The effects of prefrontal lesions on working memory performance and theory

Curtis, Clayton E.; D’Esposito, Mark

doi:10.3758/cabn.4.4.528

Cited by 112 publications

(80 citation statements)

References 72 publications

(105 reference statements)

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“…This area is known to carry out a variety of cognitive functions including the top-down modulation of posterior brain regions (Miller, 2000;Miller and Cohen, 2001), maintenance of information in working memory (Levy and Goldman-Rakic, 2000;Curtis and D'Esposito, 2004), and manipulation of information in working memory (Petrides, 2000). Several studies have also shown that the activity of some parts of DLPFC is correlated with various measures of value during perceptual and economic decision-making tasks (Kim and Shadlen, 1999;Wallis and Miller, 2003;Seo et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making

Plaßmann¹,

O’Doherty²,

Rangel³

2010

J. Neurosci.

316

176

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An essential feature of choice is the assignment of goal values (GVs) to the different options under consideration at the time of decision making. This computation is done when choosing among appetitive and aversive items. Several groups have studied the location of GV computations for appetitive stimuli, but the problem of valuation in aversive contexts at the time of decision making has been ignored. Thus, although dissociations between appetitive and aversive components of value signals have been shown in other domains such as anticipatory and outcome values, it is not known whether appetitive and aversive GVs are computed in similar brain regions or in separate ones. We investigated this question using two different functional magnetic resonance imaging studies while human subjects placed real bids in an economic auction for the right to eat/avoid eating liked/disliked foods. We found that activity in a common area of the medial orbitofrontal cortex and the dorsolateral prefrontal cortex correlated with both appetitive and aversive GVs. These findings suggest that these regions might form part of a common network.

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Section: Discussionmentioning

confidence: 99%

Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making

Plaßmann¹,

O’Doherty²,

Rangel³

2010

J. Neurosci.

316

176

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“…Under these assumptions, lesions to the ventrolateral prefrontal cortex would be likely to detrimentally effect the learned association of high-level stimulus cues and their planned motor response. In fact, just such a selective deficit in visuo-motor association learning is observed from localized bilateral ventrolateral prefrontal cortical lesions (Bussey, Wise & Murray, 2001;Wang, Zhang & Li, 2000) as well as lesions that remove the connectivity between inferotemporal cortical centers in one hemisphere and ventrolateral prefrontal cortices in the other (Eacott & Gaffan, 1992;Parker & Gaffan, 1998; for a review: Curtis and D'Esposito, 2004).…”

Section: Motor Working Memorymentioning

confidence: 99%

“…Many laboratories have reported that prefrontal cells can retain their activation during a delay interval after their eliciting sensory stimuli terminate (e.g., Curtis & D'Esposito, 2004;Curtis, Rao & D'Esposito, 2003;D'Esposito & Postle, 1999;Funahashi, Bruce & Goldman-Rakic, 1989Funahashi, Inoue & Kubota, 1993Fuster, 1973;Fuster & Alexander, 1971;Fuster, Bauer & Jervey, 1985;Kubota & Niki, 1971;Mechelli, Price, Friston & Ishal, 2004;Miller, Erickson & Desimone, 1996;Niki, 1974;Ranganath & D'Esposito, 2005;Stern, Sherman, Kirchhoff & Hasselmo, 2001). This delay period activity, as such, has sometimes been called a form of "working memory".…”

Section: Introductionmentioning

confidence: 99%

“…In fact, lesion studies provide another compelling source of evidence for these functional localizations (for reviews: Curtis & D'Esposito, 2004;Goldman-Rakic, 1987;Passingham, 1993). Monkeys with dorsolateral prefrontal lesions show severe specific impairment in a wide range of tasks that require monkeys to retain spatial information in memory over a delay period (Goldman & Rosvold, 1970;Goldman, Rosvold, Vest & Galkin, 1971;Jacobsen, 1936;Levy & Goldman-Rakic, 1999;Mishkin, 1954;Mishkin & Pribram, 1954, 1955, 1956Mishkin, Vest, Waxler, & Rosvold, 1969;Petrides, 1991Petrides, , 1995Petrides, , 2000aPribram & Mishkin, 1956), particularly for stimuli presented in the contralateral visual field (Funahashi, Bruce & Goldman-Rakic, 1993).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Laminar cortical dynamics of cognitive and motor working memory, sequence learning and performance: Toward a unified theory of how the cerebral cortex works.

