Evidence of human bocavirus viremia in healthy blood donors

Bonvicini, Francesca; Manaresi, Elisabetta; Gentilomi, Giovanna Angela; Furio, Francesca Di; Zerbini, Marialuisa; Musiani, Monica; Gallinella, Giorgio

doi:10.1016/j.diagmicrobio.2011.08.019

Cited by 28 publications

(25 citation statements)

References 19 publications

(25 reference statements)

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“…There has been little research on HBoV in blood and plasma donors. Recently, Italian healthy blood donors were screened for HBoV, with a prevalence of 5.51% and a load ranging from 1.79 × 10 2 to 3.33 × 10 3 copies/mL . Our study indicated the genomic prevalence of HBoV DNA in healthy Chinese plasma donors was 9.06% (552/6096), with HBoV DNA titers ranging from 5.01 × 10 2 to 3.02 × 10 6 copies/mL, which were higher than those of Italian blood donors both in the prevalence and in the viral contents.…”

Section: Discussionmentioning

confidence: 67%

“…However, HBoV DNA is not restricted to the respiratory or digestive tracts; it has also been identified in acute-and convalescent-phase serum from children with acute respiratory tract infections, with viral loads in some cases higher than 10 4 copies/ mL. 5,6,13,[20][21][22][23] Another study detected HBoV DNA in healthy blood donors, 14 albeit at low levels, suggesting the possibility that the virus could be transmitted by blood transfusion and could pose a threat to blood safety.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is limited information about the prevalence of HBoV in blood. Recently, Bonvicini and coworkers tested the prevalence of HBoV DNA in serum samples from healthy blood donors, and low virus loads and prevalence of the HBoV genome were indicated.…”

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confidence: 99%

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The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives

Zeng

et al. 2014

Transfusion

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives

Zeng

et al. 2014

Transfusion

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“…Interestingly, they found significant differences between the BK and JC viruses with respect to virus-host interaction and epidemiology. Moreover, lymphotropic Polyomavirus and human Bocavirus (HBoV) have also been frequently found in the peripheral blood of immunocompromised and apparently healthy subjects [64,65]. …”

Section: Exploring the Viral Flora In Humansmentioning

confidence: 99%

Describing the Silent Human Virome with an Emphasis on Giant Viruses

et al. 2013

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Viruses are the most abundant obligate intracellular entities in our body. Until recently, they were only considered to be pathogens that caused a broad array of pathologies, ranging from mild disease to deaths in the most severe cases. However, recent advances in unbiased mass sequencing techniques as well as increasing epidemiological evidence have indicated that the human body is home to diverse viral species under non-pathological conditions. Despite these studies, the description of the presumably healthy viral flora, i.e. the normal human virome, is still in its infancy regarding viral composition and dynamics. This review summarizes our current knowledge of the human virome under non-pathological conditions.

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“…Should the virus be able to persist in an episomal form, this, in addition to simultaneous acute coinfection, could be a further explanation for the frequent detection of HBoV as a copathogen in airway infections, if HBoV-positive cells are present in the clinical material without high-level replication. Moreover, this gives rise to the hypothesis that HBoV could also persist in the infected host and acquires an asymptomatic but productive state, which in turn could explain the relatively high percentage of virus shedding patients without symptoms [54].…”

Section: Introductionmentioning

confidence: 99%

Human bocavirus

Schildgen

Khalfaoui

Schildgen

2014

Reviews in Medical Microbiology

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The human bocavirus (HBoV) was initially discovered in 2005 in clinical samples from the respiratory tract of children suffering from respiratory infections of unknown aetiology and would be the second parvovirus that is capable of infecting humans with the potential to cause clinical diseases. HBoV-1 is detected as the fourth most common virus in respiratory infections and is associated with respiratory symptoms and sometimes also gastroenteritis in virtually all age groups [1,2]. Having been shown to form covalently closed circular DNA it appears likely that HBoV has the ability to persist in the infected tissue as other parvoviruses do [3][4][5][6][7], maybe leading to a chronic inflammation on the edge of its detection limit. Consequently HBoV could be detected in chronic lung diseases and, moreover, in tumour tissue of the lung and of the gastrointestinal tract. Therefore, it remains unclear to what extent the virus contributes to the development of such cancers or if the virus infects tumour cells preferentially. In this review we summarize our current knowledge about HBoV and discuss the perspective and challenges of future HBoV research. ß

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Evidence of human bocavirus viremia in healthy blood donors

Cited by 28 publications

References 19 publications

The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives

The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives

Describing the Silent Human Virome with an Emphasis on Giant Viruses

Human bocavirus

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