Evidence for dissociation of impairment on auditory discrimination and delayed response following lateral frontal lesions in monkeys

Gross, Charles G.; Weiskrantz, Lawrence

doi:10.1016/0014-4886(62)90057-2

Cited by 148 publications

(56 citation statements)

References 28 publications

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“…As first demonstrated by Blum (1952), an equally disabling deficit on delayed-response tasks can be produced by more focal lesions of just the "midlateral" portion of the PFC. In fact, small circumscribed lesions of just the principal sulcus (i.e., areas 46 and 9/46d) can produce deficits as great as larger total prefrontal lesions (Butters & Pandya, 1969;Butters, Pandya, Stein, & Rosen, 1972;Goldman & Rosvold, 1970;Goldman, Rosvold, Vest, & Galkin, 1971;Gross & Weiskrantz, 1962;Mishkin, 1957). Lesions of the periacuate (i.e., areas 8Ad and 8Av), superior frontal (i.e., areas 8B and 9), orbital (i.e., areas 11 and 12), premotor (i.e., areas 6, 8, and 44), inferior temporal, and parietal cortex do not typically cause significant or long-lasting impaired delayed-response performance (Butters & Pandya, 1969;Goldman & Rosvold, 1970;Goldman et al, 1971;Jacobsen, 1936; Rosenkilde, The delayed matching-to-sample task (middle) is a nonspatial working memory task and requires the monkey to remember an object over a delay.…”

Section: The Effects Of Prefrontal Lesions On the Performance Of Delamentioning

confidence: 99%

The effects of prefrontal lesions on working memory performance and theory

Curtis

D’Esposito

2004

Cognitive, Affective, & Behavioral Neuroscience

112

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Section: The Effects Of Prefrontal Lesions On the Performance Of Delamentioning

confidence: 99%

The effects of prefrontal lesions on working memory performance and theory

Curtis

D’Esposito

2004

Cognitive, Affective, & Behavioral Neuroscience

112

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“…For example, even though the prearcuate cortex lining the principal sulcus has been Abbreviation: HRP, horseradish peroxidase. considered essential for tasks based on delayed responses 4 ' 7 ' 19 ' 20 ' 25 ' 59 ' 79 -86 there is evidence that it is the middle third 9 ' 56 and the caudal part 85 of the banks of the principal sulcus which are crucial for the performance of these tasks. Consistent with these behavioral findings, it has been reported that neurons in the middle and caudal principalis regions fire in association with delayed response tasks.…”

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confidence: 99%

Cortical afferent input to the principals region of the rhesus monkey

1985

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Abstract-The sources of ipsilateral cortical afferent projections to regions along both banks of the principalis sulcus in the prefrontal cortex were studied with horseradish peroxidase in macaque monkeys. The principalis cortex receives a substantial proportion of its projections from neighboring prefrontal regions. However, differences were noted in the distribution of labeled cells projecting to the various principalis regions. These differences were most marked with respect to the relative proportion of cells originating in visual, auditory, somatosensory, premotor and limbic cortical areas. The findings indicate that the caudal ventral principalis region receives projections from both visual and visuomotor regions, whereas the anterior tip of the principalis appears to be the major target of projections from auditory association regions. The ventral bank at the middle extent of the principalis was the only case with a significant proportion of labeled cells in somatosensory association and premotor regions. There was a consistent increase in the proportion of labeled cells in limbic cortical areas projecting to more rostral principalis sites, irrespective of whether the injection was placed in the dorsal or ventral bank.These findings suggest that the caudal principalis region has a visual-visuomotor and the rostral, an auditorylimbic bias with respect to the long projections they receive.

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“…Specifically, the IFC is specialized for the processing of complex pictures, whereas the dorsolateral sector of the PFC is specialized for the analysis of the spatial location of objects in pictures. The inferior temporal (IT) cortex is involved in the integrity of identification, recognition and memory of complex pictures [4]. The IT projects to the IFC [31], which further strengthens the case for the functional dissociations between the IFC and dlPFC.…”

Section: Multiple Reference Frames In Prefrontal Attentionmentioning

confidence: 63%

“…Frontal lobectomy or, more impressively, the limited resection of the dlPFC of monkeys produces profound deficits in the delayed response (DR) task performance [1][2][3][4]. Jacobsen [5] was the first to show the deficits in the DR task performance resulting from dlPFC damage and interpreted these deficits to mean that the dlPFC damage impaired spatial memory (Figure 2).…”

Section: Deficits In Dr Tasks After Pfc Lesionsmentioning

confidence: 99%

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Prefrontal attention and multiple reference frames during working memory in primates

Yang

Wilson

et al. 2012

Chin. Sci. Bull.

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The prefrontal cortex (PFC) is responsible for executive functions, including planning, goal setting, problem solving, inhibitory control, monitoring, and action adjusting. Executive functions also include selective attention and the flexibility or switching of attention; therefore, attention is an executive function in which the PFC participates. Working memory (WM), which is the temporary maintenance and processing of particular information, is usually considered to be a basic neural mechanism underlying the executive functions. This review systematically discusses the relationship between the prefrontal WM and attention and emphasizes two forms of prefrontal attention. The first form occurs in the dlPFC, which encodes the location of objects with respect to the position of the head, thereby providing a frame of reference from which the focus of attention can be centered. The second occurs in the inferior convexity of the prefrontal cortex (IFC), which encodes the different attributes (shape, texture, color) of objects to enable the ability to focus on one or to switch attention between sensory attributes of objects. prefrontal cortex, attention, working memory, inferior convexity, multi-reference frames

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Evidence for dissociation of impairment on auditory discrimination and delayed response following lateral frontal lesions in monkeys

Cited by 148 publications

References 28 publications

The effects of prefrontal lesions on working memory performance and theory

The effects of prefrontal lesions on working memory performance and theory

Cortical afferent input to the principals region of the rhesus monkey

Prefrontal attention and multiple reference frames during working memory in primates

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