Grossberg¹,

Pearson²

2008

Psychological Review

124

183

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How do the layered circuits of prefrontal and motor cortex carry out working memory storage, sequence learning, and voluntary sequential item selection and performance? A neural model called LIST PARSE is presented to explain and quantitatively simulate cognitive data about both immediate serial recall and free recall, including bowing of the serial position performance curves, error-type distributions, temporal limitations upon recall, and list length effects. The model also qualitatively explains cognitive effects related to attentional modulation, temporal grouping, variable presentation rates, phonemic similarity, presentation of non-words, word frequency/item familiarity and list strength, distracters and modality effects. In addition, the model quantitatively simulates neurophysiological data from the macaque prefrontal cortex obtained during sequential sensory-motor imitation and planned performance. The article further develops a theory concerning how the cerebral cortex works by showing how variations of the laminar circuits that have previously clarified how the visual cortex sees can also support cognitive processing of sequentially organized behaviors. 2 INTRODUCTIONIntelligent behavior depends upon the capacity to think about, plan, execute, and evaluate sequences of events. Whether we learn to understand and speak a language, solve a mathematics problem, cook an elaborate meal, or merely dial a phone number, multiple events in a specific temporal order must somehow be kept in mind temporarily in working memory. Once events are stored temporarily in a working memory, they are then grouped, or chunked, through learning into unitized representations that encode whole sequences of events; e.g., word and action sequences. How these working memory sequences and unitized plans interact during cognitive information processing and motor performance remains one of the most important problems confronting cognitive scientists and neuroscientists.This article introduces the LIST PARSE (Laminar Integrated Storage of Temporal Patterns for Associative Retrieval, Sequencing and Execution) model, which proposes how the layered circuits of prefrontal and motor cortex may be organized to achieve processes of working memory storage, sequence learning, and motor planning and execution during both cognitive and sensory-motor tasks. A schematic of the model is shown in Figure 1. The model makes predictions about the laminar organization of such cortical circuits that go beyond present neurophysiological and anatomical knowledge. It formulates these predictions by integrating several sorts of convergent constraints: extensive behavioral and neuroimaging data about cognitive information processing in humans; behavioral and neurobiological data about sensorymotor storage and performance of familiar sequential actions in monkeys; anatomical data about the laminar circuits that are shared by granular neocortical areas and connectivity specific to the lateral prefrontal cortex; laminar models of visual cortex that can e...

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“…First, neurophysiological studies from non-human primates report similar WM delay-related activity in portions of the parietal and prefrontal lobes (Chafee & Goldman-Rakic, 1998;Gnadt & Andersen, 1988;Quintana & Fuster, 1999) and lesions to these areas lead to similar impairments of spatial WM (reviewed in Curtis & D'Esposito, 2004). Second, a large number of functional MRI studies report broad bilateral activations across much of the posterior parietal cortex (PPC) during visual WM tasks (reviewed in Wager & Smith, 2003).…”

Section: Introductionmentioning

confidence: 99%

The right parietal lobe is critical for visual working memory

Berryhill

Olson

2008

Neuropsychologia

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Neuroimaging evidence suggests that the parietal lobe has an important role in memory retrieval, yet neuropsychology is largely silent on this topic. Recently, we reported that unilateral parietal lobe damage impairs various forms of visual working memory when tested by old/new recognition. Here, we investigate whether parietal lobe working memory deficits are linked to problems at retrieval. We tested two patients with bilateral parietal lobe damage in a series of visual working memory tasks that probed recall and old/new recognition. Stimuli were presented sequentially and several stimulus categories were tested. The results of these experiments show that parietal lobe damage disproportionately impairs old/new recognition as compared to cued recall across stimulus categories. The observed performance dissociation suggests that the posterior parietal lobe plays a particularly vital role in working memory retrieval.

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The effects of prefrontal lesions on working memory performance and theory

Cited by 112 publications

References 72 publications

Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making

Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making

Laminar cortical dynamics of cognitive and motor working memory, sequence learning and performance: Toward a unified theory of how the cerebral cortex works.

The right parietal lobe is critical for visual working memory

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