Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity

Sonta, Toshiyo; Inoguchi, Toyoshi; Tsubouchi, Hirohito; Sekiguchi, Naotaka; Kobayashi, Kazuo; Matsumoto, Shingo; Utsumi, Hideo; Nawata, Hajime

doi:10.1016/j.freeradbiomed.2004.04.001

Cited by 160 publications

(120 citation statements)

References 47 publications

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“…4 On the other hand, obesity has been shown to increase oxidative stress. 24,25 In this study, 8-OHdG, a recognized oxidative stress marker, decreased significantly after 4 weeks. Although the decreases in body weight, serum creatinine and urinary protein did not correlate with the decrease in 8-OHdG, our results suggested that the decrease in oxidative stress might be one of the mechanisms by which weight loss improved renal function and proteinuria in obese subjects with diabetic nephropathy.…”

Section: Formula Diet For Diabetic Nephropathysupporting

confidence: 52%

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

et al. 2005

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OBJECTIVE:To evaluate the effect and safety of treatment with low-calorie formula diet on renal function and proteinuria in obese patients with diabetic nephropathy. DESIGN: Prospective study on safety and efficacy of a 4-week low-calorie (11-19 kcal/kg/day) normal-protein (0.9-1.2 g/kg/ day) diet partly supplemented with formula diet. SUBJECTS: In all, 22 obese patients with diabetic nephropathy (BMI: 30.475.3 kg/m 2 , HbA1c: 7.171.4%, serum creatinine: 172.4757.5 mmol/l, urinary protein: 3.372.6 g/day). RESULTS: The mean body weight decreased by 6.273.0 kg. The mean systolic blood pressure, creatinine, blood urea nitrogen, urinary protein, and 8-hydroxydeoxyguanosine decreased significantly by 7.5712.7 mmHg, 41.6723.9 mmol/l, 1.5071.61 mmol/l, 1.871.7 g/day, and 3.173.6 ng/mg creatinine, respectively. No patient had increased serum creatinine and urinary protein. Mean creatinine clearance (40.6717.9 to 46.1714.6 ml/s/1.73 m 2 ) and serum albumin showed no significant changes. Dserum creatinine and Durinary protein correlated with Dbody weight (r ¼ 0.62 and 0.49, respectively) and Dvisceral fat area (r ¼ 0.58 and 0.58, respectively), but did not correlate with Dsystolic blood pressure, Dfasting blood glucose and Dsubcutaneous fat area. CONCLUSION: These results suggested that weight reduction using formula diet might improve renal function and proteinuria safely for a short term in obese patients with diabetic nephropathy.

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Section: Formula Diet For Diabetic Nephropathysupporting

confidence: 52%

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

et al. 2005

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“…However, while mitochondrial-derived ROS are important for the initiation of oxidative stress responses in models of hyperglycemia, studies in other models indicate that activity of NADPH oxidase is required in order to sustain sufficient levels of ROS formation for the transduction of specific cellular responses (Kimura et al, 2005;Lee et al, 2006b;Schafer et al, 2003). Data showing increased activity of NAD(P)H oxidase in retinas and vascular tissues of diabetic patients and animals and in high glucose-treated endothelial cells suggest that NAD(P)H oxidase is an important source of ROS in the diabetic milieu (Al-Shabrawey et al, In Pressa; Al-Shabrawey et al, In Press-b; Al-Shabrawey et al, 2006;Ellis et al, 1998;Griendling et al, 2000;Inoguchi et al, 2003b;Sonta et al, 2004). Studies using a mouse model for ischemic retinopathy have revealed that superoxide production by NAD(P)H oxidase has a primary role in VEGF expression and retinal neovascularization (Al-Shabrawey et al, 2005).…”

Section: Oxidative Stress and Diabetic Retinopathymentioning

confidence: 99%

Vascular endothelial growth factor in eye disease

Penn

Madan

Caldwell

et al. 2008

Progress in Retinal and Eye Research

598

527

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Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the U.S., for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the principal causes of blindness in the infant, working age and elderly populations, respectively. Evidence suggests that vascular endothelial growth factor (VEGF), a 40 kDa dimeric glycoprotein, promotes angiogenesis in each of these conditions, making it a highly significant therapeutic target. However, VEGF is pleiotropic, affecting a broad spectrum of endothelial, neuronal and glial behaviors, and confounding the validity of anti-VEGF strategies, particularly under chronic disease conditions. In fact, among other functions VEGF can influence cell proliferation, cell migration, proteolysis, cell survival and vessel permeability in a wide variety of biological contexts. This article will describe the roles played by VEGF in the pathogenesis of retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. The potential disadvantages of inhibiting VEGF will be discussed, as will the rationales for targeting other VEGF-related modulators of angiogenesis.

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“…There is evidence of increased systemic oxidative stress in the ZDF rat (Chinen et al, 2007;Oltman et al, 2005;Oltman et al, 2006;Serkova et al, 2006;Sonta et al, 2004); however, an association between oxidative stress and the development of neuropathy is not yet established in the ZDF rat with IGT. We hypothesize that hyperglycemia induced ROS leads to injury of dorsal root ganglion (DRG) neurons.…”

Section: Introductionmentioning

confidence: 99%

Oxidative injury and neuropathy in diabetes and impaired glucose tolerance

Russell

Berent-Spillson

Vincent

et al. 2008

Neurobiology of Disease

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Clinical studies suggest that impaired glucose tolerance (IGT) is associated with the development of neuropathy. The aim of the current study was to determine if neuropathy developed in the female Zucker Diabetic Fatty (ZDF) rat, an animal model of IGT and type 2 diabetes. The ZDF rat develops impaired glucose tolerance (IGT) when fed a control diet, and frank diabetes when fed a high fat diet. Following 10 weeks of hyperglycemia, sensory nerve action potentials (SNAP) and compound motor action potentials (CMAP) were reduced and sensory conduction velocities were slowed (distal > proximal) in the tail and hind limb in ZDF animals with IGT and frank diabetes (p<0.01). Neuropathy was coupled with evidence of increased reactive oxygen species (ROS) and cellular injury in dorsal root ganglion (DRG) neurons from IGT animals. Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves.

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Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity

Cited by 160 publications

References 47 publications

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

Vascular endothelial growth factor in eye disease

Oxidative injury and neuropathy in diabetes and impaired glucose tolerance

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