Change of Helicobacter pylori prevalence in a decade among children undergoing endoscopy

Yaman, Ali; Kuloğlu, Zarife; Kahveci, Ahmet; Sayıcı, Ufuk; Ensarı, Arzu; Kansu, Aydan

doi:10.24953/turkjped.2016.06.002

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…In the last decades, several socioeconomic changes, such as improved living standards and eradication therapy strategies, occurred in several Western countries, including Portugal. In this setting, we would expect a gradual decrease in the prevalence of this infection in Portugal, similarly to that observed in other developed and developing countries 30,38,39 . Recent H. pylori infection prevalence studies in Portuguese children and adolescents are scarce.…”

Section: Discussionsupporting

confidence: 75%

“…this setting, we would expect a gradual decrease in the prevalence of this infection in Portugal, similarly to that observed in other developed and developing countries. 30,38,39 Recent H. pylori infection prevalence studies in Portuguese chil- Martel and Parsonnet et al reported no significant gender difference between the infected and non-infected children. 22,30,33,[41][42][43] Contrarily, Ferrari's retrospective study, which includes patients with ages ranging from 9 to 96 years old, found higher infection prevalence in males in all age groups, including the group younger than 20 years.…”

Section: Discussionmentioning

confidence: 97%

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Time trend prevalence of helicobacter pylori infection and endoscopic findings in symptomatic children in Portugal: A retrospective study based on three time points in 2009, 2014, and 2019

et al. 2023

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Background: Helicobacter pylori infection acquisition occurs mainly in childhood and may be a critical factor in developing long-term complications. In contrast to other developed countries, previous studies have reported a relatively high H. pylori infection prevalence in Portugal, both in children and adults. However, there are no recent data concerning pediatric population. Materials and Methods:We performed a retrospective observational study concerning an 11 years period (2009, 2014, 2019), that included patients under 18 years old who underwent upper endoscopy at a pediatric tertiary center. Demographic, clinicalpathological, and microbiological data were collected. Results:Four hundred and sixty one children were included. The average age was 11.7 ± 4.4 years. In total, H. pylori infection was confirmed in 37.3% of cases (histology and/or culture) and a decreasing infection trend was observed (p = .027). The most common indication for endoscopy was abdominal pain, which was a good predictor of infection. Antral nodularity was present in 72.2% of the infected children (p < .001).In the oldest age groups, moderate/severe chronic inflammation, H. pylori density and lymphoid aggregates/follicles were positive predictors for the presence of antral nodularity. For all ages, the presence of antral nodularity, neutrophilic activity in the antrum and corpus and lymphoid follicles/aggregates in the antrum were positive predictors for the presence of H. pylori infection. Among the 139 strains tested for antibiotic susceptibility, 48.9% were susceptible to all tested antibiotics. Resistance to clarithromycin, metronidazole, and both was detected in 23.0%, 12.9%, and 6.5% of the strains, respectively; furthermore, resistance to ciprofloxacin and to amoxicillin was observed in 5.0% and 1.4% of the strains, respectively. Conclusions:The present study reports (for the first time in Portugal) a significant decreasing trend in the prevalence of pediatric H. pylori infection, although it remains relatively high compared to the recently reported prevalence in other South European countries. We confirmed a previously recognized positive association of How to cite this article:

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 97%

Time trend prevalence of helicobacter pylori infection and endoscopic findings in symptomatic children in Portugal: A retrospective study based on three time points in 2009, 2014, and 2019

et al. 2023

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“…However, in Yaman et al's(8) study, a decrease in the prevalence of Hp in children in our country was reported in the last two decades. In our study, NSAID (15.2%) was the highest risk factor in the Hp infection-negative group.…”

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confidence: 54%

Evaluation of Child Patients With Peptic Ulcer: A Single Center Experience

Hoşnut

Tekeli

2022

Kocatepe Tıp Dergisi

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OBJECTIVE: Data on the incidence of peptic ulcer in childhood and risk factors other than Helicobacter pylori (Hp) are insufficient. The aim of this study is to determine the frequency, clinical findings, risk factors and complications of gastroduodenal ulcer in children.MATERIAL AND METHODS: The endoscopy reports and file information of the children who underwent esophagogastroduodenoscopy in our center between May 2011 and December 2018 were reviewed retrospectively.RESULTS: Of the 5892 pediatric patients examined, 448 (7.6%) had peptic ulcers. Of the ulcers evaluated, 69% were duodenal, 27.4% were gastric, and 3.6% were both gastric and duodenal ulcers. The most common (52.2%) symptom was dyspepsia. The most common risk factor in peptic ulcers was Hp (66.5%). Nonsteroidal anti-inflammatory drugs were found to be the second most common (5.8%) risk factor. No risk factor could be demonstrated in 14.95% of the cases. Complications secondary to peptic ulcer disease were detected in 70 (15.7%) of the patients. The complications were; bleeding in 50 (12.7%) patients, gastric outlet obstruction in 11 (2.4%) patients, and perforation in 2 (0.4%) patients.CONCLUSIONS: Helicobacter pylori infection is the most important risk factor for peptic ulcer in children. However, in cases where Hp cannot be demonstrated, other risk factors should be investigated.

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“…In our country, there are similar studies showing the trend of HP in the same region over a period of time. 12 However, our study is valuable in terms of showing the continuous trend in a single center over a long period of time. Therefore, our study will contribute to the literature.…”

Section: Discussionmentioning

confidence: 99%

“… 25 In a study conducted in Ankara, while the prevalence of HP was 48.1% in 2002-2003, it was found to be 23.1% in 2012-2013 in the same center and was statistically significant ( P < .001). 12 In a meta-analysis published in 2022 and including 198 articles, the global prevalence of HP in children was 32.3%. In the same meta-analysis, the association of HP positivity with low economic status, having more children, sharing the same room, having no sewage system, having an infected family member, and drinking untreated water was statistically significant.…”

Section: Discussionmentioning

confidence: 99%