Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment

Chambrone, Leandro; Pannuti, Cláudio Mendes; Guglielmetti, Mariana Rocha; Chambrone, Luiz Armando

doi:10.1111/j.1600-051x.2011.01761.x

Cited by 91 publications

(110 citation statements)

References 51 publications

(199 reference statements)

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“…Our results corroborate Polyzos's and Chambrone's findings 30,31 . Two other systematic reviews were published in 2006 and 2007, but used case-control, cohort and controlled trials 34,35 .…”

Section: Comparisons With Other Studiessupporting

confidence: 92%

“…After examining eleven trials that included 6,558 patients, they found that periodontal treatment during pregnancy had no significant effect on the overall rate of preterm birth (OR = 1.15, 95%CI: 0.95-1.40; p = 0.15). In 2011, two meta-analyses were published by Chambrone et al 31 and Fogacci et al 32 , including 11 and 10 trials, respectively, neither of which supported the hypothesis that periodontal therapy reduces preterm birth and low birth weight indices.…”

Section: Comparisons With Other Studiesmentioning

confidence: 99%

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Periodontal disease treatment and risk of preterm birth: a systematic review and meta-analysis

et al. 2012

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The events leading to preterm birth are still not completely understood. A quantitative systematic review was performed to estimate the effects of periodontal care during pregnancy on preventing preterm birth and low birth weight. The meta-analysis included randomized trials with pregnant women with a diagnosis of periodontal disease before 20 weeks of gestation. Relative risk (RR) with 95% confidence intervals (95%CI) was calculated. We evaluated the reduction in preterm and low birth weight. Thirteen trials were included, comparing 3,576 women in intervention groups with 3,412 women receiving usual care. The meta-analysis of the effects of periodontal disease treatment during pregnancy indicated a non-significant reduction in preterm births (RR = 0.90; 95%CI: 0.68-1.19) and low birth weights (RR = 0.92; 95%CI: 0.71-1.20). The creation and examination of a funnel plot revealed clear evidence of publication bias. In summary, primary periodontal care during pregnancy cannot be considered an efficient way of reducing the incidence of preterm birth.

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Section: Comparisons With Other Studiessupporting

confidence: 92%

Section: Comparisons With Other Studiesmentioning

confidence: 99%

Periodontal disease treatment and risk of preterm birth: a systematic review and meta-analysis

et al. 2012

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“…20 Bacteria can enter the amniotic cavity and infect the fetus via several routes. The reported association Witkin between bacteria in the oral cavity and preterm birth 10 indicates that there is haematogenous dissemination of bacteria to the fetus. The detection of bacteria in the uterine cavity of healthy nonpregnant women implies that bacteria are present at this site before conception in some women.…”

Section: Bacteria-induced Preterm Birthmentioning

confidence: 99%

The vaginal microbiome, vaginal anti‐microbial defence mechanisms and the clinical challenge of reducing infection‐related preterm birth

Witkin

2014

BJOG

139

108

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Ascending bacterial infection is implicated in about 40-50% of preterm births. The human vaginal microbiota in most women is dominated by lactobacilli. In women whose vaginal microbiota is not lactobacilli-dominated anti-bacterial defence mechanisms are reduced. The enhanced proliferation of pathogenic bacteria plus degradation of the cervical barrier increase bacterial passage into the endometrium and amniotic cavity and trigger preterm myometrial contractions. Evaluation of protocols to detect the absence of lactobaciili dominance in pregnant women by self-measuring vaginal pH, coupled with measures to promote growth of lactobacilli are novel prevention strategies that may reduce the occurrence of preterm birth in low-resource areas.

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“…15 However, other studies and systematic reviews have revealed contradictory results. 16,44,[46][47][48][49][50] Vettore, Leal, Leao, da Silva, Lamarca, and Sheiham (2008) performed a case-control study among post-partum women (n= 542) to compare periodontal health status with birth outcomes. They concluded that periodontal disease did not increase the risk of preterm LBW according to 15 measures of periodontal disease .…”

Section: Necessity Of Future Researchmentioning

confidence: 99%

Adverse Pregnancy Outcomes and Maternal Periodontal Health

Kierce¹,

Co.²

2017

IJDOH

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Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment

Abstract: The results of this review show that MPDT did not decrease the risk of PB and/or LBW; however, the influence of specific aspects that were not investigated (disease diagnosis, extension and severity and the success of MPDT) should be evaluated by future RCTs.

Cited by 91 publications

References 51 publications

Periodontal disease treatment and risk of preterm birth: a systematic review and meta-analysis

Periodontal disease treatment and risk of preterm birth: a systematic review and meta-analysis

The vaginal microbiome, vaginal anti‐microbial defence mechanisms and the clinical challenge of reducing infection‐related preterm birth

Adverse Pregnancy Outcomes and Maternal Periodontal Health

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