“…High Low -- (Gemignani et al, 2004;Nikbahkt Dastjerdi, 2011;Ribeiro et al, 1997;Siddique et al, 2005) Identical Capability to transactivation Low High ---- Thomas et al, 1999) cell cycle arrest Low High ---- Pim and Banks, 2004) senescence induction Low High ---- Salvioli et al, 2005) DNA repair Low High High Low High Low (Siddique and Sabapathy, 2006;Wu et al, 2002) genomic stability maintenance Low High --High Low Qiu et al, 2008;Schwartz et al, 2011;Siddique and Sabapathy, 2006) apoptosis activation in extrinsic pathway Low High High Low High Low (Bendesky et al, 2007;Biros et al, 2002;Bonafe et al, 2002;Dumont et al, 2003;Pim and Banks, 2004;Schneider-Stock et al, 2004b;Siddique and Sabapathy, 2006;Wu et al, 2002) in intrinsic pathway High Low suppression of transformed cell growth High Low ---- (Thomas et al, 1999) survival in hypoxia High Low ---- (Sansone et al, 2007;Vannini et al, 2008) (Jeong et al, 2010) reproduction High Low ---- Jeong et al, 2010;Kang et al, 2009;Kay et al, 2006) Moreover, the C allele was found to be increased in women with recurrent implantation failure and individuals undergoing in vitro fertilization (IVF), and is a risk factor for implantation failure after IVF (Kang et al, 2009;Kay et al, 2006). Interestingly, the frequency of the G allele has been positively correlated with low winter temperatures (Shi et al, 2009).…”