Evidence of endogenous volatile organic compounds as biomarkers of diseases in alveolar breath

Sarbach, C.; Stevens, P. T.; Whiting, Joshua J.; Puget, Pierre; Humbert, Marc; Cohen‐Kaminsky, Sylvia; Postaire, E.

doi:10.1016/j.pharma.2013.05.002

Cited by 21 publications

(12 citation statements)

References 46 publications

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“…The resulting radical is conjugated, peroxidized by oxygen, and undergoes further chemical reactions. The generation of ROS is described as the destructive aspect of oxidative stress [41]. In oxidative stress, cells are damaged as a result of a chemical reaction with oxidative agents (e.g., the superoxide anion or hydroxyl radical) [6, 42].…”

Section: Origin and Biochemical Pathways Of Major Vocs In Human Exhalmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

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Section: Origin and Biochemical Pathways Of Major Vocs In Human Exhalmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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“…Efforts must continue towards development of less invasive, more standardised and reliable methods, contributing to earlier and more accurate diagnosis of fungal infections, which will lead to more appropriate therapeutic decisions and improved outcomes of at-risk patients. 89 In the meantime, combination of information provided by different markers, or combination of distinct technologies, seems to be the best option for improving diagnostic accuracy.…”

Section: Microbiological Diagnosismentioning

confidence: 99%

Cryptococcus and Cryptococcosis in Cuba. A minireview

Illnait-Zaragozí

Martínez-Machín

Fernández-Andreu

et al. 2014

Mycoses

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Cryptococcosis has emerged as an important public health problem in Africa, Asia and the Americas due to the increasing numbers of persons at risk of this infection and the adaptation of its aetiological agents to new environments. The proper management requires early recognition of Cryptococcus neoformans/C. gattii species complex infection, familiarity with the use and limitations of diagnostic tests and knowledge of the available treatment options. This review will address these issues with the goal of providing sufficient information to suspect, diagnose and treat patients with cryptococcosis based on Cuban data and review of the literature.

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“…Former studies demonstrated that volatile metabolites found in fungi cultures, such as A. fumigates, are detectable in the breath of patients colonized or infected by fungi [71, 72]. As of yet, little scientific attention has been focused on the diagnostic potential of VOCs produced by microorganisms, although these microorganisms are widely used in nature for communication and as chemo-attractants by plants and insects; however, the smell of bacteria has been well documented by human observers.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus species in indoor environments and their possible occupational and public health hazards

et al. 2016

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The genus Aspergillus, which consists of a few hundred opportunistic mold species found in various climatic conditions, causes diseases including localized infections, fatal diseases, allergic responses, and inhaled conidia in humans. Herein, we present an overview of the most common diseases and allergic infections caused by Aspergillus species and their associated health hazards in various indoor environments worldwide.

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Evidence of endogenous volatile organic compounds as biomarkers of diseases in alveolar breath

Cited by 21 publications

References 46 publications

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Cryptococcus and Cryptococcosis in Cuba. A minireview

Aspergillus species in indoor environments and their possible occupational and public health hazards

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