Evidence for a Sex-linked Difference in Aspirin Metabolism

Menguy, René; Desbaillets, L.; Masters, Y. F.; Okabe, S

doi:10.1038/239102a0

Cited by 83 publications

(28 citation statements)

References 11 publications

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“…This is of interest in view of the hypothesis that there may be a sex-linked difference in aspirin metabolism (Menguy, Desbailliets, Masters & Okabe, 1972). The observations of Cummings & Martin (1964), that blood salicylate levels showed a good inverse relationship to body weight was made in healthy male subjects on a repeated dosage and they do not, therefore, contrast with the present findings.…”

Section: Discussioncontrasting

confidence: 56%

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

VOLANS

1974

Brit J Clinical Pharma

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The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non‐fasting states. Moderate activity resulted in no significant changes in absorption compared with that at rest. In non‐fasting subjects the absorption was reduced but this reduction was attenuated with time until after 60 min the plasma levels were similar. There was no interaction between the resting/non‐resting and fasting/non‐fasting absorption.

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Section: Discussioncontrasting

confidence: 56%

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

VOLANS

1974

Brit J Clinical Pharma

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“…A similar sex difference in aspirin hydrolysis was also shown in serum, i.e., a higher enzymatic activity in males than in females, and aspirin-esterase activity in rat liver homogenates has been reported to be lower in females than in males (1). However, these authors did not present any data nor did they provide a reference where these results could be found.…”

Section: Introductioncontrasting

confidence: 52%

“…Salicylic acid (SA), the product of aspirin hydrolysis, does not have the same pharmacological actions as aspirin (6)(7)(8)(9)(10)(11). Some investigators have proposed that the rate of aspirin hydrolysis has an important role in the pharmacological action and toxicity of salicylates (1,12,13).…”

Section: Introductionmentioning

confidence: 99%

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Gender differences in the activities of aspirin-esterases in rat tissues

Benedito

1998

Braz J Med Biol Res

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The activities of aspirin (acetylsalicylic acid)-esterases were measured in several tissues (liver, kidney, adrenal glands, brain and serum) from adult male and female Wistar rats. In males, both aspirin-esterase I (assayed at pH 5.5) and II (assayed at pH 7.4) activities were higher in liver homogenates when compared to females (aspirin-esterase I: males 48.9 ± 4.8 (N = 8) and females 29.3 ± 4.2 (N = 8) nmol of salicylic acid formed min -1 mg protein -1 ; aspirin-esterase II: males 41.4 ± 4.1 (N = 8) and females 26.1 ± 4.5 (N = 8) nmol of salicylic acid formed min -1 mg protein -1 , P<0.001). In serum, enzyme activity was higher in females than in males (aspirin-esterase I: males 0.85 ± 0.06 (N = 6) and females 1.18 ± 0.11 (N = 6) nmol of salicylic acid formed min -1 mg protein -1 ; aspirin-esterase II: males 1.03 ± 0.13 (N = 6) and females 1.34 ± 0.11 (N = 6) nmol of salicylic acid formed min -1 mg protein -1 , P<0.001). In the other tissues assayed, no statistically significant difference between males and females was found. There were no statistically significant differences when the enzymes were assayed in different phases of the estrous cycle in liver and serum. These results show that the differences in aspirin-esterase activity observed between males and females are not due to the estrous cycle. The gender difference obtained in our study may indicate an involvement of gonadal hormones in the control of the hydrolysis of aspirin. This possibility is currently under investigation.

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“…It is possible that salicylate derived from ASA differs in its disposition to that of administered salicylate, and that sex differences may emerge only after oral administration of aspirin. The higher ASA plasma concentrations in females are most likely due to an intrinsically lower concentration of aspirin esterase in female blood as suggested by Menguy et al (1972) and Windorfer et al (1974).…”

Section: Discussionmentioning

confidence: 99%

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

Ho¹,

Triggs²,

Bourne³

et al. 1985

Brit J Clinical Pharma

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The disposition of a low dose (600 mg) of acetylsalicylic acid (ASA) and its metabolites (salicylate, salicyluric acid and salicyl glucuronides) was studied in 25 male and female patients of different ages. Plasma levels of ASA and salicylate were found to be significantly higher in the females (young and elderly), whereas plasma levels of salicyluric acid were found to be significantly higher in the elderly (male and female) groups. The higher plasma levels of ASA and salicylate in the females appear to be due to an intrinsically lower metabolic activity in that sex, while the lower clearance of salicyluric acid leads to the accumulation of that compound in the aged. No age and sex effects were found to influence the volumes of distribution of ASA, salicylate and salicyluric acid.

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Evidence for a Sex-linked Difference in Aspirin Metabolism

Cited by 83 publications

References 11 publications

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

Gender differences in the activities of aspirin-esterases in rat tissues

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

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