Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries

Shetty, Omshree; Naresh, Kikkeri N.; Banavali, Shripad; Shet, Tanuja; Joshi, Rupali; Qureshi, Sajid; Mulherkar, Rita; Borges, Anita; Desai, Sangeeta

doi:10.1002/pbc.23346

Cited by 31 publications

(23 citation statements)

References 17 publications

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“…As Shetty et al . reported recently on a high incidence of human papillomavirus infections in non‐familial RB patients, we support the hypothesis that viral infections like HBV may play a role in the pathogenesis of MM particularly in patients with del (13q14).…”

Section: Discussionsupporting

confidence: 89%

Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma

Becker

Byl

Friedrich

et al. 2012

European J of Haematology

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Serological analyses within epidemiological cohort and case-control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations within 680 patients of the National Center for Tumor Diseases Heidelberg for which the serological HBV status (HBsAg and anti-HBc) and FISH data for five gains (1q21, 9q34, 11q23, 15q22, 19q13), five losses (6q21, 8p21, 13q14, 17p13, 22q11), and three IgH translocations [t(4,14), t(11,14), t(14,16)] were available. Deletion of 8p21 and 13q14 were shown associated with HBV positivity within hepatocellular carcinoma in other investigations. In the present evaluation, the odds ratio for loss of 8p21 was significantly elevated (OR = 2.74, 95% CL = 1.36-5.50, P = 0.0048) and for loss of 13q14 non-significantly increased (OR = 1.40, 95% CL = 0.74-2.65) in anti-HBc positive patients. The results provide further support for a role of HBV infection in the pathogenesis of MM.

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Section: Discussionsupporting

confidence: 89%

Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma

Becker

Byl

Friedrich

et al. 2012

European J of Haematology

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“…In addition, seven studies have tested for HPV DNA in retinoblastoma samples, most often among unilateral cases, and reported prevalences ranging from 5% (7 of 153 cases) to 82% (42 of 51 cases). Varying HPV types, not all considered high risk (HPV 16 or 18), were detected [10–16]. In contrast, a US study of retinoblastoma tumor samples (mostly unilateral) found all samples to be negative for 37 HPV types [56].…”

Section: Discussionmentioning

confidence: 99%

“…Increased risk was linked to older parental age [5–9], human papillomavirus (HPV) infection [5, 10–16], sunlight exposure [17, 18], diet [19], X-ray exposure [5], some paternal occupations [20–22], and in vitro fertilization [23–26]. However, the limited number of studies and the contradictory findings makes it difficult to draw conclusions regarding possible causality.…”

Section: Introductionmentioning

confidence: 99%

Perinatal characteristics and retinoblastoma

Heck

Lombardi

Meyers

et al. 2012

Cancer Causes Control

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Purpose The etiology of retinoblastoma remains poorly understood. In the present study, we examined associations between perinatal factors and retinoblastoma risk in California children. Methods We identified 609 retinoblastoma cases (420 unilateral, 187 bilateral, and 2 with laterality unknown) from California Cancer Registry records of diagnoses 1988–2007 among children <6 years of age. We randomly selected 209,051 controls from California birthrolls. The source of most study data was birth certificates. Multivariable logistic regression was used to examine associations between retinoblastoma and perinatal characteristics. Results Bilateral retinoblastoma was associated with greater paternal age [for fathers over 35, crude Odds Ratio (OR)=1.73, 95% Confidence Interval (CI) 1.20, 2.47] and with twin births (OR=1.93, 95% CI 0.99, 3.79). Among unilateral cases, we observed an increased risk among children of US-born Hispanic mothers (OR=1.34, 95% CI 1.01, 1.77) while a decreased risk was observed for infants born to mothers with less than 9 years of education (OR=0.70, 95% CI 0.49–1.00), a group that consisted primarily of mothers born in Mexico. We observed that maternal infection in pregnancy with any STD (OR=3.59, 95% CI 1.58, 8.15) was associated with bilateral retinoblastoma. Conclusions This study supports the findings of previous investigations reporting associations between parental age, HPV infection and retinoblastoma.

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“…The highest prevalence of HPV DNA in RBL was reported from the Asian Indian population. Fifty-three of 76 (65.7%) specimens tested positive for HPV DNA, especially high-risk HPV (HPV-16 / HPV-18) [6]. Another study conducted in Southern India revealed 48% positivity of HPV-DNA-all HPV-16-in 44 unilateral RBL cases [8].…”

Section: Discussionmentioning

confidence: 99%

“…Anand et al [5] demonstrated the presence of HPV in a subset of patients with RBL. Shetty et al [6] also suggested that infection of HPV-16/-18 may interfere with the cell regulatory process and lead to development of RBL in the Indian population. However, contradictory results were reported by Gillison et al [7] that revealed no relationship between HPV and RBL in North American populations.…”

mentioning

confidence: 99%

Human Papilloma Virus in Retinoblastoma Tissues from Korean Patients

Ryoo

Kim

Choung

et al. 2013

Korean J Ophthalmol

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PurposeRecent reports suggest the association of human papilloma virus (HPV) with retinoblastoma. This study was performed to elucidate whether HPV infection is related to retinoblastoma among Koreans.MethodsA total of 54 cases diagnosed with retinoblastoma were enrolled from Seoul National University Children's Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center. Presence of human papilloma viral DNA was detected by in situ hybridization in formalin-fixed paraffin-embedded retinoblastoma tissues using both probes against high- and low risk HPV types.ResultsThe mean age at diagnosis was 22.0 months (range, 1.1 to 98.0 months), and the mean age at enucleation was 27.8 months (range, 1.5 to 112.7 months) among the 54 patients with retinoblastoma. HPV was not detected in any of the retinoblastoma samples using either high risk or low risk HPV probes.ConclusionsOur study, being the first study in the Korean population, proposes that HPV infection may have no causal relationship with retinoblastoma in Koreans.

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Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries

Abstract: Our study lends support to the hypothesis that infection of HPV-16/-18 may play an important role in the development of nonfamilial form of RB in children in India.

Cited by 31 publications

References 17 publications

Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma

Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma

Perinatal characteristics and retinoblastoma

Human Papilloma Virus in Retinoblastoma Tissues from Korean Patients

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