Evidence of elevated colorectal cancer and adenoma rates for regional National Bowel Cancer Screening Program participants

Versace, Vincent L.; Forsyth, Anton D.; Vaughan, Rose; Morrice, Margaret G.; Morphett, Barry

doi:10.1111/ajr.12365

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…In Australia, those aged 50-54 years are consistently less likely to take part in the NBCSP, with current participation rates in this group sitting at 32% compared with the national average of 42% [2]. There is also evidence that those living in rural areas are more likely to have higher rates of bowel cancer and adenoma relative to national statistics [43]. With a third of Tasmania's population residing in rural and remote areas [44], raising awareness of bowel cancer screening in this population is even more imperative.…”

Section: Discussionmentioning

confidence: 99%

Public Awareness of Bowel Cancer Risk Factors, Symptoms and Screening in Tasmania, Australia: A Cross-Sectional Study

Lee

Versace

Obamiro

2022

IJERPH

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Tasmania has one of the highest bowel cancer incidence and death rates in the world. Public awareness of risk factors, symptoms, and early detection of bowel cancer is important for minimising the burden of disease. This study measured awareness levels of bowel cancer risk factors, symptoms and screening in Tasmania. An online survey of 3703 participants aged 18 years and older found that alcohol consumption, low physical activity levels, and having diabetes were the least known risk factors for bowel cancer. Over half of all participants were unaware the risk of bowel cancer increased with age, and 53 percent were not confident they would notice a bowel cancer symptom. Over a third of survey respondents did not know that screening commenced at the age of 50. The results indicate that a targeted campaign to increase bowel cancer awareness in Tasmania may help reduce the high rates of morbidity and mortality from the disease.

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Section: Discussionmentioning

confidence: 99%

Public Awareness of Bowel Cancer Risk Factors, Symptoms and Screening in Tasmania, Australia: A Cross-Sectional Study

Lee

Versace

Obamiro

2022

IJERPH

Self Cite

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“…4 Patients in regional areas have higher rates of CRCs and adenomas detected. 5 People in areas classified as 'very remote' 6 had a 26.5% participation rate in NBCSP screening, compared to 43.4% for 'major cities', and a diagnostic assessment rate after a positive iFOBT of 43%, vs 64% for major cities, as of the 2022 NBCSP monitoring report. 3 There are many barriers to screening that may explain these lower participation rates.…”

Section: Introductionmentioning

confidence: 99%

“…The program is effective at detecting blood in stool samples, an early sign of CRC, and is highly cost‐effective 4 . Patients in regional areas have higher rates of CRCs and adenomas detected 5 …”

Section: Introductionmentioning

confidence: 99%

The ‘hot zone policy’ for colorectal cancer screening presents unique risks and opportunities for rural Australia

Worthington

Lew

et al. 2023

Australian J Rural Health

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Objective Colorectal cancer has geographic inequities in Australia, with higher mortality rates and lower participation in the National Bowel Cancer Screening Program (NBCSP) in remote and rural areas. The at‐home kit is temperature‐sensitive, necessitating a ‘hot zone policy’ (HZP); kits are not sent when an area's average monthly temperature is above 30°C. Australians in HZP areas are susceptible to potential screening disruptions but may benefit from well‐timed interventions to improve participation. This study describes the demographics of HZP areas and estimates the impacts of potential screening changes. Methods The number of individuals in HZP areas was estimated, as well as correlations with remoteness, socio‐economic and Indigenous status. The potential impacts of screening changes were estimated. Results Over a million eligible Australians live in HZP areas, which are more likely to be remote/rural, have lower socio‐economic status and higher Indigenous populations. Predictive modelling estimates that any 3‐month screening disruption would increase CRC mortality rates up to 4.1 times more in HZP areas vs unaffected areas, while targeted intervention could decrease mortality rates 3.4 times more in HZP areas. Conclusion People living in affected areas would be negatively impacted by any NBCSP disruption, compounding existing inequities. However, well‐timed health promotion could have a stronger impact.

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“…The incidence of colorectal adenoma (CRA) increases with age after the age of 30 and is common in young and middle-aged individuals over the age of 40, including sporadic and familial cases ( 1 ). The incidence of CRA in individuals aged >60 is as high as 40%, and the annual rate of adenoma progression to colorectal cancer (CRC) is ~0.25% ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)

Lin

et al. 2023

Oncol Rep

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Colorectal adenoma (CRA) is a premalignant lesion of colorectal cancer. The current treatment is surgical resection, but CRA is prone to recurrence, and there is no safe and effective drug to prevent adenoma recurrence and canceration. Recent studies have shown that natural compounds in plants have favorable antitumor effects. According to preclinical studies, natural polyphenols can regulate different signal pathways and targets to play a role in the treatment of CRA, which is closely related to its inhibition of proliferation, induction of apoptosis, inhibition of inflammation and oxidative stress, and regulation of intestinal flora. Natural polyphenols are potential candidates for CRA therapy due to their remarkable efficacy and safety. In the present review, attention was paid to the experimental research progress of natural polyphenols extracted from numerous plants in the treatment of CRA in the last 10 years. The present review provided new guidance for the study of CRA, clarified the therapeutic role of polyphenols in CRA, and evaluated for the first time, to the best of our knowledge, the therapeutic potential of natural polyphenols to treat CRA by targeting multiple genes and signal pathways and epigenetic modification. Contents 1. Introduction 2. Current treatment and management of CRA 3. Classification of polyphenols and their transformation in the intestine 4. Molecular targets of polyphenol for CRA: Preclinical studies 5. Discussion 6. Conclusion and prospects

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Evidence of elevated colorectal cancer and adenoma rates for regional National Bowel Cancer Screening Program participants

Cited by 5 publications

References 4 publications

Public Awareness of Bowel Cancer Risk Factors, Symptoms and Screening in Tasmania, Australia: A Cross-Sectional Study

Public Awareness of Bowel Cancer Risk Factors, Symptoms and Screening in Tasmania, Australia: A Cross-Sectional Study

The ‘hot zone policy’ for colorectal cancer screening presents unique risks and opportunities for rural Australia

Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)

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