Evidence of chorda tympani dysfunction in patients with burning mouth syndrome

Eliav, Eli; Kamran, Batya; Schaham, Rachel; Czerninski, Rakefet; Gracely, Richard H.; Benoliel, Rafael

doi:10.14219/jada.archive.2007.0234

Cited by 139 publications

(104 citation statements)

References 41 publications

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“…A number of researchers have posited trigeminal small-fiber neuropathy as a cause of BMS (18,19). Because older individuals often complain of dysgeusia followed by BMS, dysfunction of the chorda tympani nerve may represent a cause of BMS (20,21). In the present study, the central nervous system disorders were associated with psychosocial disturbances and may strongly contribute to BMS in middle-aged patients.…”

Section: Discussionmentioning

confidence: 53%

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

et al. 2015

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Section: Discussionmentioning

confidence: 53%

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

et al. 2015

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“…In addition, all patients used several drugs to treat systemic chronic diseases, which impair the diagnosis of primary BMS. The observations in this study show that the current definition of BMS may need to be revised due to the great difficulty in classifying the patient in the strict clinical criteria stablished, also evidenced by other researchers 3,21,22 .…”

Section: Discussionmentioning

confidence: 60%

Clinical characteristics and therapeutic response in patients with Burning Mouth Syndrome: accompanying 2 years

Carvalho

Gallo

Sugaya

et al. 2017

Rev. odontol. UNESP

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ResumoIntrodução: A Síndrome de Ardência Bucal (SAB) é uma condição caracterizada pelo sintoma de ardência na mucosa oral na ausência de qualquer sinal clínico. Sua etiologia ainda é desconhecida e, até o momento, não dispõe de tratamento efetivo. Objetivo: Avaliar o perfil do paciente portador de SAB, as terapias instituídas e seus resultados em estudo retrospectivo. Material e método: Foram coletados os dados clínicos e terapêuticos dos prontuários de pacientes diagnosticados com SAB, no período de janeiro de 2013 a abril de 2015, no Ambulatório da Disciplina de Estomatologia Clínica da Faculdade de Odontologia da Universidade de São Paulo. Os critérios para o diagnóstico utilizados se basearam nos estabelecidos pela International Headache Society em 2013 e foram observadas as terapêuticas empregadas e seus resultados. Resultado: Doze pacientes foram diagnosticadas com SAB neste período, todas do sexo feminino, média de idade 61,18 anos, e a principal região acometida pelo sintoma de ardor foi o ápice de língua. O tempo de duração deste sintoma variou de 6 meses a 25 anos. As terapias utilizadas para o controle de sintomas da SAB foram capsaicina, clonazepan tópico, laserterapia e homeopatia. Dentre as terapias instituídas, a capsaicina apresentou efeito imediato na redução dos sintomas. Conclusão: O presente estudo demonstrou que os desafios que circundam a obtenção de um tratamento efetivo para a SAB são diversos e estão principalmente relacionados ao desconhecimento da etiopatogenia da doença. O perfil demográfico dos pacientes aqui estudados foi semelhante ao descrito na literatura disponível, entretanto, as variáveis representadas por sintomas secundários (história médica, níveis de ansiedade e depressão) podem constituir fatores modificadores da resposta terapêutica e da própria etiopatogenia da doença. Descritores: Síndrome da Ardência Bucal; tratamento; dor neuropática AbstractIntroduction: Burning Mouth Syndrome (BMS) is a condition characterized by burning symptom of the oral mucosa in the absence of clinical signs. Its etiology is still unknown and, and to date there is no effective treatment. Purpose: The aim of this study was to evaluate patients with BMS profile and the therapies results in a retrospective study. Material and method: Clinical and therapeutic data were collected from records of patients with BMS diagnosed between January 2013 to April 2015 at the Clinic of Stomatology Clinic, Faculdade de Odontologia of Universidade de São Paulo, according to the criteria established by the International Headache Society in 2013. The therapies used for BMS control were also evaluated. Result: Twelve patients were diagnosed with BMS at this period. All of them were women with a mean age of 61.18 years and the apex of the tongue was the most common affected site and the duration of the burning sensation ranged from 6 months to 25 years. Many therapies were prescribed for BMS control, such as topical capsaicin, topical clonazepan, low level laser therapy and homeopathy. Among the established therapie...

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“…The taste nervous system is thought to provide central inhibitory control over afferent fibers responsible for pain in both the glossopharyngeal and trigeminal nerves. This is supported by the findings that anesthesia of the chorda tympani causes increased pain evoked by capsaicin on the contralateral anterior tongue, topical administration of lidocaine to affected areas increases oral burning, in the same manner as in phantom limb pain, and hypofunction of the chorda tympani can lead to taste disturbance [77]. A relation has been established between the genetic predisposition of 'supertasters', with the ability to elicit a bitter taste sensation with 6-n-propyl-thiouracil, and intensification of pain.…”

Section: Burning Mouth Syndromementioning

confidence: 74%

Diagnosis and Management of Trigeminal Neuropathic Pains

Napeñas

Zakrzewska

2011

Pain Manage.

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Background -There is a lack of consistent classification systems and incomplete understanding of mechanisms of trigeminal neuropathic pains, with very few randomized controlled trials.Trigeminal neuralgia -Comprehensive history, examination, imaging studies (i.e., MRI), and measures of pain and quality of life are essential.Carbamazepine is a first-line drug, however, its side effects and drug interactions make it difficult to use in practice, while oxcarbazepine shows promise but requires more high-quality trials to show its efficacy.Ablative surgery results in trigeminal nerve injury and gives pain relief for 3-5 years, but is accompanied by sensory loss and dysesthesias.Microvascular decompression offers the longest pain-free period and is indicated for patients with proven neurovascular compression.Trigeminal neuropathic pain -Trigeminal neuropathic pain is probably due to trauma of the trigeminal nerve.Management recommendations are based on case series and guidelines for other neuropathic pain conditions, with tricyclic antidepressants and anticonvulsants (e.g., gabapentin and pregabalin) as first-line therapies.Burning mouth syndrome -Neuropathic, hormonal and psychological factors are suspected as contributing to its pathophysiology.Secondary causes (local and systemic) of burning mouth must be ruled out to obtain a definitive diagnosis.Clonazapam and selective serotonin reuptake inhibitors have been shown to be effective in limited randomized controlled trials, with anticonvulsants considered to be another option.Future perspective -Consistent classification systems, taxonomy and phenotyping of conditions are required.Increased knowledge on pathophysiology and mechanisms will determine the choice of targeted therapies for these conditions. Summary Points

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Evidence of chorda tympani dysfunction in patients with burning mouth syndrome

Cited by 139 publications

References 41 publications

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

Clinical characteristics and therapeutic response in patients with Burning Mouth Syndrome: accompanying 2 years

Diagnosis and Management of Trigeminal Neuropathic Pains

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