Evidence of gene-controlled sterility in bulls

Donald, H. P.; Hancock, J. L.

doi:10.1017/s0021859600044944

Cited by 56 publications

(26 citation statements)

References 10 publications

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“…However, in the majority of reported cases the mode of inheritance is not clear because of the small numbers of animals or relatives of the affected animals which had been investigated. Donald & Hancock (1953) found the knobbed acrosomal defect in seventeen sterile Fresian bulls. These bulls were related, and the authors suggested that the condition was the result of a single autosomal recessive gene which has no effect on the females.…”

Section: Discussionmentioning

confidence: 99%

“…A 'knobbed' acrosomal defect has been described in the spermatozoa of bulls by Hancock (1953) and Blom & Birch-Andersen (1962) and in the spermatozoa from boars (Bane, 1961). An abnormality of the spermatozoa from some Guernsey bulls known as the 'decapitate defect' in which the head and tail become separated was shown to be associated with an ultrastructural abnormality in the neck region (Blom & Birch-Andersen, 1970).…”

Section: Introductionmentioning

confidence: 99%

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Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Ross¹,

Christie²,

Edmond³

1973

Reproduction

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Similar ultrastructural defects were found in the spermatozoa of two oligospermic men attending a subfertility clinic. The majority of spermatozoa had a mid-piece of grossly abnormal morphology and the diameter of the tail was increased, due to an excess of outer-sheath fibres. Extra, as well as missing, axial-filament fibres were also seen. In both cases, only a very small proportion of the spermatozoa were motile.A testicular biopsy was performed on each man and although the histological appearance was normal, abnormal spermatozoa were seen in thin sections examined by electron microscopy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Ross¹,

Christie²,

Edmond³

1973

Reproduction

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“…However, a common sensitivity to local conditions or to a n environmental agent may have led to expression of this lesion and recovery within the same time frame. Hereditary considerations apparently play a role in the expression of other sperm cell head defects, demonstrated most notably in the case of the knobbed acrosome defect in the bull (Donald and Hancock, 1953;Blom and Birch-Andersen, 1962) and the SME defect in the boar (Blom and Jensen, 1977).…”

Section: Discussionmentioning

confidence: 99%

Diadem/crater defects in spermatozoa from two related angus bulls

Larsen

Chenoweth

1990

Molecular Reproduction Devel

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The diadem/crater defect was studied over several months in two related 20-month-old Angus bulls. In bull 1, diadem/crater defects were present in 2-99% of ejaculated spermatozoa at various times during the evaluation period. In bull 2, affected cells varied from 20% to 94%, with other abnormalities (head and acrosome defects, coiled tails, proximal cytoplasmic droplets) also common. Single sire mating trials conducted over 26 days during an apparent recovery phase showed normal fertility (approximately 50% pregnancies per estrus exposed). Both resting and gonadotropin-releasing hormone (GnRH)-stimulated testosterone values were within nor-mal limits. Histopathological evaluation of testes showed no obvious hypoplastic, inflammatory, or degenerative condition. Electron microscopy of ejaculated spermatozoa demonstrated the characteristic diadem pattern of craters in the equatorial region of the head. Many cells from bull 2 contained large craters in other regions of the nucleus. Electron microscopy of testicular tissue demonstrated nuclear invaginations lined by a single unit membrane in round spermatids. Lesions in elongated spermatids were more pronounced, with curling of the nucleus and large membrane-filled cavities in the chromatin occurring in addition to craters in the equatorial region of the nucleus.

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“…Abnormal sperm morphology could not account for these findings. In Friesian bulls, abnormal development of acrosomes resulting in so-called "knobbed" sperm was implicated in sterility resulting from an autosomal sex-limited recessive gene influenced by local environmental conditions within the testes (41). A greater proportion of abnormal embryos might result from insemination in vitro than in vivo under conditions involving genetic aberrations and following cytogenetic evaluation insights to mechanisms of genetic toxicity, i.e., infertility, might be forthcoming.…”

Section: Uses and Potential Uses Of In Vitro Fertilizationmentioning

confidence: 99%

In vitro fertilization: a potential means for toxicity testing

Brackett¹

1978

Environ Health Perspect

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Uses and potential uses of in vitro fertilization are: (1) a research tool for investigating biochemistry of fertilization, (2) an assay for fertilizing ability, (3) a potentially useful clinical approach for certain cases of infertility, and (4) a potentially useful means for improving animal breeding. In vitro fertilization methodology is sufficiently advanced for gametes of several mammalian species, especially mouse, rabbit, and rat, for use in evaluating effects imposed by toxic agents of environmental or genetic origin. Alteration of the normal events of fertilization and/or embryonic development following transfer of in vitro fertilized embryos into surrogate dams can serve as end point(s) in applying this means for toxicity testing. In vitro fertilization of mouse and rat ova has been explored as an alternative to in vivo fertilization in male contraceptive development studies. Original observations on toxicity of abnormal 02 concentrations for rabbit fertilization in vitro are reported here. Ova were fertilized under 0, 20, 48, and 95% 02, but toxicity from the extreme conditions, 0 and 95% was apparent from comparison of proportions of fertilized ova reaching the 4-cell stage during the 24-hr incubation. Toxicity was further evidenced by inability of embryos fertilized under 0 and 95%02 tensions, in contrast to those fertilized under 20% 02, to sustain normal gestation following their transfer into recipient does. Recent success in the fertilization of cow ova in vitro in this laboratory provides encouragement to develop a useful means for testing normalcy of gametes in this species. Such studies might lead to useful screening procedures for avoidance of human infertility resulting from hazardous environmental conditions.

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Evidence of gene-controlled sterility in bulls

Abstract: A study has been made of the relationships of sterile Friesian bulls manifesting ‘knobbed’ spermatozoa, and the conclusion drawn that the characteristic defect of the acrosome is due to an autosomal sexlimited recessive gene (kn).

Cited by 56 publications

References 10 publications

Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Ultrastructural Tail Defects in the Spermatozoa From Two Men Attending a Subfertility Clinic

Diadem/crater defects in spermatozoa from two related angus bulls

In vitro fertilization: a potential means for toxicity testing

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