Evidence for current diagnostic criteria of diabetes mellitus

Kumar, Ramesh; Nandhini, Lakshmana Perumal; Kamalanathan, Sadishkumar; Sahoo, Jayaprakash; Vivekanadan, M

doi:10.4239/wjd.v7.i17.396

Cited by 48 publications

(52 citation statements)

References 74 publications

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“…(9) Furthermore, a meta-analysis of 17 trials showed increased CAD, PAD and stroke frequency. (1,10,11) In our study, 10% of patients with pre-DM had macrovascular complications.…”

Section: Discussionsupporting

confidence: 45%

“…In patients with pre-DM, both impaired glucose tolerance and impaired fasting glucose are associated with a cardiovascular event. (1) Undiagnosed myocardial infarction is more prevalent in patients with pre-DM than in those with NGM (3.5% vs. 1.4%). (9) Furthermore, a meta-analysis of 17 trials showed increased CAD, PAD and stroke frequency.…”

Section: Discussionmentioning

confidence: 96%

“…(19) Individuals diagnosed with pre-DM have a higher incidence of nephropathy than those with NGM and the most common form of microvascular organ involvement among them is nephropathy. (1) The National Health and Nutrition Examination Survey's data analysis found that the prevalence of chronic renal disease was 11.8%, 17.1% and 24.2% in non-DM, pre-DM and newly diagnosed DM patients, respectively. (5) In our study, the prevalence of nephropathy in NGM, pre-DM and DM patients was 5%, 15.0% and 21.0%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Impaired fasting glucose and impaired glucose tolerance are two known prediabetic glucose metabolic disorders associated with microvascular and macrovascular complications. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) Epidemiologic studies have reported a 14% prevalence of pre-DM in populations over age of 45, (12,13) suggesting that the lifelong risk of developing DM in these individuals may be 48%-74%. (12,13) The prevalence of pre-DM and DM is estimated to be 592 million and 471 million people in 2035, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Renal cortical stiffness is markedly increased in pre-diabetes mellitus and associated with albuminuria

Sümbül¹,

Koç²,

Gulumsek³

2020

smedj

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Introduction:We aimed to investigate changes in renal cortical stiffness (CS) in Type II diabetes mellitus (DM) and pre-DM patients compared to subjects with normal glucose metabolism (NGM), as well as the usefulness of renal CS to determine the presence of nephropathy.Methods: This study included 125 individuals with NGM, pre-DM and Type II DM. Routine laboratory data was obtained, and micro-and macrovascular involvement were investigated.Urinary albumin-creatinine ratio (ACR) was measured for urinary albuminuria detection. In addition to routine renal ultrasonography, CS was measured using renal elastography. Results:Among the included patients, 42, 40 and 43 patients had NGM, pre-DM and Type II DM, respectively, with prevalence of nephropathy of 5%, 15% and 33%, respectively. Carotid and aortic intima-media thickness (IMT), renal width, and CS were found to be higher in the pre-DM and Type II DM groups than the NGM group. Aortic-IMT, renal width and urinary ACR levels were independently associated with CS. Patients with nephropathy were found to have a higher CS value than those without nephropathy (8.72 ± 1.67 kPa vs. 10.60 ± 1.74 kPa, p = 0.001). In ROC analysis, when the cutoff value for CS was taken as 9.2 kPa, renal CS predicted the possibility of nephropathy with 78.9% sensitivity and 71.4% specificity.Conclusion: CS values are significantly higher in patients with impaired glucose metabolism.We recommend CS measurement as part of routine screening of nephropathy in patients with pre-DM and newly diagnosed Type II DM.

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“…(9) Furthermore, a meta-analysis of 17 trials showed increased CAD, PAD and stroke frequency. (1,10,11) In our study, 10% of patients with pre-DM had macrovascular complications.…”

Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Renal cortical stiffness is markedly increased in pre-diabetes mellitus and associated with albuminuria

Sümbül¹,

Koç²,

Gulumsek³

2020

smedj

View full text Add to dashboard Cite

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“…The World Health Organisation (WHO) and 2017 American Diabetes Association (ADA) criteria 6 for disorders of glucose metabolism were used to determine the incidence of diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) after commencing combination antiretroviral therapy (ART) and antituberculosis therapy.…”

Section: Methodsmentioning

confidence: 99%

Incidence of Impaired Glucose Metabolism in Patients Started on Treatment for Hiv and PTB Co-Infection

P¹,

Gorantla²,

Rachakonda³

2017

jemds

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BACKGROUND A high proportion of HIV patients in India are having pulmonary tuberculosis. The combined therapy of both HIV + PTB causes many unwanted side effects. The following study mainly aimed to study the impaired glucose metabolism in those patients. The aim of the study is to determine the incidence of disorders of glucose metabolism in HIV-1 infected tuberculosis adult on antiretroviral therapy (ART) and antituberculosis therapy (ATT) admitted in tertiary health centre in Guntur, Andhra Pradesh, India. MATERIALS AND METHODSThis is two-year observational, analytical, prospective cohort study using data of all the HIV + PTB co-infected people admitted in tertiary health centre from March 2015 to March 2017. HIV infected ART naive tuberculosis patients eligible for ATT and ART (HIV-ART + ATT, n= 75) are included in the study. All participants had demographic, anthropometric, biochemical and radiological assessments at baseline; in addition, the HIV-ART group had follow-up assessments for 24 months on ART. Disorders of glucose metabolism namely diabetes mellitus (DM), impaired glucose tolerance and impaired fasting glucose were defined using WHO criteria at baseline 3, 6, 12, 18 and 24 months. Poisson approximations estimated incidence of disorders of glycaemia. Study Design-The study was a prospective, observational, analytical cohort study for two years among HIV and PTB co-infected patients. RESULTSAt baseline, the prevalence of DM was 0% in HIV-ART + ATT patients. During the follow-up using glucose-based WHO criteria, 5 patients developed DM during 150.2 person-years with an incidence rate of 3.3 cases per 100 PYFU (95%, CI 0.6 -5.1). 8 participants developed IGT during 156.1 PYFU with an incidence of 5.1 cases per 100 PYFU [95%, CI 3.5 -6.2]) and 5 participants developed IFG during 141.5 PYFU with an incidence of 3.5 cases per 100 PYFU [95%, CI 1.4 -4.6]). CONCLUSIONART was associated with increased incidence of impaired glucose metabolism. These findings underscore the importance of clinical monitoring of patients on ART and ATT.

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