Perinatal characteristics and retinoblastoma

Heck, Julia E.; Lombardi, Christina; Meyers, Travis J.; Cockburn, Myles; Wilhelm, Michelle; Ritz, Beate

doi:10.1007/s10552-012-0034-7

Cited by 65 publications

(60 citation statements)

References 58 publications

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“…As this was a record-based study, we did not seek informed consent from individual subjects. The demographic and gestational characteristics of cases and controls have been previously reported (Abrahao et al, 2015; Hall et al, 2016; Heck et al, 2012; Heck et al, 2013b; Heck et al, 2014, 2015; Heck et al, 2013c; Shrestha et al, 2013). …”

Section: Methodsmentioning

confidence: 99%

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Park

Ritz

Ling

et al. 2017

International Journal of Hygiene and Environmental Health

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Background The incidence of childhood cancers has been increasing, and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride). Methods We frequency matched by birth year approximately 20 cancer-free controls identified from birth records to all childhood cancers ages 0–5 in the California Cancer Registry diagnosed from 1988–2012; i.e. 13,636 cases and a total of 270,673 controls. Information on industrial releases of dichloromethane within 3km of birth addresses was retrieved from mandatory industry reports to the EPA’s Toxics Release Inventory (TRI). We derived exposure to dichloromethane within close vicinity of birth residences using several modeling techniques including unconditional logistic regression models with multiple buffer distances, inverse distance weighting, and quadratic decay models. Results We observed elevated risks for germ cell tumors [Odds Ratio (OR): 1.52, 95% Confidence Interval (CI) 1.11, 2.08], particularly teratomas (OR: 2.08, 95% CI 1.38–3.13), and possible increased risk for acute myeloid leukemias (AML) (OR: 1.29, 95% CI 0.93, 1.77). Risk estimates were similar in magnitude whether releases occurred in pregnancy or the child’s first year of life. Conclusion Our findings suggest that exposure to industrial dichloromethane releases may be a risk factor for childhood germ cell tumors, teratomas, and possibly AML.

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Section: Methodsmentioning

confidence: 99%

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Park

Ritz

Ling

et al. 2017

International Journal of Hygiene and Environmental Health

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“…Choice of potential confounders was guided by our prior work on retinoblastoma, 16 with all confounding factor information taken from birth certificates. We adjusted for maternal race/ethnicity and nativity (White non-Hispanic, Hispanic and US-born, Hispanic and foreign-born, other race/not specified), paternal age (<29, 30–34, 35+), and year of birth.…”

Section: Methodsmentioning

confidence: 99%

Retinoblastoma and ambient exposure to air toxics in the perinatal period

Heck

Park

Qiu

et al. 2013

J Expo Sci Environ Epidemiol

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We examined ambient exposure to specific air toxics in the perinatal period in relation to retinoblastoma development. Cases were ascertained from California Cancer Registry records of children diagnosed 1990–2007 and matched to California birth certificates. Controls were randomly selected from state birth records for the same time period. We chose 27 air toxics for the present study that had been listed as possible, probable, or established human carcinogens by the International Agency for Research on Cancer. Children (103 cases and 30,601 controls) included in the study lived within 5 miles (~8K) of an air pollution monitor. Using logistic regression analyses, we modeled the risk of retinoblastoma due to air toxics exposure, separately for exposures in pregnancy and the first year of life. With a per interquartile range increase in air toxics exposure, retinoblastoma risk was found to be increased with pregnancy exposure to benzene (OR=1.67, 95%CI 1.06, 2.64) and other toxics which primarily arise from gasoline and diesel combustion: toluene, 1,3 butadiene, ethyl benzene, ortho-xylene, and meta/para-xylene; these 6 toxics were highly correlated. Retinoblastoma risk was also increased with pregnancy exposure to chloroform (OR=1.35, 95%CI 1.07, 1.70), chromium (OR=1.29, 95%CI 1.04, 1.60), para-dichlorobenzene (OR=1.24, 95%CI 1.04, 1.49), nickel (OR=1.48, 95%CI 1.08, 2.01), and in the first year of life, acetaldehyde (OR=1.62, 95%CI 1.06, 2.48). Sources of these agents are discussed.

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“…In a large population based case-control study of childhood cancer in California we conducted previously, we found elevated odds for unilateral retinoblastoma among children of U.S.-born Hispanic women and decreased odds among children of mothers born in Mexico (8). We also observed elevated odds in infants born to mothers exposed to higher levels of traffic related air pollution during pregnancy (9–11).…”

Section: Introductionmentioning

confidence: 80%

Maternal diet during pregnancy and unilateral retinoblastoma

Lombardi

Ganguly

Bunin

et al. 2014

Cancer Causes Control

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Purpose Previous studies have suggested a role for parental diet in childhood cancer prevention, but there are few studies of retinoblastoma. The aim of this study was to examine the relation between maternal diet and unilateral retinoblastoma. Methods A case-control study of 163 unilateral RB cases and 136 controls ascertained information on maternal diet during pregnancy using a standardized food frequency questionnaire. Logistic regression was used to assess the relation between retinoblastoma and food groups and dietary patterns. Results We observed a negative association between retinoblastoma and intake of fruit [odds ratio (OR)=0.38, 95% confidence interval (CI) 0.14, 1.02]. Positive associations were seen with intake of cured meats (OR=5.07, 95%CI 1.63, 15.70) and fried foods (OR: 4.89, 95% CI: 1.72–13.89). A food pattern of high fruits and vegetables and low fried food and sweets was negatively associated with disease (OR=0.75, 95%CI 0.61, 0.92). Conclusion Our study provides preliminary evidence that mothers who consume diets higher in fruit and lower in fried foods and cured meats during pregnancy may reduce the risk of unilateral retinoblastoma in their offspring.

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Perinatal characteristics and retinoblastoma

Cited by 65 publications

References 58 publications

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California

Retinoblastoma and ambient exposure to air toxics in the perinatal period

Maternal diet during pregnancy and unilateral retinoblastoma

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