Evidence for Oral Excretion of E.B. Virus in Infectious Mononucleosis

Pereira, M. S.; Blake, JeanM.; Field, Anne M.; Rodgers, F G; Bailey, Laura; Davies, J G

doi:10.1016/s0140-6736(72)90229-2

Cited by 58 publications

(10 citation statements)

References 10 publications

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“…However these findings may be interpreted, some phenomenon is clearly concerned which is akin to that which occurs regularly in infectious mononucleosis. The demonstration by Henle et al (1968) and by Niederman, McCollum, Henle, and Henle (1968) that the clinical picture of infectious mononucleosis is very often associated with the development of antibodies to the EB virus, and the reports of the recovery of EB virus from these patients (Pereira, Field, Blake, Rodgers, Bailey, and Davies, 1972) allow us to investigate the significance of heterophile antibodies in asymptomatic individuals with a greater degree of precision.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic infection with EB virus

Sutton¹,

Marston²,

Almond³

et al. 1974

J Clin Pathol

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Positive Paul-Bunnell-Davidsohn reactions in sera from healthy individuals, usually blood donors (where the incidence may be 0-9 to 1 6%), have been described on several occasions (Barratt, 1941;Hobson, Lawson, and Wigfield, 1958;Virtanen, 1962). The significance of these observations is obscure and whether such heterophile antibodies represent subclinical infectious mononucleosis or are chance findings, to be dismissed as 'false-positive reactions', is not clear. The association of the EB virus with infectious mononucleosis (Henle, Henle, and Diehl, 1968;Evans, Niederman, and McCollum, 1968) sheds some light upon this problem, for the high incidence of antibodies to this virus in the community showed that asymptomatic infection with the probable causative agent of infectious mononucleosis was widespread. Holborow, Hemsted, and Mead (1973) have recently observed that a high proportion of patients with active infectious mononucleosis possessed antibodies to smooth muscle. Our own unpublished data support this observation but we were surprised that some of our control medical students and nurses also had smooth muscle antibodies. These antibodies are usually found in patients with some degree of liver damage (Johnson, Holborow, and Glynn, 1965) but our medical students and nurses were, apparently, quite healthy. Their sera were therefore tested for EB virus antibodies and, in the following report, we outline our findings and suggest that subclinical EB virus infection, associated with the development of smooth muscle antibodies, may be not uncommon in young adults.

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Section: Discussionmentioning

confidence: 99%

Asymptomatic infection with EB virus

Sutton¹,

Marston²,

Almond³

et al. 1974

J Clin Pathol

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“…Recent studies have demonstrated the presence of EBV-specific IgA serum antibodies in nasopharyngeal carcinoma (NPC) patients Ho et al, 1976). Oral excretion of EBV was first demonstrated in patients with infectious mononucleosis (IM) (Chang and Golden, 1971;Gerber et al, 1972;Pereira et al, 1972;Miller et al, 19736;Niederman et al, 1976). African children with Burkitt's lymphoma (BL) have the same incidence of oropharyngeal excretion of EBV (48%) as African controls (45%), while 77% of American IM patients secreted EBV, against only 13% of American controls (Gerber et al, 1976).…”

mentioning

confidence: 99%

Neutralizing EBV‐specific IgA in throat washings of nasopharyngeal carcinoma (NPC) patients

Des̀granges

de-Thé

et al. 1977

Intl Journal of Cancer

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Throat washings from 26 nasopharyngeal carcinoma (NPC) patients from Hong Kong and Tunisia were studied for the presence of transforming EBV. Only six (23%) were found positive which led to the hypothesis of a neutralizing factor in such salivas. The search for EBV-specific antibodies showed that NPC saliva contained neutralizing VCA and EA IgA (54 and 27% respectively) and VCA and EA IgG (73 AND 54% respectively). Both transforming and non-transforming throat washings contained virus particles as visualized by electron microscopy, but in non-transforming salivas (containing IgA and IgG) the particles were found to be clumped. Comparative study of throat washings from patients with Burkitt's lymphoma (BL); infectious mononucleosis (IM), immunodeficiencies, other cancers, and healthy subjects showed that IgA were restricted to NPC cases.

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“…In this Although the detection of heterophile antibodies, situation the detection of recent EB virus infection together with the observation of typical abnormal would be valuable. Unfortunately, neither the cells in the peripheral blood, are mainstays in the recovery of the virus in susceptible cells achieved by several groups of workers (Pereira et al, 1972;Gerber et al, 1972;Chang and Golden, 1971;Miller, Niederman, and Andrews, 1973) nor the detection of specific EB virus IgM antibody (indicating recent infection) described by Banatvala, Best, and Waller (1972) are procedures which can readily be applied on a large scale. The disparity which we have observed between the rates of development of EB complement fixing and virus capsid antigen antibodies (Sutton et al, 1971;Sutton et al, 1973) (Vahlquist et al, 1958).…”

Section: Methodsmentioning

confidence: 99%

“…Many infections with this virus must nevertheless be asymptomatic and, while antibodies appear to be acquired throughout childhood (Henle, Henle, and Diehl, 1968;Pereira, Blake, and Macrae, 1969), the peak incidence of clinical infectious mononucleosis is in early adult life (Hobson, Lawson, and Wigfield, 1958;Niederman, 1956;Newell, 1957). There has been speculation (Evans, 1960) that infectious mononucleosis might occur in unrecognized forms during childhood, and certainly the diagnosis of this condition in children of 5 years of age and under is often difficult (Carter and Penman, 1969).…”

mentioning

confidence: 99%