Evidence for Bipolar Mood States

Lorr, Maurice; McNair, Douglas M.; Fisher, Seymour

doi:10.1207/s15327752jpa4604_16

Cited by 183 publications

(168 citation statements)

References 10 publications

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“…The VAMS happy scale scores did not decline after APTD, suggesting that, as with the VAMS depression scale scores, VAMS happy scale scores measure only large changes in mood. Alternatively, although there is evidence that the precise dimensions measured by the POMS are bipolar (Lorr et al 1982), the dimensions measured by the VAMS may not be bipolar.…”

Section: Discussionmentioning

confidence: 99%

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Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women

Leyton

2000

Neuropsychopharmacology

110

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Section: Discussionmentioning

confidence: 99%

“…At baseline, before ingesting the AA mixture, subjects completed the BDI, the bipolar Profile of Mood States (POMS; Lorr et al 1982;McNair et al 1988), and a visual analog mood scale (VAMS; Bond and Lader 1974). Five hours after ingestion of the mixture, the same scales were administered again.…”

Section: Methodsmentioning

confidence: 99%

Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women

Leyton

2000

Neuropsychopharmacology

110

112

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“…All female subjects except one participated while in the follicular phase of their menstrual cycle. Subjective effects of amino acid drinks were measured with the bipolar profile of mood states (POMS) (Lorr et al 1982) at the time of arrival at the laboratory, immediately before the fMRI scan, and after the fMRI scan.…”

mentioning

confidence: 99%

From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study

Nagano‐Saito

Cisek

Perna

et al. 2012

Journal of Neurophysiology

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Nagano-Saito A, Cisek P, Perna AS, Shirdel FZ, Benkelfat C, Leyton M, Dagher A. From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study. J Neurophysiol 108: 501-512, 2012. First published May 2, 2012; doi:10.1152/jn.00592.2011.-During simple sensorimotor decision making, neurons in the parietal cortex extract evidence from sensory information provided by visual areas until a decision is reached. Contextual information can bias parietal activity during the task and change the decision-making parameters. One type of contextual information is the availability of reward for correct decisions. We tested the hypothesis that the frontal lobes and basal ganglia use contextual information to bias decision making to maximize reward. Human volunteers underwent functional MRI while making decisions about the motion of dots on a computer monitor. On rewarded trials, subjects responded more slowly by increasing the threshold to decision. Rewarded trials were associated with activation in the ventral striatum and prefrontal cortex in the period preceding coherent dot motion, and the degree of activation predicted the increased decision threshold. Decreasing dopamine transmission, using a tyrosine-depleting amino acid mixture, abolished the reward-related corticostriatal activation and eliminated the correlation between striatal activity and decision threshold. These observations provide direct evidence that some reward-related functional MRI signals in the striatum are the result of dopamine neuron activity and demonstrate that mesolimbic dopamine transmission can influence perceptual and decision-making neural processes engaged to maximize reward harvest. basal ganglia; reward; motion discrimination; functional magnetic resonance imaging BRAINS MAKE PREDICTIONS about upcoming events to optimize behavioral choices (Llinas 2002). Prior information about likely outcomes can bias behavioral choice as can contextual information such as the likelihood of reward, allowing individuals to maximize the ratio of effort to reward. Reward anticipation can influence motivational states, decision making, and behavior. This transfer, from anticipation to action, is thought to involve the basal ganglia (Kawagoe et al. 1998;Lau and Glimcher 2008;Lauwereyns et al. 2002;Mogenson et al. 1980;Samejima et al. 2005;Satoh et al. 2003;Takikawa et al. 2002). Basal ganglia and frontal lobes form a corticostriatal system involved in both motor control and reward learning, making this network ideally suited to bias actions and decisions in favor of potentially rewarding outcomes. Dopamine plays a key role in this process, as dopamine released in the striatum by reward predicting cues appears to drive and promote the In recent models, it has been proposed that simple decisions involve an accumulation of neural activity building to a decision threshold (Bogacz and Gurney 2007;Carpenter and Williams 1995;Cisek 2007;Cisek et al. 2009;Lo and Wang 2006;Ratcliff 1978;Reddi et al. 2003;Shadlen et al. 1996;...

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“…It is an instrument particularly well suited to the present research because of its sensitivity to change in affective states. Six visual analogue scales (VAS) were derived from dimensional analysis of the 72-question, bipolar POMS questionnaire (Lorr et al 1982;McNair et al 1971;O'Connell et al 2012; O'Halloran et al 2004) (subsequently referred to as POMS-VAS). Using a VAS to evaluate current mood has been repeatedly demonstrated to be valid and reliable (e.g.…”

Section: Mood Assessmentmentioning

confidence: 99%

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

et al. 2017

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second-daily (n = 21). In a second experiment, we separately investigated the influence of reversed polarity upon these same measures, in response to acute stimulation (n = 23) and repeated stimulation (n = 11). We observed a systematic elevation of mood in both active conditions following single and repeated tDCS, the latter of which displayed a progressive elevation of mood from baseline. No mood change was noted in response to either single or repeated stimulation in the sham condition. Frontocerebellar tDCS stimulation advantageously influences mood in healthy participants, with an accumulative and potentiated effect following successive stimulations. The possibility that frontocerebellar stimulation may provide a novel therapeutic adjunctive or pre-emptive intervention in stress-related disorders and mood-related psychopathologies should be considered.

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Evidence for Bipolar Mood States

Cited by 183 publications

References 10 publications

Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women

Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women

From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

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