Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes)

Dauphin, Gwenae͏̈lle; Legay, Vincent; Sailleau, Corinne; Smondack, S.; Hammoumi, Saliha; Zientara, Stéphan

doi:10.1099/0022-1317-82-9-2199

Cited by 28 publications

(20 citation statements)

References 45 publications

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“…Additionality, in Japan [20] and France [21], were reported RNA-positive BDV infection also in healthy horses. Our report expanded the infiltration area of BDV circulation in the world.…”

Section: Discussionmentioning

confidence: 97%

First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico

Torres–Castro¹,

Noh-Pech²,

Gutiérrez-Ruiz³

et al. 2016

AiM

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Borna Disease Virus (BDV) causes a progressive non-suppurative meningoencephalitis that sometimes occurs in mortality; this disease has been reported for over two centuries ago in horses, sheep and cats in Central Europe and some regions of Asia. Currently, it is known that it causes neurological symptoms in various species of vertebrates including human beings. In Yucatan, Mexico, there is a single serological report about the circulation of BDV in schizophrenia patients; however, nothing is known about the circulation in animals. We obtained serum samples of 100 horses without apparent clinical signs caused by BDV infection, from various sites in the region. Antibodies against BDV were detected by electrochemiluminescence immunoassay (ECLIA) method with three recombinant proteins: BDV p24, BDV p40 and BDV p10 as antigens; obtaining a high seroprevalence of 44% (44/100). This study generates the first report of the probable activity of the BDV in healthy horses in Mexico and has expanded the infiltration area of BDV in the world. Nevertheless, several molecular investigations are required to detect BDV-RNA circulating and find sequences for clarification of the origin of BDV in Mexican horses.

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“…Additionality, in Japan [20] and France [21], were reported RNA-positive BDV infection also in healthy horses. Our report expanded the infiltration area of BDV circulation in the world.…”

Section: Discussionmentioning

confidence: 97%

First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico

Torres–Castro¹,

Noh-Pech²,

Gutiérrez-Ruiz³

et al. 2016

AiM

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“…Some of the animals tested showed nervous disorders. BDV-RNA was detected in three horse brains, one cow brain and six fox brains, and also in fourteen blood samples [16]. Among these 14 horse blood samples that were infected with BDV, four represented interesting cases from an epidemiological point of view.…”

Section: Bdv Infections In Francementioning

confidence: 93%

“…The first reports of Borna disease only concerned horses and sheep, but BDV infection has been found in other warm-blooded animal species, such as cattle [11,26], goats, rabbits [42], dogs [66], cats [2,39,47], and a wide variety of other species such as zoo animals: ostriches [40], deers, monkeys, alpacas, llamas [51,53], or wild animals such as lynx [17], foxes [16] and wild birds [4]. The experimental disease is possible for almost all of these species, including primates.…”

Section: Host Range and Geographic Distributionmentioning

confidence: 99%

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Borna disease: current knowledge and virus detection in France

Dauphin¹,

Legay

Pitel

et al. 2002

Vet. Res.

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-For over two centuries, Borna disease (BD) has been described as a sporadically occurring infectious meningoencephalomyelitis affecting horses and sheep in Central Europe. Over the last decade, the BD epidemiology has been discussed. Firstly, its geographical distribution seems larger than what was previously thought. Secondly, the disease can affect a large number of warm-blooded animal species, including humans. The aetiological agent is the Borna disease virus (BDV), an enveloped, nonsegmented negative-stranded RNA virus classified in the new virus family Bornaviridae (Mononegavirales order). It can induce severe clinical signs of encephalitis with striking behavioural disturbances and may cause death. BDV genome has recently been detected in France in the blood and brain of several animal species (horses, bovines, foxes). meningoencephalomyelitis / Borna disease virus / epidemiology / diagnosisRésumé -La maladie de Borna : connaissances actuelles et détection du virus en France. La maladie de Borna est connue depuis plus de deux siècles en Europe centrale comme une méningoencé-phalomyélite d'origine infectieuse affectant les chevaux et les moutons. Depuis ces dix dernières années, l'épidémiologie de la maladie a été révisée puisque la répartition géographique de la maladie de Borna s'avère plus large que rapportée jusqu'alors. En outre, elle peut affecter un grand nombre d'espèces animales à sang chaud, y compris l'homme. L'agent étiologique est le BDV (virus de la maladie de Borna), virus enveloppé, à ARN simple brin, non segmenté et de polarité négative, récem-ment classifié dans la nouvelle famille des Bornaviridae, (ordre des Mononegavirales). Le BDV peut induire des signes cliniques sévères d'encéphalite virale avec des troubles comportementaux importants et il peut entraîner la mort de l'animal. Récemment, le génome du BDV a été mis en évidence en France dans le sang et le cerveau de plusieurs espèces animales (chevaux, bovins, renards). méningoencéphalomyélite / virus de la maladie de Borna / épidémiologie / diagnostic 127

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“…But over the years, the use of new diagnostics methods discovered the presence of natural BDV infections in other regions, such as Australia, the United States of America Richt et al, 2000), China (Hagiwara et al, 2001), the United Kingdom (Reeves et al, 1998), Japan , Israel (Teplitski et al, 2003), other European countries (Italy, Poland, Czech Republic, France, Switzerland) (Galabru et al, 2000;Pisoni et al, 2007) and others. Natural BDV infection was detected not only in horses and sheep but also in other animal species: cats (Berg et al, 2001;Reeves et al, 1998), dogs (Weissenbock et al, 1998), cattle , birds (Berg et al, 2001), foxes (Dauphin et al, 2001), and ostriches (Weismann et al, 1994). Borna disease virus infection differs in its course according to the species; the most serious form of Borna disease is described in horses and sheep with severe neurologic symptoms and high mortality rates, in contrast to other species ).…”

Section: Epidemiology Of Borna Disease Virus Infectionmentioning

confidence: 99%

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Racková¹,

Janů²

2011

Psychiatric Disorders - Worldwide Advances

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Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes)

Abstract: Borna disease virus (BDV) is

Cited by 28 publications

References 45 publications

First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico

First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico

Borna disease: current knowledge and virus detection in France

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

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