Evidence for an Association Between Chlamydia psittaci and Ocular Adnexal Lymphomas

Ferreri, Andrés J.M.; Giusti, Massimo; Ponzoni, Maurilio; Conciliis, Carlo de; Dell’Oro, Stefania; Fleischhauer, Katharina; Caggiari, Laura; Lettini, Antonia Anna; Cin, Elena Dal; Ieri, Rossella; Freschi, Massimo; Villa, Eugenio; Boiocchi, Mauro; Dolcetti, Riccardo

doi:10.1093/jnci/djh102

Cited by 503 publications

(383 citation statements)

References 30 publications

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“…Positive PCR products were purified and sequenced using an ABI 377 DNA sequencer (ABI PRISM Perkin Elmer) to confirm the specificity of PCR. In each case, three independent PCRs were carried out for each microbial species and only cases with positive PCR results in at least two of the three independent reactions were regarded as positive (Ferreri et al, 2004;Chanudet et al, 2006). Differences in the prevalence of infectious agents among various lymphoma subtypes and controls were analysed using Fisher's exact test ('stats Package' in R version 2.1.1).…”

Section: Methodsmentioning

confidence: 99%

“…Borrelia burgdorferi and Campylobacter jejuni are associated with cutaneous marginal zone B-cell lymphoma and immunoproliferative small intestinal disease, respectively (Cerroni et al, 1997;Lecuit et al, 2004). Recent studies show that Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions (Ferreri et al, 2004;Chanudet et al, 2006) and eradication of the organism results in complete regression of the lymphoma in some cases (Ferreri et al, 2005).…”

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confidence: 99%

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Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chanudet

Adam

et al. 2007

Br J Cancer

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Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (o20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma than non-LPD, although not reaching statistical significance. Mycoplasma pneumoniae DNA was not detected.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chanudet

Adam

et al. 2007

Br J Cancer

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“…The first to be reported has been the association of Helicobacter pylori with gastric disease, 6 followed by the linkeage of Borrelia burgdorferi with cutaneous tumors, 7 then almost simultaneously the association of Chlamydia psittaci with ocular adnexal MALT lymphoma and of Campylobacter jejuni with a extremely rare variant of MALT lymphoma known as immunoproliferative small intestinal disease (IPSID), respectively. 8,9 This acquired lymphoid tissue becomes genetically unstable with the acquisition of structural abnormalities such as t(1;14)(p22;q32), 10 t(11;18)(q21;q21), 11,12 and the most recently described t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and MALT1, 13 as well as numerical aberrations such as trisomy 3 and trisomy 18,14 leading to transformation into MALT lymphoma. The specific events responsible for the genetic aberration(s) remain to be discovered and, with the exception of the t(11;18)(q21;q21), which fuses the amino terminal of the API2 gene to the carboxyl terminal of the MALT1 gene generating a chimeric API2-MALT1 fusion transcript, 15 the true incidence of these genetic abnormalities is unknown.…”

Section: Introductionmentioning

confidence: 99%

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

et al. 2004

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Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18) (q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/ orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.

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“…[1][2][3][4][5][6] Lymphomagenesis is driven by multiple accumulated genetic abnormalities that determine the survival of neoplastic cells and involve mainly cell-cycle and apoptotic pathways. 7 MALT lymphomas in particular are a paradigm of alternative genetic events, involving different chromosomal aberration and/or apoptosis control protein expression, leading to the deregulation of apoptotic pathways through the activation of the NF-kB pathway.…”

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Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Franco

Camacho

Caleo³

et al. 2006

Modern Pathology

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Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IjBa, a marker of NF-jB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IjBa expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.

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Evidence for an Association Between Chlamydia psittaci and Ocular Adnexal Lymphomas

Cited by 503 publications

References 30 publications

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

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