Evidence of a rapid decrease in prevalence of Helicobacter pylori infection in children of a high risk group living in Germany

Rothenbacher, Dietrich; Schultze, Viola; Jähnig, Peter; Scharschmidt, Bruce F.; Brenner, Hermann

doi:10.1007/s00431-004-1427-8

Cited by 14 publications

(14 citation statements)

References 7 publications

(8 reference statements)

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“…Even in high prevalence population groups in developed countries, the infection is on the decline, particularly in childhood. In only one year, a group identified a 9% to 4% prevalence decrease in children of Turkish immigrants in Germany, in their first year of life (17) . In developing countries there is already increasing evidence of decrease in prevalence of infection and its consequences.…”

Section: Discussionmentioning

confidence: 99%

“…In developed countries, the past high prevalence of the infection was surpassed by improvement in environmental conditions, since its prevalence is closely related to socioeconomic factors. Some recent studies suggest that infection incidence in high-risk groups in developed countries, particularly immigrants, is declining, similarly to developing countries, as a consequence of better access to health, unintentional use of medications (antibiotics and antisecretory drugs) and improvement in environmental conditions (13,17,20) . In our country, documented improvement of infantile mortality and increase in life expectancy occurred in the last decades, attributed to improvement in basic sanitation and access to the public health system (10) .…”

Section: Introductionmentioning

confidence: 99%

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Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Kawakami

Machado

Ogata

et al. 2008

Arq. Gastroenterol.

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-Background -Decreasing prevalence of H pylori infection has been reported in some countries. Aim -To evaluate the prevalence of Helicobacter pylori infection in a 10-year period in children submitted to upper digestive endoscopy. Methods -It was a retrospective observational study. The records of 1,165 endoscopies performed during a 10-year period in a public hospital of the City of São Paulo, SP, Brazil, in patients up to 18-year-old. Only the first endoscopy was considered. Helicobacter pylori infection was defined by the rapid urease test, performed with one fragment of antral mucosa. Chi-square for trend has been estimated to compare Helicobacter pylori prevalence across the period. Results -The main indication for endoscopy was epigastric pain (47.4%). There were 392 patients with H pylori infection (33.6%), 12.8% being infants, 19.4% toddlers, 28.8% schoolchildren and 46.3% adolescents. Prevalence was 60.47% in the first year of the study and 30.43% in the last. Among the less than 6-year-old patients there was a decrease in infection prevalence from 25% for the 1993-6 period to 14.3% in the 2000-02 period, while among the over 12-year-old patients the decrease was from 55.5% in the first period to 39.6% in the latter. The decrease in H pylori infection prevalence was more intense within patients with epigastric pain, in which prevalence has decreased from 48.2% (92/191) in 1993-6, to 41.9% (65/155) in 1997-9 and 27.7% (57/206) in 2000-02. Conclusion -The study suggests a significant decrease in the prevalence of H pylori infection regarding the studied patients. The trend was mainly observed in the younger age group and in patients with epigastric pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Kawakami

Machado

Ogata

et al. 2008

Arq. Gastroenterol.

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“…Decrease in the prevalence of H.pylori infection was reported in European countries like Finland, Denmark, Germany among others previously 12,13 . A study from Finland showed a decrease in serum H. pylori IgG positivity from 56 to 31 percent in adults 5 .…”

Section: Discussionmentioning

confidence: 99%

Change of Helicobacter pylori prevalence in a decade among children undergoing endoscopy

Yaman¹,

Kuloğlu²,

Kahveci³

et al. 2016

Turk J Pediatr

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A total of 380 children, 131 in Group I and 249 in Goup II were recruited in the study. H. pylori postivity was found to be higher in Group I (% 48.1 and % 23.1, respectively, p < 0.001). Gastritis and atrophy were associated with H. pylori and both were more prevalent in Group I (p < 0.001). Our study demonstrates that H. pylori prevalence is decreasing in a pediatric population undergoing EGD in Ankara. This is the most recent study regarding pediatric H. pylori prevalence change in Turkey that we know of.

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“…Although infection rates are decreasing in pediatric populations from different regions, with prevalence ranging from less than 10% to 28% (16,17,18,21,27) , H. pylori still plays an important role in the pathogenesis of peptic ulcer disease, gastric adenocarcinoma and gastric mucosaassociated lymphoid tissue lymphoma (2) -diseases that carry high morbidity and mortality rates. H. pylori infection is acquired predominantly in childhood (18,31) .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Oliveira

Ferreira

Camerin³

et al. 2014

Arq. Gastroenterol.

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-Context -Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. Objective -Describe the prevalence of infection with cagA-positive H. pylori strains in a group of children and adolescents who underwent esophagogastroduodenoscopy in Porto Alegre, Rio Grande do Sul. Methods -Fifty-four gastric biopsy specimens of children and adolescents with H. pylori infection demonstrated by histology, urease test and molecular analysis were tested for the presence of cagA-positive H. pylori strains by the polymerase chain reaction method. Results -The prevalence of cagA-positive H. pylori was 29.6% (95% confidence interval, 18 to 43.6%). There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histological features of patients infected with cagA-positive strains as compared with those infected by cagA-negative strains. Conclusions -The study showed a low prevalence of infection with cagA-positive H. pylori strains among children and adolescents who underwent EGD in southern Brazil, in comparison to studies conducted with children from other regions of Brazil. There was no association between the presence of cagA-positive strains and more severe clinical presentations in the studied sample.

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Evidence of a rapid decrease in prevalence of Helicobacter pylori infection in children of a high risk group living in Germany

Cited by 14 publications

References 7 publications

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Change of Helicobacter pylori prevalence in a decade among children undergoing endoscopy

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

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