Evidence for the involvement of sulfidopeptide leukotrienes in the pathogenesis of pichinde virus infection in strain 13 guinea pigs

Liu, C.T.; Jahrling, Peter B.; Peters, C. J.

doi:10.1016/0262-1746(86)90121-6

Cited by 11 publications

(1 citation statement)

References 29 publications

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“…Guinea pigs are commonly used for modeling VHF disease, and coagulation values were reported in many of these studies [10,[32][33][34][35]. Strain 13/N guinea pigs are used frequently in arenavirus research [10,[36][37][38][39][40], but also to study other VHFs such as Ebola virus disease [41]. However, despite their frequent use in modeling, reference ranges for common clotting tests and indicators of clotting abnormalities in strain 13/N guinea pigs were not previously reported.…”

Section: Discussionmentioning

confidence: 99%

Prothrombin Time, Activated Partial Thromboplastin Time, and Fibrinogen Reference Intervals for Inbred Strain 13/N Guinea Pigs (Cavia porcellus) and Validation of Low Volume Sample Analysis

et al. 2020

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Inbred strain 13/N guinea pigs are used as small animal models for the study of hemorrhagic fever viruses. Coagulation abnormalities, including prolonged clotting times and bleeding, are characteristic of hemorrhagic fever in humans; patients often meet criteria for disseminated intravascular coagulation (DIC). Comprehensively evaluating coagulation function is critical in model development and studies of viral pathogenesis and therapeutic efficacy. Here, using the VetScan VSpro veterinary point-of-care platform, we developed reference intervals in both juvenile and adult strain 13/N guinea pigs for three coagulation parameters: prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen. In addition, for situations or species with limited availability of blood for clinical analysis, we investigated the validity of a modified collection approach for low-volume (0.1 mL) blood sample analysis of PT and aPTT.

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