9][10][11] It has also been shown that NO is essential for flow-mediated dilatation of large human arteries in vivo. 12) Therefore, the purpose of this study was to measure plasma NO levels in patients with SCF and to compare them with normal coronary flow (NCF).…”

mentioning

confidence: 99%

Plasma Nitric Oxide Level and Its Role in Slow Coronary Flow Phenomenon

et al. 2005

View full text Add to dashboard Cite

SUMMARYPrevious studies have suggested that microvascular abnormalities and endothelial dysfunction cause slow coronary flow (SCF). The objective of this study was to assess the plasma nitric oxide (NO) level and determine its role in the pathogenesis of SCF phenomenon. Thirty-six patients with SCF (group 1) and otherwise patent coronary arteries and 34 subjects with normal coronary flow (group 2) were included in the study. Coronary flow was quantified according to the TIMI Frame Count (TFC) method. Brachial artery endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerin (NTG)-induced endothelium-independent dilatation were studied in both groups. In addition, plasma NO levels were measured and their contribution to FMD was determined. The sex, age, body mass index, arterial blood pressure, and heart rate distributions were similar in both groups. TFC was significantly higher in group 1 compared to group 2 for each artery. The plasma NO level was lower in patients with SCF than in control subjects (18.4 ± 4.4 versus 25.2 ± 6.3 µmol/L P = 0.001). FMD was significantly smaller in group 1 than in group 2 (4.0 ± 3.2% versus 10.6 ± 5.8%, P = 0.0001). The percent NTG-induced dilatation was similar in the two groups (16.8 ± 1.1% versus 17.1 ± 1.1%, P = 0.42). In group 1, the plasma NO level was correlated with percent of FMD. Also, the plasma NO level was inversely correlated with TFC for each artery. Reduced NO bioactivity as well as impaired FMD support the presence of endothelial damage in the pathogenesis of SCF phenomenon. (Int Heart J 2005; 46: 373-382)

show abstract

“…There are no documented values for increase in coronary flow velocity after NTG administration in healthy children, but our results are comparable to values obtained in healthy adults. 24,25 …”

Section: Discussionmentioning

confidence: 99%

Normal Coronary Flow Reserve After Arterial Switch Operation for Transposition of the Great Arteries

et al. 2002

View full text Add to dashboard Cite

Background-Recent studies performed with positron emission tomography have suggested that coronary flow reserve (CFR) is moderately to severely reduced after the arterial switch operation (ASO). These findings are of great concern but have not been confirmed by other methods. Methods and Results-Eleven symptom-free children were studied between 4 and 11 (median 6.0) years after the ASO.Flow velocity in the left anterior descending (LAD) and right coronary arteries (RCA) was measured with a 0.014-inch Doppler FloWire (Cardiometrics) before and after intracoronary injection of adenosine (0.5 g/kg) and nitroglycerin (5 g/kg). CFR was defined as the ratio of hyperemic to basal average peak velocity (APV). The median (range) CFR in the LAD was 3.7 (3.0 to 4.8) and 3.4 (2.9 to 4.8) in the RCA. The increase in APV after intracoronary injection of nitroglycerin was 300% (240% to 420%) in the LAD and 260% (190% to 460%)

show abstract

Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms

Abstract: These findings suggest that endothelium-dependent dilatation of the resistance coronary arteries is defective in patients with anginal chest pain and normal coronary arteries, which may contribute to the altered regulation of myocardial perfusion in these patients.

Cited by 520 publications

References 32 publications

Vascular health and cognitive function in older adults with cardiovascular disease

Vascular health and cognitive function in older adults with cardiovascular disease

Plasma Nitric Oxide Level and Its Role in Slow Coronary Flow Phenomenon

Normal Coronary Flow Reserve After Arterial Switch Operation for Transposition of the Great Arteries

Contact Info

Product

Resources

About