“…Because of the variable expression of KIEs, calculating paleotemperatures and interpreting the physical-chemical state of relic seep systems would yield ambiguous results dependent upon many assumptions regarding the magnitude of these offsets. Recent advances in clumped isotopes ( 30 ) have shown that with the analyses of multiple isotopologues at mass/charge ratio ( m / z ) = 47 (∆ 47 ) and m / z = 48 (∆ 48 ), the effects of these kinetic processes can be resolved ( 31 – 33 ), allowing for more confident reconstruction of temperatures ( 34 – 36 ), as well as identifying diagenetic effects ( 33 , 37 , 38 ), and fingerprinting the processes that caused the kinetic bias ( 26 , 27 , 32 , 35 , 38 , 39 ).…”