Evidence of Epstein-Barr virus infection in ulcerative colitis

Bertalot, Giovanni; Villanacci, Vincenzo; Gramegna, M.; Orvieto, E.; Negrini, Riccardo; Saleri, A; Terraroli, C.; Ravelli, P.; Cestari, Renzo; Viale, Giuseppe

doi:10.1016/s1590-8658(01)80106-7

Cited by 35 publications

(36 citation statements)

References 29 publications

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“…Latently and productively EBV-infected B cells are present at a higher frequency in the colonic mucosa of patients with ulcerative colitis than controls [67,68]. Patients with Crohn's disease also have a higher frequency of EBV-infected B cells in the colonic mucosa than controls [67].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 97%

Epstein-Barr Virus and Autoimmunity

Pender

2004

Infection and Autoimmunity

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Section: Inflammatory Bowel Diseasementioning

confidence: 97%

Epstein-Barr Virus and Autoimmunity

Pender

2004

Infection and Autoimmunity

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“…11 EBV has also been observed in large bowel mucosal samples from infl ammatory bowel disease (IBD) patients, 12 and evidence of EBV infection in the mucosal infl ammatory cells of UC has been considered to suggest a possible role of this virus in the chronicity of UC. 13 In this article, we report a case of primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory UC. To our knowledge, this is the fi rst reported case of NK/T-cell colonic lymphoma that developed in a patient with refractory UC.…”

Section: Introductionmentioning

confidence: 97%

Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis

et al. 2008

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A case of primary NK/T-cell lymphoma of the rectum accompanied with ulcerative colitis (UC) in a 73-year-old man is reported. He had a 6-year history of repeated admission to our hospital for UC. Total colonoscopy performed 4 months after resolution of refractory UC complicated by cytomegalovirus colitis showed a markedly submucosal tumor in the rectum, which was histologically diagnosed as malignant lymphoma. The findings of computed tomography of the chest and abdomen, gallium scintigraphy, abdominal ultrasonography, and upper gastrointestinal endoscopy showed no abnormal lesions. Therefore, based on a diagnosis of localized rectal lymphoma with UC, proctocolectomy was performed. The resected specimen showed three submucosal tumors in the rectum with local nodal involvement. Histologically, the tumors were characterized by diffusely infiltrating sheets of large atypical lymphoid cells, which were negative for CD4, CD8, and CD20 but were positive for CD56, CD3, and granzyme B. The presence of Epstein-Barr virus (EBV) infection in neoplastic cells was shown by in situ hybridization for EBV-encoded early small RNA1 (EBER-1). Based on these findings, the patient was diagnosed with primary CD56+ NK/T-cell lymphoma of the rectum (stage IIE). This is the first case report of primary rectal NK/T-cell lymphoma accompanied with UC.

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“…The relevance for such a model can be found in patients who experience gammaherpesvirus-exacerbated diseases whose etiology is bacterial, including periodontal diseases [7][8][9] and inflammatory bowel diseases [16][17][18][19][20][21][22]. While it is clear from these studies in patients that gammaherpesviruses, like EBV, have been associated with exacerbated inflammation, it is not altogether clear how such a ubiquitous viral infection can contribute to disease severity.…”

Section: Discussionmentioning

confidence: 99%

“…In several studies, investigators have concluded that co-infection with EBV correlates with the presence or severity of inflammatory bowel disease in some patients [16][17][18][19][20][21][22]. Clearly EBV infection does not cause colitis, however, the presence of EBV in intestinal lesions, and increases in EBVspecific antibodies, have led some investigators to suggest that one environmental factor that could be responsible for exacerbating this inflammatory disease might be co-infection with this virus.…”

Section: Introductionmentioning

confidence: 99%