Association of Insulin Resistance with Overactive Bladder in Female Patients

Uzun, Hakkı; Yılmaz, Adnan; Kemik, Ahu Sarbay; Zorba, Orhan Ünal; Kalkan, Mehmet

doi:10.5213/inj.2012.16.4.181

Cited by 25 publications

(26 citation statements)

References 29 publications

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“…An overview of the selection process can be seen in Figure . Two studies were classified as case–control studies and the rest as surveys/cross‐sectional studies. The number of participants in studies ranged from 60 to 27,936.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies made a specific reference to OAB . The others categorised urinary symptoms in a variety of ways including LUTS, UUI, SUI and MUI.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, MetS has been implicated in the aetiology of LUTS and is thought to affect bladder function by its stimulating effects on the autonomic nervous system (ANS). Evidence of an association between MetS and OAB has been identified in women . MetS may cause OAB symptoms via a number of possible mechanisms.…”

Section: The Metabolic Syndrome and Lutsmentioning

confidence: 99%

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Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies

et al. 2014

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Objectives: To conduct a systematic review to determine whether there is an association between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) or overactive bladder (OAB) in women. Methods: We systematically reviewed English language observational studies on the effect of MetS (or component factors) on the presence of OAB or LUTS in women. We searched PubMed, Web of Science and The Cochrane Library with no date restrictions, checked reference lists and undertook citation searches in PubMed and Google Scholar. Studies were assessed for risk of bias. Because of heterogeneity, results were not pooled, but are reported narratively. Results: Of 27 included studies, only three looked at the link between MetS and OAB. The rest looked at links between OAB and components of MetS such as obesity or insulin resistance (n = 10), between MetS and urinary symptoms (n = 3) and between urinary symptoms and components of MetS, such as obesity (n = 14). Evidence is currently limited, but it does suggest that there may be important links between MetS and OAB and components of MetS such as obesity. Conclusions: The literature on MetS and OAB or LUTS in women is limited, and poor quality. However, the evidence available on obesity appears to support MetS as a contributor and predictor of LUTS in women. Many of the women with LUTS will be overweight and will have features of the MetS, if looked for. This provides not only an opportunity to encourage weight loss as an adjunct to therapy for the OAB symptoms but also a window of opportunity to address cardiovascular risk factors and prevent future cardiovascular morbidity and mortality. Review criteriaObservational studies examining the link between metabolic syndrome (MetS) (or components of MetS) and the presence of OAB or LUTS were identified through database and lateral searches. Message for the clinicBoth obesity and MetS have been shown to have complex links with LUTS. It is not known whether reducing insulin resistance and central obesity-related chronic inflammation and oxidative stress might prevent the onset of OAB or improve the outcome of current treatment. However, identifying women with MetS who harbour a portfolio of cardiovascular risk factors does provide an opportunity to address future cardiovascular risk, and prevent premature morbidity and mortality; although whether this will have an effect on the storage component of LUTS is unclear. The key variables to address are diet and lifestyle, especially exercise. The investigations should include a blood pressure recording, BMI and waist circumference measurement together with a lipid profile and HbA1c. These results should be transmitted to the GP for action.

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Section: Resultsmentioning

confidence: 99%

“…Fifteen studies made a specific reference to OAB . The others categorised urinary symptoms in a variety of ways including LUTS, UUI, SUI and MUI.…”

Section: Resultsmentioning

confidence: 99%

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Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies

et al. 2014

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“…Several studies have revealed a relationship between MetS and OAB [5,10,11] and their pathogeneses have many factors in common. For example, visceral obesity, aging, high body mass index, hypertension and increased HOMA-IR values have all been associated with both OAB and MetS [5,12]. Furthermore, MetS may contribute to sympathetic overactivity, causing detrusor overactivity and the activation of sensory neurons that secrete inflammatory mediators [13].…”

Section: Discussionmentioning

confidence: 99%

Association between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women with Overactive Bladder

Dağdeviren

Cengiz²

2017

Gynecol Obstet Invest

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Objective: This study aimed to determine the association between overactive bladder (OAB), metabolic syndrome (MetS) and serum nerve growth factors (NGF). Study Design: Serum samples from a group of 90 women that included patients with OAB (group 1), patients with both OAB and MetS (group 2) and healthy women without OAB and MetS (group 3). Each group included 30 patients. Serum levels of NGF were compared among the groups. Results: When the groups were compared with respect to NGF levels, group 2 was found to have significantly higher NGF levels (p = 0.001). A NGF threshold of >380 ng/mL had a sensitivity of 81.7% and a specificity of 100% to discriminate between groups 2 and 3. Conclusion: Our findings support the theory that possible sympathetic overactivity, proinflammatory status, oxidative stress and other pathological conditions associated with MetS and potentially involved in the development of OAB lead to increased serum NGF levels. These findings may help to shed light on the complicated pathogenesis of OAB.

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“…Women with obstetric history including complicated labour followed by continuous UI are suggestive of a istula. A detailed gynaecological history may help to understand the underlying cause, for example, polycystic ovarian disease and associated insulin resistance leading to UI among women of younger age group [7].…”

Section: History and Physical Examinationmentioning

confidence: 99%

Assessment of Urinary Incontinence (UI) in Adult Patients

Rizvi¹,

Ather²

2017

Synopsis in the Management of Urinary Incontinence

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The diagnosis and assessment of urinary incontinence (UI) are variable. In general, diagnosis is made in primary care using clinical evaluation (a good history and physical examination), bladder diary and validated symptom scales. Condition-speciic diagnosis is made in secondary care, and it often involves interventional tools such as urodynamic studies. The evidence available on the accuracy and acceptability of the assessment of UI is inconsistent and variable. A structured data collection tool was used for initial assessment of UI. Some key questions are required for initial assessment of UI in order to diagnose the type of UI. This chapter includes a gender-speciic evaluation based on history and clinical examination. Pelvic organ prolapse (POP) in female patients is associated with UI and POP diagnosis, and staging is made by clinical examination only, while male patients are examined for prostate obstructive urinary symptoms. Basic evaluation includes bladder diary in cases of overactive bladder and stress test, for stress urinary incontinence. Other diagnostic tests include urine analysis, urolowmetry and measurement of postvoid residual volume in cases of neurogenic bladder and benign prostate hypertrophy. Patients referred to specialist require further assessment of UI using urodynamic testing, electrophysiological test and imaging.

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Association of Insulin Resistance with Overactive Bladder in Female Patients

Cited by 25 publications

References 29 publications

Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies

Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies

Association between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women with Overactive Bladder

Assessment of Urinary Incontinence (UI) in Adult Patients

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