Evidence for autonomic nervous system dysfunction in females with idiopathic overactive bladder syndrome

Hubeaux, K.; Deffieux, X.; Raibaut, P.; Breton, F. Le; Jousse, M.; Amarenco, G.

doi:10.1002/nau.21154

Cited by 42 publications

(39 citation statements)

References 25 publications

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“…For instance, insulin resistance, the underlying mechanism of metabolic syndrome, and nicotine abuse may contribute to LUTS by sympathetic overactivity. Sympathetic overactivity is the main neuropathological finding in females with idiopathic OAB [25] and increased sympathetic activity of the bladder neck and prostate is also an independent aetiological factor for the development of LUTS in men [26].…”

Section: Discussionmentioning

confidence: 99%

Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Uzun¹,

Çiçek²,

Kocaman³

et al. 2013

Scandinavian Journal of Urology

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Section: Discussionmentioning

confidence: 99%

Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Uzun¹,

Çiçek²,

Kocaman³

et al. 2013

Scandinavian Journal of Urology

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“…Additionally, Hubeaux et al [12] reported that sympathetic overactivity is the main neuropathologic finding in patients with idiopathic OAB. Increased sympathetic activity of the bladder neck and prostate is also an independent etiologic factor for the development of LUTS in men [13].…”

Section: Discussionmentioning

confidence: 99%

Association of Insulin Resistance with Overactive Bladder in Female Patients

et al. 2012

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PurposeMetabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder (OAB). Additionally, insulin resistance is the underlying mechanism of metabolic syndrome. We aimed to investigate the association of insulin resistance with overactive bladder in female patients.MethodsWe prospectively conducted the study in our urology department. Female patients aged between 30 and 76 years old applied to our policlinics with or without OAB symptoms were enrolled. One hundred and twenty-two patients with OAB and 62 age-matched controls without OAB were included into the study. Fasting serum insulin, glucose, high-density lipoprotein (HDL-c), and triglycerides levels were measured. Insulin resistance value was obtained via the homeostasis model assessment of insulin resistance (HOMA-IR) calculator. The chi-square and Mann-Whitney U tests were used to compare differences in variables.ResultsSerum insulin level was found higher in female patients with OAB (11.5±6.2 µU/mL) relative to controls (6.4±2.1 µU/mL), statistically significant (P=0.036). In addition, HOMA-IR was significantly found higher in the OAB group, 2.86 (0.76 to 17.04) in comparison to controls, 1.32 (0.67 to 224), P=0.018. High-density lipoprotein cholesterol levels (HDL-c) were significantly found lower in females with OAB.ConclusionsInsulin resistance can be associated to overactive bladder and may play significant role in pathogenesis.

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“…Some components of LUTS have been linked to metabolic syndrome [5], and thus carry common risk factors for cardiovascular disease. LUTS might precipitate the development of cardiovascular events through multifactorial interlacing processes such as autonomic nervous dysfunction [6], [7], affective disorders [8], or adverse effects of medications for treating LUTS [9], [10]. However, the magnitude of the LUTS burden on the medical care for cardiovascular disease in a population scale remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Risk of Hospitalization for Acute Cardiovascular Events among Subjects with Lower Urinary Tract Symptoms: A Nationwide Population-Based Study

et al. 2013

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Background and PurposeLower urinary tract symptoms (LUTS) have been reported to be associated with metabolic syndrome and may predispose subjects to cardiovascular disease. The magnitude of the impact on the medical care remains to be elucidated. Based on a population-based claims dataset in Taiwan, we explored the association between LUTS and the risk of subsequent hospitalization for acute cardiovascular events.Materials and MethodsAmong a representative sample of one million subjects from nationwide health insurance enrollees, subjects with codes of LUTS in service claims and without previous cardiovascular diseases including stroke were compared with age- and sex-matched non-LUTS subjects in subsequent hospitalization for acute coronary syndrome or stroke from the recruited date (between 2001–2004) to 2009. The risk of outcomes was assessed with Kaplan-Meier curves and the impact of LUTS was estimated with Poison regression analysis and Cox proportional hazards models.ResultsWe included 4,553 LUTS subjects and 22,765 matched non-LUTS subjects, with a mean age of 47 years and 43% of men. Hypertension, diabetes, and hyperlipidemia were more prevalent in the LUTS group. The incidence rate of the composite endpoint was significantly higher in the LUTS group than in the non-LUTS group (5.4/1000 vs. 4.0/1000 person-years). The difference mainly derived from stroke rather than acute coronary syndrome. After adjusting for age, sex, diabetes, hypertension, and hyperlipidemia in multivariable analysis, LUTS remained a significant predictor (hazard ratio, 1.29; 95% confidence incidence, 1.06–1.50).ConclusionSubjects free of cardiovascular disease and presenting with LUTS are at risk of subsequent hospitalization for acute cardiovascular events, mainly stroke. The information might prompt practitioners encountering such patients to undergo appropriate diagnostic and preventive measures.

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Evidence for autonomic nervous system dysfunction in females with idiopathic overactive bladder syndrome

Abstract: These results suggest ANS dysfunction, predominantly a sympathetic ANS dysfunction, is associated with iOAB, specifically in patients with iOAB without DO.

Cited by 42 publications

References 25 publications

Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Association of Insulin Resistance with Overactive Bladder in Female Patients

Risk of Hospitalization for Acute Cardiovascular Events among Subjects with Lower Urinary Tract Symptoms: A Nationwide Population-Based Study

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