p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

Effect of TP53 16-bp and β-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer

“…Genotyping of the 16-bp duplication polymorphism of the TP53 was done by PCR using forward and reverse primers as described previously (Guleria et al, 2012). PCR was performed using commercially available Prime Taq premix (Genetbio, South Korea) according to the manufacturer's recommended protocol.…”

Lack of Association of Intron 3 16 bp Polymorphism of TP53 with Breast Cancer among Iranian-Azeri Patients

“…Several polymorphisms have been identified in coding and noncoding regions of p53 that some of them have been associated with increased risk of cancer (Whibley et al, 2009). Three p53 well studied functional polymorphisms include Arg/Pro polymorphism in exon 4, 16 bp duplication in intron 3 (PIN3) and intron 6 G13964C alteration (Guleria et al, 2012), although two studies in India showed no link between polymorphisms and breast cancer (Roy et al, 2012;Vijayaraman et al, 2012) It has been reported that the 16 bp duplication in intron 3 is correlated with a reduced level of p53 mRNA and decreased both DNA repair capacity and apoptotic indices in lymmphoblastoid cell lines (Wu et al, 2013;Gemignani et al, 2004). Recently, several meta-analyses have highlighted the association between PIN3 and increased risk of cancer predisposition (Hu et al, 2010;He et al, 2011;Sagne et al, 2013;Wu et al, 2013).…”

TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients

“…In Asia, 84% of breast cancers are diagnosed from the age of 40 onwards (Ferlay et al, 2012). The interaction of p.R72P and PIN3 Ins16bp polymorphisms had been observed even in smaller sample size reported earlier (Guleria et al, 2012). In the current study, the role of p.R72P in breast cancer susceptibility was confirmed along with the PIN3 Ins16bp and r.13494g>a as it conferred increased risk.…”

“…In the present study higher frequency of A2A2 genotype was observed in the patients (7%) as compared to the controls (4%) but the results were not statistically significant. The A2A2 genotype has been reported to be associated with increased breast cancer risk in several studies (Weston et al, 1997;Wang-Gohrke et al, 2002, Costa et al, 2008Guleria et al, 2012). On the contrary, six fold increased risk for breast cancer in individuals with A1A1 genotype has been reported in Slovakian population (Franekova et al, 2007).…”