Evidence of aberration of the natural cytotoxic cell activity in Fundulus heteroclitus (Pisces: Cyprinodontidae) from the Elizabeth River, Virginia

Innate cellular immune function of anterior kidney leucocytes in the gulf killifish,Fundulus grandis

“…Natural cytotoxic cell activity against YAC-1 lymphoma targets was restricted to the lighter band and K562 erythrocytoma targets were not susceptible to killing by F. grandis cells in our studies. These data di#er from those described in F. heteroclitus by Faisal et al (1991). In their studies, F. heteroclitus NCC cells were capable of lysing K562 targets at an activity level greater than the activity of F. grandis cells against YAC-1 targets described herein.…”

“…The immune system of F. heteroclitus has also been characterised to a limited degree (Hightower et al, 1984) and found to be sensitive to the presence of a variety of organic and inorganic xenobiotics (Gardner & Yevich, 1969;Faisal et al, 1991;Roszell & Anderson, 1996).…”

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

“…Immune function has been advocated as a sensitive biomarker of moderate ecological significance (Mathews et al 1990;Fournier et al 2000;Bols et al 2001). In agreement with this assertion, measures of cellular innate immune function including phagocytic cell activity (phagocytosis, bactericidal activity, reactive oxygen or nitrogen species production) and cytotoxic-cells have been successfully utilized as markers of immunomodulation by a number of investigators (Faisal et al 1991;Kelly-Reay and Weeks-Perkins 1994;Arkoosh et al 1996;Rice and Schlenk. 1995;Roszell and Anderson 1997;Clemons et al 1999;Carlson et al 2002;Ripley et al 2008).…”

“…Disruption of this cell population, therefore may have serious ramifications including reduced resistance to parasites and viruses and a lessened ability to remove neoplastic cells. PAH contamination has been reported to affect cytotoxic cell activity in environmental studies, and the effect is suppressive (Faisal et al 1991;Seeley and Weeks-Perkins 1997). Likewise, PCB exposure is known to affect this cell population (Regala et al 2001).…”

Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics

“…Basic parameters of immune function, from phagocytosis and respiratory burst to antibody production, have been evaluated as biomarkers of environmental stress. In general, exposure to pollutants and other stressors led to a decrease in immune function (Fries, 1986;Faisal et al, 1991;Fournier et al, 1998;Baier-Anderson et al, 2000;Rice and Xiang, 2000;Boleza et al, 2001). However, some differences in the results between in vivo and in vitro exposures suggest modulation of certain immune parameters in vivo (Roszell and Anderson, 1993;Roszell and Anderson, 1994;Roszell and Anderson, 1996), or differences in the responses to the complex mixtures of contaminants present in the field (Kelly-Reay and Weeks-Perkins, 1994).…”