Evidence for Higher Red Blood Cell Mass in Persons With Unconjugated Hyperbilirubinemia and Gilbert’s Syndrome

Büyükaşık, Yahya; Akman, Ümit; Göker, Hakan; Haznedaroğlu, İbrahim C.; Shorbagi, Ali; Kilicarslan, Alparslan; Hasçelik, Gülşen; Büyükaşık, Naciye Şemnur

doi:10.1097/maj.0b013e318142be0d

Cited by 18 publications

(16 citation statements)

References 14 publications

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“…Despite the predominance of females in this group, no differences were found in these variables when the results were stratified by gender. Therefore, as previously reported [9,10], these results suggest that red cell mass and Hb concentration are associated with interindividual variations in bilirubin levels.…”

Section: Tablesupporting

confidence: 89%

Bilirubin Levels and Redox Status in a Young Healthy Population

et al. 2013

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Section: Tablesupporting

confidence: 89%

Bilirubin Levels and Redox Status in a Young Healthy Population

et al. 2013

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“…Actually, ESRD patients presenting higher bilirubin levels showed also high hemoglobin concentration and hematocrit and erythrocyte counts, suggesting that the red cell mass and hemoglobin concentration are associated with interindividual variations of bilirubin, as previously reported in a healthy population [30, 34] and in individuals with Gilbert's syndrome [35]. High bilirubin levels may be associated also with a decrease in the inflammatory status [36].…”

Section: Discussionsupporting

confidence: 61%

Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis

Faria

Kohlová

Ribeiro

et al. 2014

BioMed Research International

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We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed. The UGT1A1 genotype frequencies in HD patients were 49.2%, 42.4%, and 8.4% for 6/6, 6/7, and 7/7 genotypes, respectively. Although no difference was found in UGT1A1 genotype distribution between the three tertiles of bilirubin, significant differences were found with increasing bilirubin levels, namely, a decrease in platelet, leukocyte, and lymphocyte counts, transferrin, oxidized low-density lipoprotein (ox-LDL), ox-LDL/low-density lipoprotein cholesterol ratio, apolipoprotein (Apo) A, Apo B, and interleukin-6 serum levels and a significant increased concentration of hemoglobin, hematocrit, erythrocyte count, iron, transferrin saturation, Apo A/Apo B ratio, adiponectin, and paraoxonase 1 serum levels. After adjustment for age these results remained significant. Our data suggest that higher bilirubin levels are associated with beneficial effects in HD patients, by improving lipid profile and reducing the inflammatory grade, which might contribute to increase in iron availability. These results suggest a potential cardiovascular risk protection of bilirubin in HD patients.

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“…The condition is highly prevalent ranging from 3-12% of the population depending on the mode of diagnosis [1][2][3]. Intermittent jaundice is the only clinically recognised symptom, which can be triggered by infections, certain drugs and situations associated with low caloric intake such as gastrointestinal illness, surgery and fasting [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Gilbert's syndrome and the risk of death: A population‐based cohort study

Horsfall

Nazareth

Pereira

et al. 2013

J of Gastro and Hepatol

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Background and Aims Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age‐related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all‐cause mortality rates in those with and without Gilbert's syndrome. Methods Mortality rates in patients with a diagnosis of Gilbert's syndrome and raised bilirubin level (n = 4266) were compared with those of patients with similar characteristics but with normal bilirubin levels (n = 21 968). Multivariate Poisson regression was also used to estimate adjusted mortality rate ratios. Results During the 350 000 PYs of follow up across the Gilbert's and comparison cohorts, there were 1174 deaths. Mortality rates were 24/10 000 PYs in the Gilbert's cohort versus 50/10 000 PYs in the comparison cohort. Mortality rates were around half in patients with Gilbert's syndrome after accounting for sociodemographics and general health indicators (adjusted mortality rate ratio: 0.5 [95% confidence interval; 0.4–0.7; P < 0.001]). Conclusions Mortality rates observed for people with Gilbert's syndrome in the general population are almost half those of people without evidence of Gilbert's syndrome.

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Evidence for Higher Red Blood Cell Mass in Persons With Unconjugated Hyperbilirubinemia and Gilbert’s Syndrome

Cited by 18 publications

References 14 publications

Bilirubin Levels and Redox Status in a Young Healthy Population

Bilirubin Levels and Redox Status in a Young Healthy Population

Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis

Gilbert's syndrome and the risk of death: A population‐based cohort study

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